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2015-612 PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS VIA RING OPENING REACTIONS

INTRO SENTENCE: UCLA researchers in the Department of Bioengineering have developed a simple approach to modify polypeptides and proteins.BACKGROUND: Functionalized polypeptides and proteins are useful as drug delivery vehicles, bioconjugates and novel ligands. However, synthesis of complex polypeptides with defined post-polymerization modifications...

Published: 7/19/2023 | Inventor(s): Timothy Deming, Eric Gharakhanian

Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Drug Delivery, Peptide Base

Category(s): Chemical > Synthesis, Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Chemical > Industrial & Bulk Chemicals

2016-579 PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES

Preparation Of Functional Homocysteine Residues In Polypeptides And PeptidesSUMMARYUCLA researchers in the Department of Bioengineering and Department of Chemistry & Biochemistry have developed a novel method for efficient, chemoselective transformation of methionines in peptides and polypeptides into stable, functional homocysteine derivatives....

Published: 7/19/2023 | Inventor(s): Timothy Deming, Eric Gharakhanian

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base