Search Results - Therapeutics & Vaccines

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2020-426 PRODRUGS OF PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN
Researchers at UCLA have developed prodrugs of peripherally-acting cannabinoid (PRCBs) receptor agonists for chronic pain relief. BACKGROUND: Cannabinoids are becoming prevalent in chronic pain treatments even though current marketed cannabinoid compounds may cause psychotropic effects or central nervous system (CNS)-mediated side effects. A potential...
Published: 12/10/2020   |   Inventor(s): Igor Spigelman, Alexander Spokoyny, Herbert Seltzman
Keywords(s): Cns, Drug Delivery, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > cns, Drug Delivery
2020-854 DUAL SELF-REGULATED DELIVERY OF INSULIN AND GLUCAGON BY A HYBRID PATCH
UCLA researchers have developed a novel hybrid microneedle patch that can deliver insulin and glucagon in a glucose-dependent manner. BACKGROUND: Type I diabetes (T1D) is an autoimmune disease in which pancreatic -cells are destroyed and there is a deficiency is insulin secretion. Type 2 diabetes (T2D) is a metabolic disorder resulting from insulin...
Published: 11/4/2020   |   Inventor(s): Zhen Gu
Keywords(s): Drug Delivery, Medical Devices and Materials, Metabolic Diseases, Other Polymers, Polymers, Therapeutics & Vaccines
Category(s): Drug Delivery, Drug Delivery > Other polymers, Therapeutics & Vaccines, Therapeutics & Vaccines > metabolic diseases, Medical Devices and Materials
2020-784 DEVELOPMENT OF A STING DELIVERING NANOPARTICLE FOR IMMUNOTHERAPY OF CANCER METASTASES TO THE LIVER
UCLA researchers in the Department of Nanomedicine have developed antigen presenting cells (APCs) targeting nanoparticles to deliver STING (stimulator of interferon genes) agonists to the liver for metastatic cancer treatment. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and estimated to become the second leading...
Published: 9/28/2020   |   Inventor(s): Andre Nel
Keywords(s): Drug Delivery, Immunotherapy, Nanoparticles, Oncology, Therapeutics & Vaccines
Category(s): Drug Delivery, Drug Delivery > Nanoparticles, Nanotechnology, Therapeutics & Vaccines, Therapeutics & Vaccines > immunotherapy, Therapeutics & Vaccines > oncology, Therapeutics & Vaccines > oncology immunotherapy
2020-408 SAPPALPHA TAREGETED THERAPEUTICS FOR ALZHEIMER’S DISEASE
UCLA researchers from the Department of Neurology have developed a novel application of two compounds that target the upstream formation of toxic amyloid-beta oligomers for the effective treatment of Alzheimer’s disease. BACKGROUND: Alzheimer’s Disease (AD) is the most common age-related neurodegenerative disorder currently affecting ~6...
Published: 9/28/2020   |   Inventor(s): Varghese John, Sujyoti Chandra
Keywords(s): Chemical, Cns, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > cns, Therapeutics & Vaccines
2018-384 ANTIBODY-INTERFERON FUSION PROTEINS FOR ENHANCING ADOPTIVE T CELL THERAPIES FOR THE TREATMENT OF CANCER
UCLA researchers in the Departments of Medicine and Microbiology, Immunology and Molecular Genetics have developed a novel combination therapy for enhanced efficacy of Adoptive T Cell Therapies (ACT): that could enable the adoption of ACT as an effective means to combat multiple cancer subtypes. BACKGROUND:The clinical relevancy of cancer immunotherapy...
Published: 9/3/2020   |   Inventor(s): John Timmerman, Patricia Young, Kham (Ryan) Trinh, Sherie Morrison
Keywords(s): Diagnostic Markers & Platforms, Oncology, Therapeutics & Vaccines
Category(s): Diagnostic Markers & Platforms, Therapeutics & Vaccines, Therapeutics & Vaccines > oncology
2020-777 CORRECTING NEURONAL DYSFUNCTION IN INTELLECTUAL DISABILITY SYNDROMES
UCLA researchers in the department of Molecular, Cellular, and Developmental Biology have developed a treatment that could mitigate some mental issues related to various intellectual disabilities syndromes. BACKGROUND: Approximately 6.5 million people in the United states have an intellectual disability syndrome, classified as an IQ of less than 70....
Published: 8/7/2020   |   Inventor(s): William Lowry
Keywords(s): Cns, Genetic Disease, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > genetic disease, Therapeutics & Vaccines > cns, Therapeutics & Vaccines
2019-693 IDENTIFICATION OF A PLATFORM FOR T CELL RECEPTOR RECOGNITION OF SPLICE VARIATION NEOANTIGENS IN GLIOBLASTOMA
UCLA researchers in the Departments of Neurosurgery and Pharmacology have developed a novel platform for the identification of alternative splice variants unique to cancer cells, for use as neo-epitope vaccines or as T cell Receptor-based cell therapy of brain cancer. BACKGROUND:T cells are a type of lymphocyte that play a central role in immune response...
Published: 6/3/2020   |   Inventor(s): Robert Prins, Yi Xing
Keywords(s): Diagnostic Markers & Platforms, Oncology, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > oncology immunotherapy, Therapeutics & Vaccines, Diagnostic Markers & Platforms
2018-179 Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection
Generation Of A Live Attenuated Influenza Vaccine That Elicits Broad ProtectionSUMMARYUCLA researchers in the Department of Microbiology, Immunology & Molecular Genetic and the Molecular Biology Institute have developed a novel method of generating highly efficacious and live attenuated influenza vaccines.BACKGROUNDThe market for human influenza...
Published: 3/31/2020   |   Inventor(s): Genhong Cheng, Su-Yang Liu, Xiao-Feng Qin
Keywords(s): Immunotherapy, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines, Therapeutics & Vaccines > infectious diseases, Life Science Research Tools, Therapeutics & Vaccines > immunotherapy
2017-798 Virtual Reality Training Tasks Used For Stroke Rehabilitation
SUMMARYUCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a set of virtual reality training tasks that can be used for rehabilitation for post-stroke patients.BACKGROUNDStroke is a leading cause of death and disability around the world, and the majority of survivors experience chronic motor deficits. Considerable...
Published: 2/28/2020   |   Inventor(s): Yang Shen, Jacob Rosen
Keywords(s): Mechanical Systems, Musculoskeletal Disease, Robotics, Software & Algorithms, Therapeutics & Vaccines
Category(s): Mechanical > Mechanical Systems, Mechanical > robotics, engines, turbines, aerospace, MEM's, Software & Algorithms > training systems, Software & Algorithms, Therapeutics & Vaccines, Therapeutics & Vaccines > Musculoskeletal Disease
2016-592 CATALYTIC MICRORNA ANTAGONISTS
Catalytic MicroRNA AntagonistsSUMMARYUCLA researchers in the Department of Biological Chemistry have developed a novel approach for miRNA inhibition.BACKGROUNDMicro RNA (miRNA) are short, 22 nucleotide RNA sequences. They play a critical role in post-transcription gene regulation and their mis-regulation is associated with different diseases such as...
Published: 2/28/2020   |   Inventor(s): Feng Guo
Keywords(s): Autoimmune, Therapeutics & Vaccines
Category(s): Therapeutics & Vaccines > autoimmune, Therapeutics & Vaccines
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