Search Results - inflammatory+diseases

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2013-741 Bioengineered Thymic Aggregates for Implantation

Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...

Published: 7/19/2023 | Inventor(s): Gay Crooks, Amelie Montel Hagen, Brile Chung

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy

2019-641 LATE TRANSITION METAL MEDIATED BASE PAIRS AND APPLICATIONS IN BIOTECHNOLOGY AND SYNTHESIS

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of metal-mediated base pair stabilization in vivo, with additional applications in the detection of small nucleic acids and regulation of transition metal catalysis. BACKGROUND:Recent studies of the interactions between transition metals and DNA have led...

Published: 7/19/2023 | Inventor(s): Hosea Nelson

Keywords(s): Catalysts, Chemical Manufacturing & Industrial/Bulk Chemicals, Inflammatory Diseases, Life Science Research Tools, Other, Therapeutics & Vaccines

Category(s): Chemical > Synthesis, Therapeutics > Inflammation And Inflammatory Diseases

2019-876 MAINTAINING FUNCTIONS AND PHENOTYPES OF CONNECTIVE TISSUE THROUGH NPAS2 SUPPRESSION

UCLA researchers in the Departments of Dentistry and Plastic Surgery have developed a novel suppressor of Npas2 for the regeneration of connective tissues.BACKGROUND:Open wounds of the skin and oral cavity are subject to infection and scarring if not properly closed. Patients may experience a variety of social consequences due to unclosed wounds of...

Published: 7/19/2023 | Inventor(s): Ichiro Nishimura, Akishige Hokugo, Hodaka Sasaki, Hiroko Okawa, Lixin Wang

Keywords(s): Dental, Inflammatory Diseases, Therapeutics & Vaccines

Category(s): Therapeutics > Dental, Therapeutics > Inflammation And Inflammatory Diseases

2019-958 SELECTIVE HDAC INHIBITORS

UCLA researchers in the Department of Chemistry and Biochemistry have synthesized a series of novel hydroxamic acids and derivatives as selective histone deacetylase (HDAC) inhibitors from simple starting materials.BACKGROUND:Histone deacetylase (HDAC) inhibitors are chemical compounds that regulates gene expression by inhibiting histone deacetylases....

Published: 7/19/2023 | Inventor(s): Michael Jung, Jonghoon Kim

Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Cns, Gene Editing Systems, Gene Therapy, Infectious Diseases, Inflammatory Diseases, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Infectious Diseases, Therapeutics > Gene Therapy And Editing, Therapeutics > Inflammation And Inflammatory Diseases, Chemical > Industrial & Bulk Chemicals

2019-731 EARLY PREDICTION OF PROGRESSION IN IDIOPATHIC PULMONARY FIBROSIS USING A SINGLE TIME POINT HRCT SCAN

UCLA researchers in the Department of Radiological Sciences have developed a novel single time point high-resolution computed tomography (HRCT) scan method for the early prediction of idiopathic pulmonary fibrosis disease progression.BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease that results in scarring of the lungs for an unknown...

Published: 7/19/2023 | Inventor(s): Hyun (Grace) Kim, Jonathan Gerald Goldin

Keywords(s): CT, Diagnostic Markers & Platforms, Inflammatory Diseases, Life Science Research Tools, Medical Imaging, Microscopy And Imaging

Category(s): Life Science Research Tools > Microscopy And Imaging, Medical Devices > Medical Imaging > CT, Therapeutics > Inflammation And Inflammatory Diseases

2019-468 PERIODONTAL MICROPATCH AND USES THEREOF

INTRODUCTION:UCLA researchers in the Departments of Bioengineering and Dentistry have developed a patch-based drug delivery system for dental applications.BACKGROUND:Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth, and it is estimated that 50% of the U.S. population suffers from some type of periodontal disease....

Published: 7/19/2023 | Inventor(s):

Keywords(s): Dental, Drug Delivery, Inflammatory Diseases, Medical Devices and Materials, Other Polymers

Category(s): Platforms > Drug Delivery > Other Polymers

2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration

Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...

Published: 7/19/2023 | Inventor(s): John Chute, Michael Jung, Emelyne Diers

Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology

Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

Wide-Field Imaging Of Birefringent Crystals In Synovial Fluid Using Lens-Free Polarized Microscopy For Crystal Arthropathy Diagnosis

UC Case No. 2016-848SUMMARYUCLA researchers in the Department of Electrical Engineering have developed a new diagnostic tool for arthropathic diseases, such as gout.BACKGROUNDConventionally, the diagnosis of gout relies on the observation of monosodium urate (MSU) crystals in synovial fluid aspirated from the joint of the patient and then examined under...

Published: 7/19/2023 | Inventor(s): Yibo Zhang, Aydogan Ozcan, Seung Yoon Lee

Keywords(s): Autoimmune, Inflammatory Diseases, Medical Imaging

Category(s): Therapeutics > Autoimmune, Medical Devices > Medical Imaging, Therapeutics > Inflammation And Inflammatory Diseases

2018-388 METABOLIC REQUIREMENTS FOR ALTERNATIVE MACROPHAGE ACTIVATION

Metabolic Requirements for Alternative Macrophage ActivationSUMMARYUCLA researchers in the Department of Molecular and Medical Pharmacology have discovered that Coenzyme A is a targetable requirement for anti-inflammatory macrophage differentiation.BACKGROUNDA dysregulated immune response is a hallmark of many disease phenotypes. For instance, cancer...

Published: 7/19/2023 | Inventor(s): Steven Bensinger, Ajit Divakaruni, Anne Murphy, Wei Yuan Hsieh

Keywords(s): Autoimmune, Drug Delivery, Infectious Diseases, Inflammatory Diseases, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

Antitumor Activity Of Sd-101 Alone Or In Combination With A-Pd-1 Therapy In Tumors Resistant To Anti-Pd-1

SummaryUCLA researchers in the Department of Medicine have developed a novel antitumor treatment that works alone or in combination with anit-PD-1 therapy to target interferon signaling-deficient tumors or tumors with alterations in the antigen presentation machinery, that are resistant to anti-PD-1 therapy.BackgroundProgrammed cell death protein 1...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Immunotherapy, Inflammatory Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases

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