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Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)

UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...

Published: 2/26/2024 | Inventor(s): Sherie Morrison, John Timmerman, Kham (Ryan) Trinh

Keywords(s): Antibody Delivery Platforms, Drug Delivery, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Life Science Research Tools, Therapeutics > Immunology And Immunotherapy

Lip Protector for Preventing Oral Injuries During Intubation (Case No. 2018-171)

Summary: UCLA researchers in the David Geffen School of Medicine have designed a novel lip and tooth protector for intubation processes. Background: General anesthesia usually requires an artificial airway or breathing tube to be placed in a patient’s mouth or throat in order to help with proper breathing during medical procedure. Even with...

Published: 4/1/2024 | Inventor(s): Negar Motayagheni

Keywords(s): Hospital Systems And Devices, Life Science Research Tools, Medical Devices and Materials, Surgical Tools

Category(s): Life Science Research Tools, Medical Devices, Medical Devices > Surgical Tools

Antibody-Drug Conjugates Targeting Stem Cell-Derived Cancer Cells and Tumor Stroma (UCLA Case No. 2020-790)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a versatile antibody-drug conjugate platform utilizing a novel monoclonal antibody that is highly specific at targeting cancer cells and rapidly internalized by those cells for an effective anti-tumor response. BACKGROUND: For decades, an absolute majority of...

Published: 2/13/2024 | Inventor(s): Robert Damoiseaux, Hans Ulmert, Hans David Ulmert, Norbert Peekhaus, Liqun Mao, Claire Storey

Keywords(s): Antibody, diagnostic radionuclides, Imaging, Life Science Research Tools, Medical Imaging, Mesenchymal Stem Cell Derived Cancer Cells, Oncology, PET, therapeutic radionuclides, Tumor microenvironment, Tumor Stroma

Category(s): Medical Devices > Medical Imaging > PET

2023-123 Systems for Covertly Creating Adverse Health Effects in Subjects

Summary: UCLA researchers in the Division of Physics and Astronomy have developed a less-than-lethal method for covertly creating adverse health effects in human subjects using particular waveforms. Background: Several less-than-lethal techniques for altering or influencing the behavior of target subjects without physical contact have been developed....

Published: 8/21/2023 | Inventor(s):

Keywords(s): electromagnetic, Hardware, Instrumentation, Life Science Research Tools, Security and defense, security imaging

Category(s): Life Science Research Tools > Animal Models, Electrical > Sensors, Electrical > Imaging, Medical Devices > Neural Stimulation

2017-730 Reducing Computational Complexity of Training Algorithms for Artificial Neural Networks

Summary: Researchers at UCLA have developed a novel mathematical theorem to revolutionize the training of large-scale artificial neural networks (ANN). Background: Artificial neural networks (ANNs) have gained popularity in recent years due to their exceptional performance and applicability to a wide array of machine learning applications. ANNs digitally...

Published: 7/19/2023 | Inventor(s): Khalid Youssef, Louis-Serge Bouchard

Keywords(s): Advanced Computing / AI, Life Science Research Tools, Medical Imaging, Software, Software & Algorithms

Category(s): Life Science Research Tools, Software & Algorithms, Medical Devices > Medical Imaging, Electrical > Quantum Computing, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Programs

2022-214 Machine-Learning-Based Automatic Analysis of Electrochemical Characterizations

SUMMARY: UCLA researchers in the Department of Chemistry and Biochemistry have developed a machine-learning based algorithm that identifies reaction mechanisms from cyclic voltammetry data and offers accurate interpretations of complex electrochemical data. BACKGROUND: Electrochemistry is a readily accessible and valuable tool for researchers to...

Published: 7/19/2023 | Inventor(s): Chong Liu, Quanquan Gu, Benjamin Hoar, Weitong Zhang

Keywords(s): Algorithm, Instrumentation & Analysis, Life Science Research Tools, Machine Learning, Software & Algorithms

Category(s): Life Science Research Tools > Research Methods, Electrical > Instrumentation, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Programs

2019-346 Low-Cost And Portable UV Holographic Microscope For High-Contrast Protein Crystal Imaging

Summary: UCLA researchers in the Department of Electrical Engineering have developed an on-chip UV holographic imaging microscope that offers a low-cost, portable, and robust technique to image and distinguish protein crystals from salt crystals. Background: Dual-mode microscopes composed of bright-field and ultraviolet (UV) induced fluorescence...

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Aniruddha Ray, Mustafa Daloglu

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Medical Devices and Materials, Medical Imaging, Microscopy And Imaging, Monitoring And Recording Systems, Other

Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Diagnostic Markers, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies

2022-140 Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue Using Deep Learning

SUMMARY: UCLA researchers in the Departments of Bioengineering and Electrical and Computer Engineering have developed a deep learning-based algorithm that can detect and quantify the breast cancer marker human epidermal growth factor receptor 2 (HER2) in microscopic images without the need for time-consuming immunohistochemical staining (IHC). BACKGROUND:...

Published: 4/9/2024 | Inventor(s): Aydogan Ozcan, Yair Rivenson, Bijie Bai, Hongda Wang

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Biomarker, Bladder Cancer, Breast Cancer, Cancer, Cancer Immunotherapy, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Test, Fluorescence, Fluorescent Labelling, HER2/Neu, Histology, Immune System, Immunohistochemistry, Life Science Research Tools, Machine Learning, Optics, Research Methods, Unsupervised Learning

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers, Diagnostic Markers > Immunology, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence, Software & Algorithms > Artificial Intelligence & Machine Learning, Optics & Photonics

2020-487 Early-Detection and Classification of Live Bacteria Using Time-Lapse Coherent Imaging and Deep Learning

Summary: Researchers from UCLA’s Electrical and Computer Engineering and Bioengineering Departments have invented a novel automated system that quickly detects and classifies colonies of live bacteria in water by using deep neural networks to analyze holographic images. Background: Early identification of pathogenic bacteria in food, water,...

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Yair Rivenson, Hongda Wang, Hatice Ceylan Koydemir, Yunzhe Qiu

Keywords(s): Diagnostic Platform Technologies (E.G. Microfluidics), Hospital Systems And Devices, Imaging, Instrumentation & Analysis, Life Science Research Tools, Microscopy And Imaging

Category(s): Electrical > Instrumentation, Electrical > Imaging, Software & Algorithms, Diagnostic Markers, Software & Algorithms > Artificial Intelligence & Machine Learning

2016-219-3 SYSTEM AND METHOD FOR OPTICAL TRANSIENT LIQUID MOLDING OF MICROPARTICLES AND USES FOR THE SAME

SUMMARY: The Di Carlo group at UCLA has invented a microparticle that enables analysis of adherent cells via flow cytometry with high throughput. BACKGROUND: Traditional flow cytometry is a fluorescence-based technique used to characterize cells on a molecular level usually suspended in a fluid. However, many cells are inherently attached to matrix...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Chueh-Yu Wu

Keywords(s): Cell Counting/Imaging, Cytometry, Diagnostic Platform Technologies (E.G. Microfluidics), Flow Cytometry, Life Science Research Tools, Microfluidics, Microfluidics And Mem's, Targets And Assays

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

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