Search Results - Drug Delivery

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2020-426 PRODRUGS OF PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN
Researchers at UCLA have developed prodrugs of peripherally-acting cannabinoid (PRCBs) receptor agonists for chronic pain relief. BACKGROUND: Cannabinoids are becoming prevalent in chronic pain treatments even though current marketed cannabinoid compounds may cause psychotropic effects or central nervous system (CNS)-mediated side effects. A potential...
Published: 12/10/2020   |   Inventor(s): Igor Spigelman, Alexander Spokoyny, Herbert Seltzman
Keywords(s): Cns, Drug Delivery, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > cns, Drug Delivery
2020-854 DUAL SELF-REGULATED DELIVERY OF INSULIN AND GLUCAGON BY A HYBRID PATCH
UCLA researchers have developed a novel hybrid microneedle patch that can deliver insulin and glucagon in a glucose-dependent manner. BACKGROUND: Type I diabetes (T1D) is an autoimmune disease in which pancreatic -cells are destroyed and there is a deficiency is insulin secretion. Type 2 diabetes (T2D) is a metabolic disorder resulting from insulin...
Published: 11/4/2020   |   Inventor(s): Zhen Gu
Keywords(s): Drug Delivery, Medical Devices and Materials, Metabolic Diseases, Other Polymers, Polymers, Therapeutics & Vaccines
Category(s): Drug Delivery, Drug Delivery > Other polymers, Therapeutics & Vaccines, Therapeutics & Vaccines > metabolic diseases, Medical Devices and Materials
2020-784 DEVELOPMENT OF A STING DELIVERING NANOPARTICLE FOR IMMUNOTHERAPY OF CANCER METASTASES TO THE LIVER
UCLA researchers in the Department of Nanomedicine have developed antigen presenting cells (APCs) targeting nanoparticles to deliver STING (stimulator of interferon genes) agonists to the liver for metastatic cancer treatment. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and estimated to become the second leading...
Published: 9/28/2020   |   Inventor(s): Andre Nel
Keywords(s): Drug Delivery, Immunotherapy, Nanoparticles, Oncology, Therapeutics & Vaccines
Category(s): Drug Delivery, Drug Delivery > Nanoparticles, Nanotechnology, Therapeutics & Vaccines, Therapeutics & Vaccines > immunotherapy, Therapeutics & Vaccines > oncology, Therapeutics & Vaccines > oncology immunotherapy
2019-954 Ultrastable Nanoemulsions in Disordered and Ordered States
SUMMARYResearchers in the Department of Chemistry and Biochemistry at UCLA have developed a method for the production of crystalline, iridescent emulsions stable to repeated dilutions.BACKGROUNDMany existing nanoemulsion formulations suffer from instability, especially with regards to dilution. To prevent the nano-droplets from coalescing, more and...
Published: 5/27/2020   |   Inventor(s):  
Keywords(s):  
Category(s): Chemical > Agricultural Chemicals, Chemical > catalysts/synthesis methods, Chemical > Fine Chemicals, Chemical > Reaction Technologies, Drug Delivery
Nanoemulsion Technologies
Mason Group Website: http://www.chem.ucla.edu/dept/Faculty/Mason/BACKGROUNDNanoemulsions are oil-in-water (or vice versa) suspensions of nanoscale droplets that range in size from 15 to 100 nm and have a variety of applications including drug delivery, agriculture, personal care and food products. Nanoemulsions have many advantages over traditional...
Published: 5/27/2020   |   Inventor(s): Thomas Mason
Keywords(s):  
Category(s): Chemical > catalysts/synthesis methods, Chemical > Reaction Technologies, Life Science Research Tools > microfluidics and mem's, Diagnostic Markers & Platforms > diagnostic platform technologies (e.g. microfluidics), Chemical > Fine Chemicals, Chemical > Instrumentation & Analysis, Drug Delivery > Nanoparticles, Separation technologies, Nanotechnology, other, bioproduction/bioconversion, Chemical > Agricultural Chemicals, Drug Delivery
2013-741 Bioengineered Thymic Aggregates for Implantation
Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...
Published: 2/26/2020   |   Inventor(s): Gay Crooks, Amelie Montel Hagen, Brile Chung
Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > autoimmune, Therapeutics & Vaccines > hematology, Therapeutics & Vaccines > immunotherapy, Drug Delivery, Drug Delivery > Other polymers
2015-612 PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS VIA RING OPENING REACTIONS
INTRO SENTENCE: UCLA researchers in the Department of Bioengineering have developed a simple approach to modify polypeptides and proteins.BACKGROUND: Functionalized polypeptides and proteins are useful as drug delivery vehicles, bioconjugates and novel ligands. However, synthesis of complex polypeptides with defined post-polymerization modifications...
Published: 9/10/2019   |   Inventor(s): Timothy Deming, Eric Gharakhanian
Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Drug Delivery, Peptide Base
Category(s): Chemical > Chemical Manufacturing & Industrial/Bulk Chemicals, Chemical > catalysts/synthesis methods, Drug Delivery, Drug Delivery > Peptide base
Silicon Nanovolcanos for Gene Delivery with High Efficiency and Cell Viability
INTRO SENTENCE: UCLA researchers in the department of Chemistry and Biochemistry have developed a novel technique of intracellular cargo delivery using nanovolcanos with high efficiency and cell viability.BACKGROUND: Intracellular cargo delivery facilitates cellular reprogramming and development of next generation gene and cellular therapies....
Published: 9/10/2019   |   Inventor(s): Paul Weiss, Hsian-Rong Tseng, Qing Yang, Xiaobin Xu, Shuang Hou, Steven Jonas
Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Drug Delivery, Gene Therapy, Other Polymers
Category(s): Chemical > Chemical Manufacturing & Industrial/Bulk Chemicals, Materials > surface engineering, Drug Delivery, Therapeutics & Vaccines > gene therapy, Drug Delivery > Other polymers
2017-846 NANOPARTICLES AND IMAGING METHODS FOR MRI-GUIDED STIMULI-RESPONSIVE THERANOSTICS
Case No. 2017-846SUMMARYUCLA researchers from the Department of Medicine have developed novel nanoparticle and imaging methods for the MRI-guided targeted delivery of therapeutic agents.BACKGROUNDMagnetic Resonance Imaging (MRI) is a widely used diagnostic imaging platform for both anatomical and functional imaging. MRI is increasingly being used in...
Published: 9/6/2019   |   Inventor(s): Jeffrey Zink, Holden Wu, Bastian Ruehle, Tess Armstrong
Keywords(s): Drug Delivery, Medical Imaging, MRI, Nanoparticles
Category(s): Drug Delivery, Drug Delivery > Nanoparticles, Medical Imaging, Medical Imaging > MRI
2017-086 MASSIVELY PARALLEL HIGH THROUGHPUT SINGLE CELL ELECTROPORATION (MSEP)
Massively Parallel High Throughput Single Cell Electroporation (MSEP)Tech ID: 30166 / UC Case 2017-086-0SUMMARYUCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel massively parallel, single cell electroporation platform (MSEP) that is high throughput, efficient, and maintains cell viability.BACKGROUNDElectroporation...
Published: 9/6/2019   |   Inventor(s): Pei Yu Chiou, Michael Teitell, Tuhin Subhra Santra
Keywords(s): Drug Delivery, Electronics & Semiconductors, Gene Therapy, Life Science Research Tools, Microfluidics And Mem's, Nanoparticles, Nucleic Acids
Category(s): Drug Delivery, Electrical > Electronics & Semiconductors, Life Science Research Tools, Therapeutics & Vaccines > gene therapy, Drug Delivery > Nanoparticles, Drug Delivery > Nucleic acids, Life Science Research Tools > microfluidics and mem's, fabrication technologies
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