Search Results - cancer

14 Results

Sort By:

Novel Anti-mesothelin CAR for Use in Engineered Cell Therapies (UCLA Case No. 2023-281)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a nanobody-based CAR T cell platform with increased stability and cross-immunogenicity between human and mouse antigens. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered T cells to target and clear cancer cells....

Published: 3/6/2024 | Inventor(s): Yvonne Chen

Keywords(s): Cancer, CAR-T cell platform, CAR-T cell therapy, cell engineering, Immunotherapy, Mesothelin, nanobody, Nanoparticle

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)

Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...

Published: 2/26/2024 | Inventor(s): Owen Witte, Zhiyuan Mao, Jami Witte, Pavlo Nesterenko, John Lee

Keywords(s): Cancer, cancer antigen, Peptide, peptides, prostate cancer, protein, t-cells

Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

New Fusion Molecule Based on Novel TAA Variant (UCLA Case No. 2007-217)

BACKGROUND: Renal cell carcinoma (RCC) affects approximately 39,000 Americans and causes an estimated 13,000 deaths per year. Metastatic RCC poses a therapeutic challenge because of its resistance to conventional modes of therapy. Approximately one third of RCC patients will present at the metastatic stage and one third of patients with localized disease...

Published: 2/16/2024 | Inventor(s): Arie Belldegrun, Zhenhua Li

Keywords(s): Cancer, Immunotherapy, Renal, Renal cell carcinoma, renal diseases

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Renal

Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)

UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...

Published: 1/17/2024 | Inventor(s): Serendipity Zapanta Rinonos, Albert Lai

Keywords(s): Brain, Cancer, Cancer stem cells, Chemotherapy, Combination therapy, CRISPR, CRISPR-Cas9, Epigenetics, GBM, Glioma

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology

Interactive Reporting of Histopathological Image Analysis Performed by Artificial Intelligence (UCLA Case No. 2023-090)

Summary: Researchers from UCLA's Departments of Electrical and Computer Engineering and Pathology and Laboratory Medicine, along with a researcher from KUMC's Department of Pathology and Laboratory Medicine, have developed an innovative workflow for pathology, integrating artificial intelligence (AI) diagnostics with interactive reporting. Background: The...

Published: 11/28/2023 | Inventor(s): Xiang Chen, Hongyan Gu, Mohammad Haeri, Shino Magaki

Keywords(s): 2. Medical science computing, algorithmic cancer detection, Cancer, cancer detection, Computer Aided Learning, Digital Health, Digital Holography, Digital immunohistology, Digital Pathology, Histology, Histopathological image analysis, Histopathology, Immunohistochemistry

Category(s): Medical Devices, Medical Devices > Medical Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing

2022-291: Methods for Identifying and Correcting Tumor Humoral Immune Dysfunction

UCLA researchers in the Department of Bioengineering have developed a platform advancing systems serology that profiles the Fc properties of anti-tumor antibodies (ATAbs) to provide more nuanced understanding of a cancer’s humoral immunity and better guide therapeutic approaches towards overcoming the immune dysregulation. BACKGROUND: Antibodies...

Published: 2/15/2024 | Inventor(s): Aaron Meyer

Keywords(s): antibody Fc profiling, Anti-tumor antibodies, anti-tumor immune response, ATAbs, Cancer, immune evasion, Oncology, systems serology

Category(s): Diagnostic Markers > Cancer, Platforms > Diagnostic Platform Technologies

Syringe Stabilization Device for Ultrasound-Guided Procedures (UCLA Case No. 2023-045)

Summary: UCLA researchers in the Department of Surgery have developed a novel, minimally invasive ultra-sounded guided metastatic mouse model and device enabling more secure and precise usage of in-plane ultrasound imaging of needles. Background: Cancer is the second leading cause of death globally and in the United States. Pancreatic cancer remains...

Published: 11/8/2023 | Inventor(s): Amanda Labora

Keywords(s): Breast Cancer, Cancer, cancer detection, Cancer Immunotherapy, Catheterization, In-plane ultrasound, Intratumoral drug delivery, Metastasis, metastatic mouse model, Mouse model, Orthotopic cancer models, Pancreatic cancer, Preclinical model development, Preclinical surgical innovation

Category(s): Life Science Research Tools, Life Science Research Tools > Animal Imaging, Life Science Research Tools > Animal Models, Medical Devices > Medical Imaging, Therapeutics, Therapeutics > Oncology, Medical Devices > Medical Imaging > Ultrasound

Novel Method to Group Pixels for Medical Imaging (UCLA Case No. 2022-290)

Summary: UCLA researchers in the Department of Radiological Sciences have developed a new computational pipeline for identifying lesions in MRI data. Background: Prostate cancer is one of the most common cancer types with 12.6% of men diagnosed within their lifetime. Prostate cancer ranks as the 2nd leading cause of cancer-related deaths in the...

Published: 7/31/2023 | Inventor(s): Ashley Yeager

Keywords(s): AI algorithms, Algorithm, algorithmic cancer detection, Cancer, cancer detection, DICOM, multiparametric MRI (mpMRI), prostate cancer, Radiology, Software & Algorithms, Tumor, Tumor Marker

Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Digital Health

2022-067 Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a simple, innovative method for growing 3D cell cultures with improved organoid differentiation and reduced hypoxia-induced cell death. TITLE: Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues Background: 3D tissue culture,...

Published: 4/5/2024 | Inventor(s): Neil Lin, Marie Payne

Keywords(s): 3D Printing, Biofilm, Biomaterial 3D Printing, Biomedical Engineering, Cancer, cancer detection, Cancer Immunotherapy, Cell and tissue culture, Cell Culture, Cellular agriculture, Cultured meat, iPS/stem cells, Laminar flow, Microwell plates, organogenesis, Organoids, Personalized Pharmacotherapy, Pharmaceutical testing, Stem Cells / Regenerative Medicine, Tissue (Biology), tissue detection, Tissue Engineering, Tissue sedimentation

Category(s): Life Science Research Tools > Lab Equipment, Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Therapeutics, Therapeutics > Oncology

2023-009: Repurposing Native Cytokine Receptor Signaling for Adoptive T Cell Therapy of Cancer

SUMMARY: UCLA researchers in the Department of Radiation Oncology at the School of Medicine have identified a cytokine receptor endowing adoptively transferred T cells with new functions that enhance the potency of adoptively transferred T cells for the treatment of solid tumors, namely by restoring their functionality in the absence of conditioning...

Published: 7/19/2023 | Inventor(s): Anusha Kalbasi

Keywords(s): Cancer, Immunotherapy, Tumor

Category(s): Life Science Research Tools, Therapeutics

1 2