Search Results - Drug Delivery

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2015-612 PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS VIA RING OPENING REACTIONS
INTRO SENTENCE: UCLA researchers in the Department of Bioengineering have developed a simple approach to modify polypeptides and proteins.BACKGROUND: Functionalized polypeptides and proteins are useful as drug delivery vehicles, bioconjugates and novel ligands. However, synthesis of complex polypeptides with defined post-polymerization modification...
Published: 9/10/2019   |   Inventor(s): Timothy Deming, Eric Gharakhanian
Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Drug Delivery, Peptide Base
Category(s): Chemical > Chemical Manufacturing & Industrial/Bulk Chemicals, Chemical > catalysts/synthesis methods, Drug Delivery, Drug Delivery > Peptide base
Silicon Nanovolcanos for Gene Delivery with High Efficiency and Cell Viability
INTRO SENTENCE: UCLA researchers in the department of Chemistry and Biochemistry have developed a novel technique of intracellular cargo delivery using nanovolcanos with high efficiency and cell viability.BACKGROUND: Intracellular cargo delivery facilitates cellular reprogramming and development of next generation gene and cellular therapies....
Published: 9/10/2019   |   Inventor(s): Paul Weiss, Hsian-Rong Tseng, Qing Yang, Xiaobin Xu, Shuang Hou, Steven Jonas
Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Drug Delivery, Gene Therapy, Other Polymers
Category(s): Chemical > Chemical Manufacturing & Industrial/Bulk Chemicals, Materials > surface engineering, Drug Delivery, Therapeutics & Vaccines > gene therapy, Drug Delivery > Other polymers
2017-846 NANOPARTICLES AND IMAGING METHODS FOR MRI-GUIDED STIMULI-RESPONSIVE THERANOSTICS
Case No. 2017-846SUMMARYUCLA researchers from the Department of Medicine have developed novel nanoparticle and imaging methods for the MRI-guided targeted delivery of therapeutic agents.BACKGROUNDMagnetic Resonance Imaging (MRI) is a widely used diagnostic imaging platform for both anatomical and functional imaging. MRI is increasingly being used i...
Published: 9/6/2019   |   Inventor(s): Jeffrey Zink, Holden Wu, Bastian Ruehle, Tess Armstrong
Keywords(s): Drug Delivery, Medical Imaging, MRI, Nanoparticles
Category(s): Drug Delivery, Drug Delivery > Nanoparticles, Medical Imaging, Medical Imaging > MRI
2017-086 MASSIVELY PARALLEL HIGH THROUGHPUT SINGLE CELL ELECTROPORATION (MSEP)
Massively Parallel High Throughput Single Cell Electroporation (MSEP)Tech ID: 30166 / UC Case 2017-086-0SUMMARYUCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel massively parallel, single cell electroporation platform (MSEP) that is high throughput, efficient, and maintains cell viability.BACKGROUNDEl...
Published: 9/6/2019   |   Inventor(s): Pei Yu Chiou, Michael Teitell, Tuhin Subhra Santra
Keywords(s): Drug Delivery, Electronics & Semiconductors, Gene Therapy, Life Science Research Tools, Microfluidics And Mem's, Nanoparticles, Nucleic Acids
Category(s): Drug Delivery, Electrical > Electronics & Semiconductors, Life Science Research Tools, Therapeutics & Vaccines > gene therapy, Drug Delivery > Nanoparticles, Drug Delivery > Nucleic acids, Life Science Research Tools > microfluidics and mem's, fabrication technologies
2016-579 PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES
Preparation Of Functional Homocysteine Residues In Polypeptides And PeptidesSUMMARYUCLA researchers in the Department of Bioengineering and Department of Chemistry & Biochemistry have developed a novel method for efficient, chemoselective transformation of methionines in peptides and polypeptides into stable, functional homocysteine derivatives...
Published: 9/6/2019   |   Inventor(s): Timothy Deming, Eric Gharakhanian
Keywords(s):  
Category(s): Drug Delivery, Drug Delivery > Peptide base
2016-521 METHODS COMPRISING IMMUNE SYSTEM MODULATION WITH MICROPOROUS ANNEALED PARTICLE GELS
Case No. 2016-521SUMMARYUCLA researchers have developed a novel microporous annealed particle (MAP) scaffold that acts as both a tissue growth scaffold and an immune modulatory system. The technology permits continuous, time-encoded, modulation of the immune system delivered injection/implantation of fabricated scaffold, comprised of the MAP gel te...
Published: 9/6/2019   |   Inventor(s): Tatiana Segura, Dino Di Carlo, Westbrook Weaver, Philip Scumpia, Jaekyung Koh, Donald Griffin
Keywords(s): Drug Delivery, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), Oncology Immunotherapy, Therapeutics & Vaccines, Vaccines
Category(s): Drug Delivery, Therapeutics & Vaccines > immunotherapy, Therapeutics & Vaccines > vaccines, oncology, Therapeutics & Vaccines > oncology immunotherapy, oncology > oncology (small molecules, peptides and antibodies), Therapeutics & Vaccines
2015-826 SATELLITE/HELPER VIRUS-LIKE SYSTEMS FOR AMPLIFYING RNA
Case No. 2015-826SUMMARYUCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for high protein expression levels, in situ, involving RNA-based therapeutics.BACKGROUNDThe RNA therapeutics industry is growing at a CAGR of 12% and is expected to reach $1.2 billion by 2020. These are a novel class of therapeutic...
Published: 9/6/2019   |   Inventor(s): William Gelbart, Charles Knobler, Devin Brandt, Adam Biddlecome, Richard Sportsman, Rees Garmann
Keywords(s): Drug Delivery, Life Science Research Tools, Nucleic Acid Platform Systems, Therapeutics & Vaccines
Category(s): Drug Delivery, Life Science Research Tools, Drug Delivery > nucleic acid platform systems, Therapeutics & Vaccines
2014-554 TREHALOSE HYDROGELS FOR STABILIZATION AND DELIVERY OF PROTEINS
Trehalose Hydrogels For Stabilization And Delivery Of ProteinsCase No. 2014-554-0SUMMARYUCLA researchers in the Department of Chemistry and Biochemistry have developed a novel trehalose hydrogel to help stabilize proteins for drug delivery.BACKGROUNDProteins are at the core of biologic drugs and are used to treat a range of disease states including...
Published: 9/6/2019   |   Inventor(s): Heather Maynard
Keywords(s): Drug Delivery, Medical Devices and Materials, Other Polymers, Therapeutics & Vaccines
Category(s): Drug Delivery, Medical Devices and Materials, Therapeutics & Vaccines, Drug Delivery > Other polymers
2014-317 ACTIVATING HIV LATENCY USING DRUG ENCAPSULATED NANOPARTICLES
Case No. 2014-317SUMMARYUCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have devised a novel method to target the HIV virus in patients using nanoparticles loaded with therapeutic agents.BACKGROUNDContracting HIV (human immunodeficiency virus) can lead to lifelong complications both physically and mentally. Cu...
Published: 9/6/2019   |   Inventor(s): Jerome Zack, Scott Kitchen, Matthew Marsden, Michael Kovochich
Keywords(s): Drug Delivery, Infectious Diseases, Nanoparticles, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > infectious diseases, Drug Delivery > Nanoparticles, Drug Delivery, Therapeutics & Vaccines
2008-433 PROCESS FOR REDUCING SIZES OF EMULSION DROPLETS
Case No. 2008-433SUMMARYUCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of reducing sizes of droplets in multiple emulsion systems.BACKGROUNDThe process of extreme emulsification is used to make nanoscale emulsion droplets (radii <100 nm) by imposing an extreme flow using a high-pressure microfluidi...
Published: 9/6/2019   |   Inventor(s): Thomas Mason, Michael Fryd
Keywords(s): Drug Delivery, Nanoparticles, Nanotechnology
Category(s): Drug Delivery > Nanoparticles, Drug Delivery
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