Search Results - irvin+s.y.+chen

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2018-856 AN APPROACH FOR TARGETED CONDITIONING FOR T CELL TRANSPLANTS

UCLA researchers in the Departments of Microbiology, Immunology, and Molecular Genetics have identified a pre-conditioning reagent for Adoptive Cell Transfer (ACT). The identified reagent specifically ablates T-cells making room for infused cells to engraft and has negligible toxicities compared to traditional conditioning therapies that affect all...

Published: 9/5/2023 | Inventor(s): Irvin S.Y. Chen, Sanggu Kim, Masakazu Kamata, Gajendra Suryawanshi, Robert Donahue

Keywords(s): Immunotherapy, Therapeutics & Vaccines

Category(s): Therapeutics > Immunology And Immunotherapy

2015-671 Underground Shafts for Hydrogen Storage

SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...

Published: 7/19/2023 | Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove

Keywords(s): Energy & Water

Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage

2018-749 A METHOD TO DISTINGUISH DIFFERENT RETROVIRAL VECTORS DURING INTEGRATION SITE ANALYSIS

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel gene therapy vector identifying method, capable of screening toxicities of combination therapies.TITLE: A Method to Distinguish Different Retroviral Vectors During Integration Site Analysis BACKGROUND: Many diseases originate from defective...

Published: 7/19/2023 | Inventor(s): Irvin S.Y. Chen, Gajendra Suryawanshi, Sanggu Kim

Keywords(s): Gene Editing Systems, Gene Therapy, Life Science Research Tools, Plasmids / Vectors, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Therapeutics, Therapeutics > Gene Therapy And Editing

2016-255 Method to Enrich for Cells Transduced with Chimeric Antigen Receptors for Gene Therapy (2016-051 rolled in)

Method to Enrich for Cells Transduced with Chimeric Antigen ReceptorsSUMMARYResearchers at UCLA have developed a method to expand chimeric antigen receptor-transduced T cells for use in immunotherapies.BACKGROUNDChimeric Antigen Receptors (CAR) T cells are promising therapeutics for the treatment of cancer and are also being considered for the treatment...

Published: 2/14/2024 | Inventor(s): Otto Yang, Jerome Zack, Scott Kitchen, Ayub Ali, Hwee Ng, Irvin S.Y. Chen

Keywords(s): Oncology Immunotherapy, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy

2010-709 VIRAL EXPRESSION VECTOR Targeting HIV-1

SummaryUCLA researchers from the Department of Microbiology, Immunology, & Molecular Genetics have developed a viral expression vector that combines two reagents effective against HIV-1 infection.BackgroundHighly active antiretroviral therapy (HAART) has decreased the morbidity and mortality of human immune deficiency virus (HIV) in all parts of...

Published: 7/19/2023 | Inventor(s): Irvin S.Y. Chen, Dong Sung An, Geoff Symonds, Louis Breton, Michelle Millington, Maureen Boyd

Keywords(s): Gene Editing Systems, Gene Therapy, Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Infectious Diseases, Therapeutics > Gene Therapy And Editing

2000-128 TARGETING LENTIVIRAL VECTORS TO SPECIFIC CELLS AND TISSUES

SummaryResearchers in the UCLA Departments of Medicine and Microbiology, Immunology and Molecular Genetics have developed retroviral vectors pseudotyped with a modified Sinbus virus envelope that exhibit reduced tropism and can be used for the targeted transduction of heterologous genes into cells.BackgroundThere have been numerous attempts to develop...

Published: 7/19/2023 | Inventor(s): Irvin S.Y. Chen, Kouki Morizono

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing