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1-Micron Frequency Comb OCT System (Case No. 2023-036)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a new optical coherence tomography system for clinical imaging applications. Background: Optical coherence tomography (OCT) is a non-invasive imaging technique that is used in many clinical settings. OCT is used in ophthalmology to visualize layers...

Published: 3/20/2024 | Inventor(s): Chee Wei Wong, Tristan Melton, James McMillan

Keywords(s):

Category(s): Electrical, Electrical > Imaging, Electrical > Electronics & Semiconductors, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Animal Imaging, Mechanical, Mechanical > Instrumentation

Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)

UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...

Published: 2/26/2024 | Inventor(s): Sherie Morrison, John Timmerman, Kham (Ryan) Trinh

Keywords(s): Antibody Delivery Platforms, Drug Delivery, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Life Science Research Tools, Therapeutics > Immunology And Immunotherapy

Antitumor activity of NKTR-214 alone or in combination with anti-PD-1 therapy in tumors resistant to anti-PD-1 (UCLA Case No. 2019-254)

UCLA researchers have discovered a therapy for anti-PD-1 resistant tumors in colon carcinoma patients. A small molecule therapeutic alone or in combination with immune-checkpoint blockade (ICB) therapy exhibits tumor remission even in sublines with mutated signalling pathways that have rendered them ICB resistant. BACKGROUND: Immunotherapy, the...

Published: 2/15/2024 | Inventor(s): Antoni Ribas

Keywords(s): Colon carcinoma, Immune checkpoint blockade, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), PD-1, PD-L1, Resistant tumors, Signaling pathways, Small molecule therapeutics, Tumor

Category(s): Life Science Research Tools, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)

A Programming Language to Execute Biological Experiments (Command Line Biology/Biowrapper) (Case No. 2024-049)

Intro Sentence: UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a programming language to automate biological experiments. Background: Manual labor is a common bottleneck in biological sciences, with automation technology still being unobtainable and impractical for most scientists in biomedical research....

Published: 4/4/2024 | Inventor(s): Robert Damoiseaux, Michael Mellody, Ronan Bennett, Alejandro Huerta, Rutu Shah

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, artificial-intelligent materials, Automation, generative artificial intelligence, Machine Learning, machine learning modeling, Medical artificial intelligence (AI), Programmable Logic Device

Category(s): Software & Algorithms, Software & Algorithms > Data Analytics, Software & Algorithms > Programs, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Research Methods

Lip Protector for Preventing Oral Injuries During Intubation (Case No. 2018-171)

Summary: UCLA researchers in the David Geffen School of Medicine have designed a novel lip and tooth protector for intubation processes. Background: General anesthesia usually requires an artificial airway or breathing tube to be placed in a patient’s mouth or throat in order to help with proper breathing during medical procedure. Even with...

Published: 4/1/2024 | Inventor(s): Negar Motayagheni

Keywords(s): Hospital Systems And Devices, Life Science Research Tools, Medical Devices and Materials, Surgical Tools

Category(s): Life Science Research Tools, Medical Devices, Medical Devices > Surgical Tools

Light-Field Tomographic Fluorescence Lifetime Imaging Microscopy (Case No. 2023-130)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel fluorescence lifetime imaging microscopy technique which enables fast 3D imaging using low dimensional detectors. Background: Fluorescence lifetime imaging microscopy, or FLIM, measures the fluorescence lifetime of probes embedded in tissue samples which enables...

Published: 1/22/2024 | Inventor(s): Liang Gao, Yayao Ma

Keywords(s): FLIM, fluorescence lifetime, fluorescence microscopy, organoid imaging, pixel fill factor, single-photon avalanche detector, SPAD array, spectral FLIM, three dimensional imaging, time-correlated single photon counting mode, z stack

Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Optics & Photonics, Optics & Photonics > Microscopy

Label-Free Optical Mapping for Large-Area Biomechanical Dynamics of Multicellular Systems (Case No. 2023-290)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel label-free optical mapping method for profiling real-time biomechanical dynamics over larger areas with high spatiotemporal resolution. Background: Mapping biomechanical dynamics often involves the use of various advanced technologies to measure...

Published: 12/20/2023 | Inventor(s): Pei Yu Chiou, Yen-Ju Lin

Keywords(s): bioimaging, Biomechanics, cell imaging, Confocal Microscopy, dye, Fluorescence Microscope, labeling, Microscopy, Microscopy And Imaging, resolution, traction force microscopy

Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Cell Counting And Imaging, Medical Devices, Medical Devices > Medical Imaging, Platforms, Platforms > Diagnostic Platform Technologies

Swabseq Agnostic Diagnostic Platform (Case No. 2023-293)

Summary: UCLA researchers in the Departments of Computer Science and Anatomic Pathology have developed an untargeted NGS diagnostic tool capable of detecting all known and emerging respiratory RNA viruses in a single test, enhancing our capacity to rapidly address public health crises through improved diagnostics. Background: Most clinical diagnostic...

Published: 11/29/2023 | Inventor(s): Eleazar Eskin, Valerie Arboleda

Keywords(s): agnostic detection, Bioinformatics, bioinformatics pipeline, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Test, DNA Sequencing, Medical diagnostics, metagenomic diagnostic platform, meta-genomics, next generation sequencing (NGS), Pathogen, Pathogenesis, Sequencing

Category(s): Platforms, Platforms > Diagnostic Platform Technologies, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Bioinformatics

Virtual Impactor-Based Label-Free Bio-Aerosol Detection Using Holography and Deep Learning (Case No. 2023-037)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a virtual aerosol detection method that combines imaging and deep learning to sense and classify bio-aerosols without any external labeling or post processing steps. Background: Bio-aerosol detection and classification is pivotal to understanding and...

Published: 2/27/2024 | Inventor(s): Aydogan Ozcan, Yi Luo, Tairan Liu

Keywords(s): air quality measurement, Artificial Neural Network, bioterrorism, computational imaging, Deep learning-based sensing, Digital Electronics, Digital Holography, Digital Signal Processing, Imaging, label-free imaging, label-free sensing, Mass Spec, pollen detection, Sensors, virtual impactors

Category(s): Electrical, Electrical > Sensors, Electrical > Imaging, Life Science Research Tools, Life Science Research Tools > Mass Spectrometry

Wireless and Batteryless Localization and Physiological Motion Detection System (Case No. 2023-046)

Summary: UCLA researchers in the Electrical and Computer Engineering Department have developed a battery-free localization system equipped with wireless energy harvesting feature, allowing precise localization in gastrointestinal disease detection and treatment. Background: The evolution of wireless capsule endoscopy (WCE) has emerged as a convenient...

Published: 3/7/2024 | Inventor(s): Aydin Babakhani, Arkaprova Ray, Iman Habibagahi

Keywords(s): battery-less, biomedical sensors, capsule endoscope, Energy Harvesting, gastrointestinal (GI) tract diseases, implantable sensors, localization, localization accuracy, motion detection, point-of-care, wireless capsule endoscopy, wireless energy harvesting

Category(s): Electrical, Electrical > Sensors, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Medical Devices, Medical Devices > Medical Imaging, Platforms, Platforms > Diagnostic Platform Technologies

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