Search Results - drug+delivery

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Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)

UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...

Published: 2/26/2024 | Inventor(s): Sherie Morrison, John Timmerman, Kham (Ryan) Trinh

Keywords(s): Antibody Delivery Platforms, Drug Delivery, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Life Science Research Tools, Therapeutics > Immunology And Immunotherapy

Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)

Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...

Published: 2/26/2024 | Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu (Rayne) Zheng

Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers

Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease

2022-223 A Bioanalytics-Enabled and Hollow Microneedle-Based Wearable Technology for Personalized Medicine

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a minimally-invasive wearable device that continuously monitors pharmaceutical concentrations in a user to optimize the drug’s dosage. Background: The annual cost of medication-related morbidity and mortality due to non-optimized pharmacotherapy...

Published: 7/19/2023 | Inventor(s): Sam Emaminejad, Shuyu Lin

Keywords(s): Adverse Drug Reaction, Antibody-Drug Conjugate, Antiviral Drug, Biomonitoring, Blood Glucose Monitoring, Drug, Drug Carrier, Drug Delivery, Drug Delivery Microporous Material, Drug Development, Drug Development Feature Extraction, Drug Discovery, Drug monitoring, Drug Resistance, Drug-Eluting Stent, Extensively Drug-Resistant Tuberculosis, Fine-Needle Aspiration, Gene Combination Drug, Immunosuppressive Drug, interstitial fluid (ISF)-based information, Investigatioal New Drug, Management Of HIV/AIDS Psychoactive Drug, medical automation technology, Medical Device, Medical Devices and Materials, medication customization, medication efficacy, Microneedle array, minimally invasive device, Monitoring (Medicine), Monitoring And Recording Systems, Multiple Drug Resistance, Mutation Drug Design, Nanosensor, Nanostructure, Nanotechnology, non-invasive drug monitoring, personalized dose assessment, Pharmaceutical Drug, Pharmaceutical Drug Ethylene Glycol, Pharmaceutical Drug Opioid Dependence, Prescription Drug, real-time sensing/monitoring/tracking, remote monitoring, sample-to-answer devices, Smart medical device, Therapeutic Drug Monitoring, wearable medical device

Category(s): Mechanical, Mechanical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms > Drug Delivery, Software & Algorithms > Bioinformatics, Software & Algorithms > Artificial Intelligence & Machine Learning, Electrical > Sensors, Materials > Nanotechnology

2020-922 A Universal Designed Protein Cage for Sensing and Responding to Any Other Protein Molecule

SUMMARY: UCLA researchers in the Department of Chemistry and Biochemistry have designed and developed a protein cage which can be easily tailored to sense other proteins, opening in response, and thus delivering enclosed biological compounds across a wide variety of applications, including biosensing, molecular diagnostics, and targeted drug delivery....

Published: 9/5/2023 | Inventor(s): Todd Yeates

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Drug Delivery

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nanoparticles, Platforms > Drug Delivery > Nucleic Acids

2022-222 A Wearable Aptamer Microneedle Patch for Continuous Minimally-Invasive Biomonitoring

Summary: UCLA researchers in the Department of Bioengineering have developed a novel wearable device for real-time, minimally-invasive medication monitoring. Background: Current medication dosing is determined by taking the average therapeutic dose of a small patient sample size. However, this is often inaccurate for many individuals and the recommended...

Published: 7/19/2023 | Inventor(s): Sam Emaminejad, Shuyu Lin, Jialun Zhu, Xuanbing Cheng

Keywords(s): Biomonitoring, Drug, Drug Delivery, Drug Development, Drug Discovery, Drug Resistance, Invasiveness Of Surgical Procedures, Microneedle array, non-invasive drug monitoring, Personalized Pharmacotherapy, Pharmaceutical Drug, Pharmacokinetics, Pharmacology, Prescription Drug, Therapeutic Drug Monitoring, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Medical Devices, Materials > Nanotechnology

Optimized Lentiviral Vector for Stem Cell Gene Therapy of Hemoglobinopathies

UCLA Case No. 2017-460 Summary UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. Background Sickle...

Published: 1/23/2024 | Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing

2018-438 A DNA CONSTRUCT FOR TARGETING THERAPEUTIC MOLECULES TO DISEASED TISSUE BY IMMUNE CELLS

INTRODUCTION:UCLA researchers in the Departments of Integrative Biology & Physiology and Pathology & Laboratory Medicine have developed a novel construct for targeting therapeutic biological molecules specifically to diseased tissue, using immune cells as a delivery system. BACKGROUND:Drug delivery is the process of administering a pharmaceutical...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Drug Delivery, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nucleic Acids

2021-092 FLOW REGULATION MECHANISM FOR COMPARTMENTALIZED LUNG VENTILATION

SUMMARY: UCLA researchers in the Department of Pulmonary and Clinical Care have developed a device capable of analyzing individual lungs in real-time to improve the quality of care for mechanically ventilated patients. BACKGROUND: Ventilators aid patients that have difficulty breathing by pressing positive air pressure into their lungs. Mechanical...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Angiogenesis Acute Lung Injury, Diagnostic Test, Drug Delivery, Instrumentation, Lung, Lung Pulmonology, Medical Device, Medical Imaging, Monitoring And Recording Systems, Respiratory & Pulmonary, Sensors, Software

Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Therapeutics > Infectious Diseases > COVID, Therapeutics > Respiratory And Pulmonary, Software & Algorithms > Programs

2020-426 PRODRUGS OF PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN

Researchers at UCLA have developed prodrugs of peripherally-acting cannabinoid (PRCBs) receptor agonists for chronic pain relief. BACKGROUND: Cannabinoids are becoming prevalent in chronic pain treatments even though current marketed cannabinoid compounds may cause psychotropic effects or central nervous system (CNS)-mediated side effects. A potential...

Published: 9/5/2023 | Inventor(s): Igor Spigelman, Alexander Spokoyny, Herbert Seltzman

Keywords(s): Cns, Drug Delivery, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > CNS and Neurology

2020-854 DUAL SELF-REGULATED DELIVERY OF INSULIN AND GLUCAGON BY A HYBRID PATCH

UCLA researchers have developed a novel hybrid microneedle patch that can deliver insulin and glucagon in a glucose-dependent manner. BACKGROUND: Type I diabetes (T1D) is an autoimmune disease in which pancreatic -cells are destroyed and there is a deficiency is insulin secretion. Type 2 diabetes (T2D) is a metabolic disorder resulting from insulin...

Published: 7/19/2023 | Inventor(s): Zhen Gu

Keywords(s): Drug Delivery, Medical Devices and Materials, Metabolic Diseases, Other Polymers, Polymers, Therapeutics & Vaccines

Category(s): Medical Devices, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Other Polymers, Therapeutics > Metabolism And Endocrinology

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