Search Results - Therapeutics & Vaccines

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2006-064 DESIGNING AN IMPROVED KUNITZ DOMAIN 1 OF TFPI-2 MOLECULE FOR THERAPEUTICS
Improved Highly Potent Specific Human Kunitz Inhibitor of Fibrinolytic Enzyme PlasminTech ID: 30531 / UC Case 2019-981-0SUMMARYUCLA researchers in the School of Medicine have developed mutant polypeptides of the tissue factor pathway inhibitor-2 (TFPI-2) Kunitz domain 1 (KD1), which can serve as potent inhibitors of fibrinolysis.BACKGROUNDFibrinoly...
Published: 9/16/2019   |   Inventor(s):  
Keywords(s): Hematology, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > hematology, Therapeutics & Vaccines
2018-749 A METHOD TO DISTINGUISH DIFFERENT RETROVIRAL VECTORS DURING INTEGRATION SITE ANALYSIS
UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel gene therapy vector identifying method, capable of screening toxicities of combination therapies.TITLE: A Method to Distinguish Different Retroviral Vectors During Integration Site Analysis BACKGROUND: Many diseases originate from defective...
Published: 9/11/2019   |   Inventor(s): Irvin S.Y. Chen, Gajendra Suryawanshi, Sanggu Kim
Keywords(s): Gene Editing Systems, Gene Therapy, Life Science Research Tools, Plasmids / Vectors, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > gene editing systems, Therapeutics & Vaccines > gene therapy, Life Science Research Tools, Life Science Research Tools > plasmids/vectors
Netrin-1 Peptides for the Treatment of Pulmonary Hypertension
INTRO SENTENCE:UCLA researchers in the Department Anesthesiology & Perioperative Medicine have developed a treatment for pulmonary hypertension. BACKGROUND:Pulmonary hypertension (PH) causes increased blood pressure and affects the arteries of the lungs and heart. Common symptoms include: shortness of breath, fatigue, chest pressure or pain, an...
Published: 9/10/2019   |   Inventor(s): Hua Linda Cai
Keywords(s): Cardiovascular, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > cardiovascular, Therapeutics & Vaccines
Novel Superior Peptides for the Treatment of Myocardial Infarction
INTRO SENTENCE: UCLA researchers in the department of Anesthesiology have developed a series of peptides that are capable of treatment of Myocardial Infarction (Heart Attack). BACKGROUND: Myocardial Infarction (MI), is the medical term for heart attack, which has been estimated to affect 7.9 million Americans annually. Approximately every 25 seco...
Published: 9/10/2019   |   Inventor(s):  
Keywords(s): Cardiovascular, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > cardiovascular, Therapeutics & Vaccines
2019-600 TREATMENT FOR RESTORING UREAGENESIS IN CARBAMOYL PHOSPHATE SYNTHETASE 1 DEFICIENCY
Treatment for Restoring Ureagenesis in Carbamoyl Phosphate Synthetase 1 DeficiencyTech ID: 30356 / UC Case 2019-600-0SUMMARYUCLA researchers in the Department of Surgery have developed a gene therapy to treat carbamoyl phosphate synthetase 1 deficiency.BACKGROUNDCarbamoyl phosphate synthetase 1 (CPS1) deficiency is an inherited autosomal recessive ...
Published: 9/6/2019   |   Inventor(s): Gerald Lipshutz
Keywords(s): Cns, Gene Editing Systems, Gene Therapy, Genetic Disease, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > cns, Therapeutics & Vaccines > gene therapy, Therapeutics & Vaccines > gene editing systems, Therapeutics & Vaccines > genetic disease, Therapeutics & Vaccines
2019-550 A METHOD TO PREVENT THE MYELIN ABNORMALITES ASSOCIATED WITH ARGINASE DEFICIENCY
A Method to Prevent the Myelin Abnormalities Associated with Arginase DeficiencyTech ID: 30363 / UC Case 2019-550-0SUMMARYUCLA researchers in the Department of Surgery have developed a gene therapy to prevent dysmyelination (and other CNS abnormalities) as a result of arginase deficiency.BACKGROUNDArginase deficiency (ARG1 deficiency, argininemia) ...
Published: 9/6/2019   |   Inventor(s): Gerald Lipshutz
Keywords(s): Cns, Gene Editing Systems, Gene Therapy, Genetic Disease, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > cns, Therapeutics & Vaccines > gene therapy, Therapeutics & Vaccines > gene editing systems, Therapeutics & Vaccines > genetic disease, Therapeutics & Vaccines
2019-279 IDENTIFICATION AND DEVELOPMENT OF DUAL NSMASE2- ACHE INHIBITORS FOR NEURODEGENERATIVE DISORDERS
Identification And Development Of Dual nSMase2-AChE Inhibitors For Neurodegenerative DisordersTech ID: 30193 / UC Case 2019-279-0SUMMARYUCLA researchers in the Department of Neurology, and the Department of Chemistry & Biochemistry have developed small molecule inhibitors of both the neutral sphingomyelinase 2 (nSMase2) and acetylcholinesterase...
Published: 9/6/2019   |   Inventor(s):  
Keywords(s): Cns, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > cns, Therapeutics & Vaccines
2019-336 CARBORANE-BASED HISTONE DEACETYLASE (HDAC) INHIBITORS
Carborane-Based Histone Deacetylase (HDAC) InhibitorsTech ID: 30179 / UC Case 2019-336-0SUMMARYUCLA researchers from the Department of Chemistry & Biochemistry have developed a new class of Histone Deacetylase (HDAC) inhibitors that can be tuned for isoform specificity and other properties.BACKGROUNDHistone Deacetylase (HDAC) is a ubiquitous en...
Published: 9/6/2019   |   Inventor(s):  
Keywords(s): Cns, Life Science Research Tools, Other Reagents, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > cns, Life Science Research Tools, Therapeutics & Vaccines, Life Science Research Tools > other reagents
2018-465 ANTIBODY-FREE PROTOCOL FOR GENERATION OF HIGHLY EXPANDABLE, NON-FIBROADIPOGENIC MESODERMAL PRECURSORS FROMHUMAN PLURIPOTENT STEM CELLS FOR TREATMENT
Antibody-Free Protocol For Generation Of Highly Expandable, Non-Fibroadipogenic Mesodermal Precursors from Human Pluripotent Stem Cells For TreatmentTech ID: 30170 / UC Case 2018-465-0SUMMARYUCLA researchers in the Department of Orthopaedic Surgery have developed a novel method to generate mesodermal precursors from human pluripotent stem cells to ...
Published: 9/6/2019   |   Inventor(s): Ayelet Dar, Bruno Peault, Frank Petrigliano
Keywords(s): Musculoskeletal Disease, Stem Cells / Regenerative Medicine, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > stem cells / regenerative medicine, Therapeutics & Vaccines, Therapeutics & Vaccines > Musculoskeletal Disease
PAK4 in Cancer Immune Exclusion
Case 2018-209Researchers at the UCLA David Geffen School of Medicine have proposed that T cell tumor infiltration and the anti-tumor activity of anti-PD-1/PD-L1-based immunotherapy to be modulated through kinase PAK4 activity. BACKGROUNDThe p21-activated kinase 4 (PAK4) is a member of the PAK family of serine/threonine kinases, which are importan...
Published: 9/6/2019   |   Inventor(s): Antoni Ribas, Catherine Grasso
Keywords(s): Immunotherapy, Life Science Research Tools, Medical Devices and Materials, Oncology, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines, Medical Devices and Materials, Life Science Research Tools, Therapeutics & Vaccines > immunotherapy, oncology
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