Search Results - Therapeutics+%26+Vaccines

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2021-272: APOA-I Mimetic Peptides as Antiviral Therapeutic Strategy
SUMMARY: Researchers from UCLA’s Department of Medicine have developed an oral antiviral using the apoA-I mimetic peptide 4F alone or in combination with statins to prevent and treat infection of SARS-CoV-2, including long-term post-infection symptoms. ApoA-I mimetic peptides can also be given systemically as injection to attenuate viral replication...
Published: 8/4/2022   |   Inventor(s): Theodoros Kelesidis
Keywords(s):  
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > infectious diseases, COVID
2022-057 NEW TREATMENT FOR SJOGREN'S SYNDROME
SUMMARY: UCLA researchers in the Department of Molecular and Medical Pharmacology have identified a novel and safe therapeutic to ameliorate symptoms for the autoimmune disorder, Sjögren’s Syndrome. BACKGROUND: Sjögren’s syndrome (SS) is an autoimmune disorder that affects over 4 million people in the United States. Most commonly,...
Published: 7/26/2022   |   Inventor(s): Daniel Kaufman
Keywords(s):  
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > autoimmune, Therapeutics & Vaccines > inflammatory diseases
2022-177: DRUG COMBINATION TO INHIBIT BOTH MPRO AND PLPRO PROTEASES OF SARS-COV-2
SUMMARYUCLA researchers in the Department of Neurology have developed a novel small-molecule protease inhibitor cocktail to robustly suppress COVID-19 infection.INTRODUCTIONCOVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Despite the development of vaccines, COVID-19 was the third-leading cause of death in the U.S. in 2021, highlighting...
Published: 5/5/2022   |   Inventor(s): Varghese John
Keywords(s):  
Category(s): COVID, Therapeutics & Vaccines, Therapeutics & Vaccines > infectious diseases
2021-354 A MULTI-MODAL CRYPTO/BIO-HUMAN-MACHINE INTERFACE
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an instrument that detects and encrypts a user’s biochemical and biometric data with only a touch of the finger. Background: Human machine interfaces (HMI), such as touchscreens and keyboards, are able to connect users to machines, systems, and...
Published: 3/28/2022   |   Inventor(s): Sam Emaminejad, Shuyu Lin, Jialun Zhu, Wenzhuo Yu
Keywords(s): Bioinformatics, Biosensor, Biotechnology, Computer Security, Digital Health, Sensor, Software & Algorithms
Category(s): Medical Devices and Materials > monitoring and recording systems, Software & Algorithms > Bioinformatics, Software & Algorithms > Digital Health, Software & Algorithms > software, Therapeutics & Vaccines, Mechanical > Sensors, Electrical > Sensors, Diagnostic Markers & Platforms > diagnostic platform technologies (e.g. microfluidics), Chemical > Sensors
2020-889 293T PACKAGING CELLS WITH TARGETED GENE KNOCKOUTS THAT IMPROVE LENTIVIRAL VECTOR TITERS
INTRODUCTIONUCLA researchers in the Department of Microbiology, Immunology, & Molecular Genetics have found that the knockout of four host cell antiviral factors could increase lentiviral titers, allowing the potential to reduce common off target toxicities of gene therapy while lowering the cost of treatment manufacturing. BACKGROUNDGene therapy...
Published: 3/18/2022   |   Inventor(s): Donald Kohn
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > cell lines, Therapeutics & Vaccines, Therapeutics & Vaccines > gene editing systems
2022-070: HUMAN T CELL RECEPTOR PAIRS REACTIVE WITH HLA-A*02:01 RESTRICTED HUMAN PROSTATIC ACID PHOSPHATASE (PAP) EPITOPES
SUMMARY: Researchers from UCLA's Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...
Published: 2/28/2022   |   Inventor(s): Owen Witte, Zhiyuan Mao, Jami Witte, Pavlo Nesterenko, John Lee
Keywords(s):  
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > oncology immunotherapy, Therapeutics & Vaccines > oncology, Therapeutics & Vaccines > immunotherapy
2020-500 SEPARATION OF THE ANALGESIC AND ADDICTIVE CONSEQUENCES OF OPIATE ADMINISTRATION
SUMMARY: UCLA researchers in the Department of Psychiatry have discovered a novel approach that decreases the additive response of patients to opiates, but maintains their potent pain relief property. BACKGROUND: Prescription opioids are commonly prescribed by medical doctors to treat symptoms of severe pain. Opioids function by binding and activating...
Published: 2/22/2022   |   Inventor(s): Jerome Siegel, Ronald McGregor, Frank Wu
Keywords(s):  
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > cns, Therapeutics & Vaccines > anesthesiology
2022-082: IDENTIFICATION OF A PLATFORM TO IDENTIFY TUMOR-SPECIFIC T CELL RECEPTORS
SUMMARY: Researchers from UCLA’s Department of Neurosurgery and Pharmacology have developed a rapid discovery platform for the identification of tumor-specific T cell receptors to aid in more personalized and potent immunotherapy for glioblastoma. BACKGROUND: Over the past several years, immunotherapy, or therapies that enlist and strengthen...
Published: 2/22/2022   |   Inventor(s): Robert Prins, Alexander Lee, Lu Sun, David Nathanson
Keywords(s):  
Category(s): Therapeutics & Vaccines > cns, Therapeutics & Vaccines, Therapeutics & Vaccines > immunotherapy, Therapeutics & Vaccines > oncology, Therapeutics & Vaccines > oncology immunotherapy
2021-182: COMBINING AUTOLOGOUS OR ALLOGENEIC TOTAL MONOCYTES OR CD16+ MONOCYTES TO PROTECT AND INCREASE THE EXPANSION AND FUNCTION OF STEM CELLS.
SUMMARY: UCLA researchers in the department of Dentistry have developed a novel approach to increase the successful transplantation and survival of stem cells into patients. BACKGROUND: The World Health Organization has recognized that transplantation of human cells saves and restores essential life functions to patients who are not presented with...
Published: 1/28/2022   |   Inventor(s): Anahid Jewett
Keywords(s):  
Category(s): Therapeutics & Vaccines > iPS/stem cells, Therapeutics & Vaccines > immunotherapy, Therapeutics & Vaccines, Therapeutics & Vaccines > stem cells / regenerative medicine, Therapeutics & Vaccines > cns
2021-129 USE OF COX2 KNOCK OUT MONOCYTES AND OSTEOCLASTS TO ACTIVATE AND EXPAND NK CELLS
SUMMARY: UCLA Researchers in the Department of Dentistry have developed a procedure to increase immune response in cancer patients. BACKGROUND: Natural killer (NK) cells are a type of cytotoxic lymphocyte critical to the innate immune system. NK cells provide rapid responses to viral infection and are also crucial to inhibiting tumor formation. They...
Published: 1/28/2022   |   Inventor(s): Anahid Jewett
Keywords(s):  
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > immunotherapy, Therapeutics & Vaccines > oncology, Therapeutics & Vaccines > oncology immunotherapy
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