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2021-189: NOVEL AND ROBUST COMBINATORY THERAPY FOR AORTIC ANEURYSMS

SUMMARY: Researchers from UCLA’s Department of Anesthesiology have developed an oral combinatory therapy that holds enormous implications in healthcare for the complete attenuation of aneurysm formation. BACKGROUND: Aortic aneurysms are abnormal protrusions in the major blood vessels from the heart to the rest of the body. These protrusions...

Published: 7/19/2023 | Inventor(s): Hua Linda Cai

Keywords(s):

Category(s): Therapeutics > Cardiovascular, Therapeutics > Hematology

2020-472 MIRNA-192-5P INHIBITORS AS NOVEL DRUGS TREATING AORTIC ANEURYSMS

UCLA researchers in the Department of Anesthesiology have developed novel inhibitors of miRNA-192-5P for the treatment of abdominal aortic aneurysms. BACKGROUND: Abdominal aortic aneurysm (AAA) occurs when the lower part of the major vessel that distributes blood to the body, the aorta, becomes weakened and enlarged. A weakened andenlarged aorta may...

Published: 7/19/2023 | Inventor(s): Hua Linda Cai

Keywords(s): Cardiovascular, Therapeutics & Vaccines

Category(s): Therapeutics > Cardiovascular

2019-728 NOVEL LIPID LOWERING, ANTI-ATHEROSCLEROSIS AND ANTI-OBESITY EFFECTS OF NETRIN-1

UCLA researchers in the Department of Anesthesiology have developed a novel and extremely robust lipid lowering, anti-atherosclerotic, and anti-obesity treatment with Netrin-1.BACKGROUND:Hyperlipidemia, an elevation of different forms of lipids in the bloodstream, is the most important risk factor for coronary heart disease, while causing many other...

Published: 9/5/2023 | Inventor(s): Hua Linda Cai

Keywords(s): Cardiovascular, Hematology, Therapeutics & Vaccines

Category(s): Therapeutics > Cardiovascular, Therapeutics > Hematology

2018-858 NETRIN-1 PEPTIDES FOR THE TREATMENT OF PULMONARY HYPERTENSION

INTRO SENTENCE:UCLA researchers in the Department of Anesthesiology & Perioperative Medicine have developed a treatment for pulmonary hypertension. BACKGROUND:Pulmonary hypertension (PH) is a devastating cardiovascular “cancer” with increased vascular resistance in the lung and chronic failure of the right heart. Common symptoms include:...

Published: 7/19/2023 | Inventor(s): Hua Linda Cai

Keywords(s): Cardiovascular, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Cardiovascular

2014-526 SMALL NETRIN-1 DERIVED PEPTIDES FOR CARDIOPROTECTION

Netrin-1 Compounds as Post-MI and Post-Angioplasty Therapeutics as well as for Treating Renal and CNS Reperfusion InjurySUMMARYUCLA researchers have invented a method of decreasing myocardial injury and infarct size through the intravenous administration of the netrin-1 or netrin-1-derived peptides during a cardiac event. These agents have powerful...

Published: 7/19/2023 | Inventor(s): Hua Linda Cai, Qiang Li

Keywords(s):

Category(s): Therapeutics, Therapeutics > Cardiovascular

2010-769 GROWTH FACTOR TREATMENT OF MYOCARDIAL INFARCTION

Growth Factor Treatment of Myocardial InfarctionSUMMARYUCLA investigators have invented a method of decreasing myocardial injury and infarct size through the intravenous administration of a growth hormone, netrin-1, during a cardiac event. This method confers powerful cardioprotective effects, and represents a novel and effective therapy for myocardial...

Published: 7/19/2023 | Inventor(s): Hua Linda Cai

Keywords(s):

Category(s): Therapeutics, Therapeutics > Cardiovascular