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A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)

Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...

Published: 1/24/2024 | Inventor(s): Rhonda Voskuhl, Michael Jung

Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics

2014-287 Minimally Invasive Implantable Brain Stimulation Devices And Methods For Implanting Same

SUMMARYUCLA researchers in the Department of Neurosurgery have developed a novel, minimally invasive deep-brain stimulation device concept.BACKGROUNDFor many patients suffering from a variety of movement and neuropsychiatric disorders, deep-brain stimulation (DBS) of select brain areas provides lasting relief for otherwise-treatment-resistant cases....

Published: 7/19/2023 | Inventor(s): Itzhak Fried, Ilan Ben Oren, Tamir Wolf

Keywords(s): Cns, Medical Devices and Materials, Psychiatry / Mental Health

Category(s): Medical Devices, Therapeutics > CNS and Neurology, Therapeutics > Psychiatry And Mental Health

2020-426 PRODRUGS OF PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN

Researchers at UCLA have developed prodrugs of peripherally-acting cannabinoid (PRCBs) receptor agonists for chronic pain relief. BACKGROUND: Cannabinoids are becoming prevalent in chronic pain treatments even though current marketed cannabinoid compounds may cause psychotropic effects or central nervous system (CNS)-mediated side effects. A potential...

Published: 9/5/2023 | Inventor(s): Igor Spigelman, Alexander Spokoyny, Herbert Seltzman

Keywords(s): Cns, Drug Delivery, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > CNS and Neurology

2020-408: sAPPalpha Targeted Therapeutics for Alzheimer’s Disease

UCLA researchers from the Department of Neurology have developed a novel application of two compounds that target the upstream formation of toxic amyloid-beta oligomers for the effective treatment of Alzheimer’s disease. BACKGROUND: Alzheimer’s Disease (AD) is the most common age-related neurodegenerative disorder currently affecting ~6...

Published: 7/19/2023 | Inventor(s): Varghese John, Sujyoti Chandra

Keywords(s): Chemical, Cns, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > CNS and Neurology

2020-120 NOVEL MOUSE MODELS FOR GENETICALLY-DIRECTED SPARSE AND COMPLETE LABELING OF BRAIN CELLS FOR ANALYSIS OF BRAIN CELL BIOLOGY AND PATHOLOGY

Researchers in the Jane and Terry Semel Institute for Neuroscience and Human Behaviors at UCLA have developed four novel reporter mouse lines that illuminate morphologies of genetically-defined neurons and glia and can serve as novel platform for testing candidate therapeutics for neurodevelopmental, psychiatric and age-related brain diseases. The tools...

Published: 7/19/2023 | Inventor(s): William Yang

Keywords(s): Animal Models, Cns, Diagnostic Markers & Platforms, Life Science Research Tools

Category(s): Life Science Research Tools > Animal Models, Platforms > Diagnostic Platform Technologies, Therapeutics > CNS and Neurology

2019-341: Microbiome-Based Regulation of Cognitive Behavior

UCLA researchers in the Department of Integrative Biology & Physiology have discovered select bacterial factors that can be targeted to promote hippocampal functions and cognitive behaviors. BACKGROUND: Cognitive impairment, characterized by deficient attention, causal reasoning, and learning and memory, is a pressing public health concern, afflicting...

Published: 7/19/2023 | Inventor(s): Elaine Hsiao

Keywords(s): Cns, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology

2020-777: Correcting Neuronal Dysfunction in Intellectual Disability Syndromes

UCLA researchers in the department of Molecular, Cellular, and Developmental Biology have developed a treatment that could mitigate some mental issues related to various intellectual disabilities syndromes. BACKGROUND: Approximately 6.5 million people in the United states have an intellectual disability syndrome, classified as an IQ of less than 70....

Published: 9/20/2023 | Inventor(s): William Lowry

Keywords(s): Cns, Genetic Disease, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > CNS and Neurology

2019-720: Preventing Senescence to Improve Neuronal Function in Intellectual Disability Disorders

UCLA researchers in the Department of Molecular and Cell & Developmental Biology have developed novel therapeutic strategy to treat intellectual disability disorders discovered via a screening platform for drug discovery in a human model of brain development. BACKGROUND: Rett syndrome is an X-linked genetic neurological disease associated...

Published: 9/20/2023 | Inventor(s): William Lowry

Keywords(s): Cns, Genetic Disease, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology

2017-977 Load-Induced Frequency-Shift-Keying: A New Modulation Scheme That Enables Simultaneous Near-Field Wireless Power And Data Transmission Through A Single Set of Inductive Coils

SUMMARYUCLA researchers in the Department of Electrical Engineering have developed the first modulation system that allows simultaneous wireless power and data transmission through a single pair of inductive coils.BACKGROUNDNext-generation Brain-Machine Interface senses neural data and stimulates the brain when needed, which requires simultaneous external...

Published: 7/19/2023 | Inventor(s): Asad Abidi, Dejan Markovic, Jiacheng Pan

Keywords(s): Antennas/Wireless, Cns, Electronics & Semiconductors, Medical Devices and Materials, Monitoring And Recording Systems, Psychiatry / Mental Health

Category(s): Electrical > Electronics & Semiconductors, Electrical > Electronics & Semiconductors > Circuits, Electrical > Quantum Computing, Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics > CNS and Neurology, Therapeutics > Psychiatry And Mental Health, Electrical > Wireless

2019-880 ZIKA VIRUS-BASED ONCOLYTIC THERAPY FOR BRAIN CANCER

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a novel zika virus-based oncolytic therapy to treat brain cancer.BACKGROUND: Glioma is a type of brain tumor that accounts for 80% of all primary malignant brain tumors. Standard therapy for high-grade glioma requires a combination of surgical resection, radiation...

Published: 9/12/2023 | Inventor(s): Vaithilingaraja Arumugaswami, David Nathanson

Keywords(s): Cns, Drug Delivery, Gene Editing Systems, Gene Therapy, Immunology, Immunotherapy, Oncology, Oncology Immunotherapy, Plasmids / Vectors, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Diagnostic Markers > Immunology, Therapeutics > CNS and Neurology, Therapeutics > Vaccines, Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing, Therapeutics > Oncology > Oncology Immunotherapy

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