Search Results - Drug+Delivery

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2020-133 NOVEL PROCESS FOR THE PEGYLATION OF LENTIVIRAL VECTORS
SUMMARYUCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed an improved method for the stabilization of Lentiviral Vectors: potentially increasing clinical efficacy of appropriate treatments. BACKGROUND: Gene therapy strategies offer the theoretical advantage of a durable clinical benefit to a myriad...
Published: 3/23/2022   |   Inventor(s): Donald Kohn
Keywords(s):  
Category(s): Drug Delivery, Drug Delivery > PEG, Drug Delivery > viral delivery systems
2020-444 NOVEL VAGINAL DRUG DELIVERY DEVICE - SECOND VERSION
SUMMARYUCLA researchers in the Departments of Biomedical Engineering and Medicine have developed vaginal drug delivery devices for the administration of contraceptives and antibiotics. BACKGROUND Globally, 1.9 billion women of reproductive age (15-49 years) use contraceptives. An additional 190 million women would use phrophylactics/contraceptives but...
Published: 12/27/2021   |   Inventor(s):  
Keywords(s):  
Category(s): Drug Delivery, Drug Delivery > Other polymers, Drug Delivery > Antibody delivery platforms
Optimized Lentiviral Vector for Stem Cell Gene Therapy of Hemoglobinopathies
SummaryUCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin.BackgroundSickle cell disease (SCD) is one of the...
Published: 12/21/2021   |   Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan
Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > gene editing systems, Therapeutics & Vaccines > gene therapy, Therapeutics & Vaccines > genetic disease, Drug Delivery, Drug Delivery > viral delivery systems, Life Science Research Tools > plasmids/vectors, Life Science Research Tools, Life Science Research Tools > research methods
2021-052 BOOST CARDIAC REPROGRAMMING BY MODULATING IMMUNE CELLS AND MICROENVIRONMENT
SUMMARYResearchers from the Department of Bioengineering at UCLA have identified key players in in both preventing and boosting cardiac reprogramming. This innovation can be used for in vivo human cardiac reprogramming to provide a novel approach for cardiac regeneration in the clinic and other fields of regenerative medicine. BACKGROUNDIschemic heart...
Published: 10/27/2021   |   Inventor(s): Song Li
Keywords(s):  
Category(s): Drug Delivery > Peptide base, Drug Delivery, Therapeutics & Vaccines, Therapeutics & Vaccines > cardiovascular, Drug Delivery > viral delivery systems
2020-908 LASER ACTUATED SUPERCRITICAL INJECTOR (LASI)
Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering developed a platform that applies high-speed fluidic jet injection of biomolecules into biological samples with the use of laser actuated supercritical injector (LASI). Background: Intracellular delivery of various biomolecules has been of great importance in biomedical...
Published: 8/10/2021   |   Inventor(s): Pei Yu Chiou
Keywords(s):  
Category(s): Nanotechnology, optics/photonics, other, Life Science Research Tools > microfluidics and mem's, Drug Delivery
2019-994 Targeted Drug Delivery with Near-IR Light
SUMMARY UCLA researchers in the Department of Materials Science and Engineering have developed a targeted drug delivery platform that can release drugs upon exposure to near-infrared light. BACKGROUND Stimuli-responsive delivery of drugs is an effective way to achieve spatially and temporally controlled drug release. Various stimuli-responsive...
Published: 7/16/2021   |   Inventor(s): Yang Yang, Dong Meng
Keywords(s):  
Category(s): Drug Delivery, optics/photonics, Electrical, Chemical, Chemical > chemical sensing, Chemical > Sensors, Medical Imaging, Medical Imaging > fluorescence
2021-001 COMBINATION CHEMO-IMMUNOTHERAPY FOR PANCREATIC CANCER USING THE IMMUNOGENIC EFFECTS OF AN IRINOTECAN SILICASOME NANOCARRIER PLUS ANTI-PD-1
SUMMARYUCLA researchers in the Department of Medicine have developed a combination therapy for pancreatic cancers using the irinotecan Silicasome nanocarrier and an anti-PD-1 antibody.BACKGROUND: Immune checkpoint inhibitors (ICIs) has shown promising therapeutic effects for the treatment of cancers such as renal and lung cancer. However, there has...
Published: 2/1/2021   |   Inventor(s): Andre Nel
Keywords(s):  
Category(s): Drug Delivery > Nanoparticles, Drug Delivery
2020-426 PRODRUGS OF PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN
Researchers at UCLA have developed prodrugs of peripherally-acting cannabinoid (PRCBs) receptor agonists for chronic pain relief. BACKGROUND: Cannabinoids are becoming prevalent in chronic pain treatments even though current marketed cannabinoid compounds may cause psychotropic effects or central nervous system (CNS)-mediated side effects. A potential...
Published: 12/10/2020   |   Inventor(s): Igor Spigelman, Alexander Spokoyny, Herbert Seltzman
Keywords(s): Cns, Drug Delivery, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > cns, Drug Delivery
2020-854 DUAL SELF-REGULATED DELIVERY OF INSULIN AND GLUCAGON BY A HYBRID PATCH
UCLA researchers have developed a novel hybrid microneedle patch that can deliver insulin and glucagon in a glucose-dependent manner. BACKGROUND: Type I diabetes (T1D) is an autoimmune disease in which pancreatic -cells are destroyed and there is a deficiency is insulin secretion. Type 2 diabetes (T2D) is a metabolic disorder resulting from insulin...
Published: 11/4/2020   |   Inventor(s): Zhen Gu
Keywords(s): Drug Delivery, Medical Devices and Materials, Metabolic Diseases, Other Polymers, Polymers, Therapeutics & Vaccines
Category(s): Drug Delivery, Drug Delivery > Other polymers, Therapeutics & Vaccines, Therapeutics & Vaccines > metabolic diseases, Medical Devices and Materials
2020-784 DEVELOPMENT OF A STING DELIVERING NANOPARTICLE FOR IMMUNOTHERAPY OF CANCER METASTASES TO THE LIVER
UCLA researchers in the Department of Nanomedicine have developed antigen presenting cells (APCs) targeting nanoparticles to deliver STING (stimulator of interferon genes) agonists to the liver for metastatic cancer treatment. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and estimated to become the second leading...
Published: 9/28/2020   |   Inventor(s): Andre Nel
Keywords(s): Drug Delivery, Immunotherapy, Nanoparticles, Oncology, Therapeutics & Vaccines
Category(s): Drug Delivery, Drug Delivery > Nanoparticles, Nanotechnology, Therapeutics & Vaccines, Therapeutics & Vaccines > immunotherapy, Therapeutics & Vaccines > oncology, Therapeutics & Vaccines > oncology immunotherapy
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