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Cell Type Scanner (UCLA Case No. 2021-115)

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel technology for spatial cell-type mapping in 2D and 3D tissue samples. BACKGROUND: Cell type mapping has become an integral component for many biomedical research studies and diagnostic technologies. However, a major challenge in single cell data is accurately...

Published: 4/8/2024 | Inventor(s): Roy Wollman

Keywords(s): 3D tissue imaging, cell mapping, Principal component analysis, RNA imaging, single cell analysis, Single cell data

Category(s): Life Science Research Tools > Research Methods, Software & Algorithms > Data Analytics

A Programming Language to Execute Biological Experiments (Command Line Biology/Biowrapper) (Case No. 2024-049)

Intro Sentence: UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a programming language to automate biological experiments. Background: Manual labor is a common bottleneck in biological sciences, with automation technology still being unobtainable and impractical for most scientists in biomedical research....

Published: 4/4/2024 | Inventor(s): Robert Damoiseaux, Michael Mellody, Ronan Bennett, Alejandro Huerta, Rutu Shah

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, artificial-intelligent materials, Automation, generative artificial intelligence, Machine Learning, machine learning modeling, Medical artificial intelligence (AI), Programmable Logic Device

Category(s): Software & Algorithms, Software & Algorithms > Data Analytics, Software & Algorithms > Programs, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Research Methods

Swabseq Agnostic Diagnostic Platform (Case No. 2023-293)

Summary: UCLA researchers in the Departments of Computer Science and Anatomic Pathology have developed an untargeted NGS diagnostic tool capable of detecting all known and emerging respiratory RNA viruses in a single test, enhancing our capacity to rapidly address public health crises through improved diagnostics. Background: Most clinical diagnostic...

Published: 11/29/2023 | Inventor(s): Eleazar Eskin, Valerie Arboleda

Keywords(s): agnostic detection, Bioinformatics, bioinformatics pipeline, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Test, DNA Sequencing, Medical diagnostics, metagenomic diagnostic platform, meta-genomics, next generation sequencing (NGS), Pathogen, Pathogenesis, Sequencing

Category(s): Platforms, Platforms > Diagnostic Platform Technologies, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Bioinformatics

Core-Shell Hydrogel Particles With Tunable Porosity for Digital Nucleic Acid Assays (Case No. 2023-058)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel method to perform ultra-high sensitivity, low-cost nucleic acid amplification assays utilizing porous microdroplets. Background: Nucleic acid concentration measurement is essential in biological research and diagnostics. The 2020 pandemic underscored the importance...

Published: 8/30/2023 | Inventor(s): Dino Di Carlo, Michael Thomas Alesse Bogumil

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Flow Cytometry, Medical diagnostics

Category(s): Diagnostic Markers > Cancer, Diagnostic Markers > Targets And Assays, Chemical > Emulsions, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies

Stain-Free, Rapid, and Quantitative Viral Plaque Assay Using Deep Learning and Holography (Case No. 2022-326)

Intro Sentence: UCLA researchers in the Department of Electrical and Computer Engineering have developed a rapid and stain-free quantitative assay using lens-free holography and deep learning to efficiently and cost-effectively determine the presence of viral plaque-forming units (PFUs) in samples. Background: A broad range of viruses have caused...

Published: 3/7/2024 | Inventor(s): Aydogan Ozcan, Yuzhu Li, Tairan Liu

Keywords(s): Antiviral Drug, Artifical Intelligence (Machine Learning, Data Mining), Assay, Bioassay, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Digital Holography, Electrical, Electrical Brain Stimulation, Electrical Breakdown, Electrical Engineering, Electrical Impedance, Electrical Load, Electrical Load Equation Of State, Electrical Resistance And Conductance, Electrical Resistivity And Conductivity, Holography, Immunoassay, Immunoassay Sense (Molecular Biology), Lentivirus Viral Vector, Machine Learning, Machine Learning Autonomous Car Gradient Descent, Machine Learning Pain Management, Machine Learning Particulates Global Climate Model, Network Analysis (Electrical Circuits), Perceptual Learning, Plasmid Trabecular Meshwork Aqueous Humour Viral Vector, Targets And Assays, Transcutaneous Electrical Nerve Stimulation, Transfection Viral Vector, Unsupervised Learning , Viability Assay, Viral Delivery Systems, Viral Envelope, Viral Load

Category(s): Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Software & Algorithms > Artificial Intelligence & Machine Learning

A Behavioral Method of Cognitive Assessment and Training, and Cognitive Decline Remediation (UCLA Case No. 2023-061)

Summary: UCLA researchers in the Department of Psychology have developed a simple and fast computerized test to assess cognition (and detect possible cognitive impairment), and a novel game-like method to produce cognitive and memory improvements. Background: In the United States, approximately two out of three adults aged 70 and over experience...

Published: 11/7/2023 | Inventor(s): Ladan Shams

Keywords(s): cognitive function, Cognitive Therapy, drift diffusion model, Memory, Mild Cognitive Impairment, multisensory integration, Neurocognitive, Neuropsychological Test, Perceptual Learning, perceptual processing, Psychiatry / Mental Health, Psychology, Psychotherapy, Sensory System, Software, Software & Algorithms, Software Development Tools

Category(s): Software & Algorithms, Life Science Research Tools, Life Science Research Tools > Research Methods

2023-102 A Dynamic Cholesteric Liquid Crystal for Organoid, Spheroid, 3D Cell Aggregate Manufacturing

Summary: UCLA and University of Connecticut researchers have engineered a novel liquid-crystal-based biomaterial with a simple fabrication process for organoid, spheroid and 3D cell aggregate manufacturing that enables rapid cell growth. Background: The current waiting list for people who need a lifesaving organ transplant is over 100,000 cases...

Published: 7/19/2023 | Inventor(s): Paul Weiss, Amir Nasajpour, Ali Tamayol, Mohamadmahdi Samandari

Keywords(s): 3D biofabrication, 3D Printing, Biocompatibility, biocompatible, Biomaterial 3D Printing, biomedical implantation, Cell and tissue culture, Cell Culture, cell-extracellular matrix (ECM), cellular aggregates, Cellular agriculture, Cholesterol, cholesteryl ester liquid crystals (CLCs), Cultured meat, Electrode 3D Printing, liquid crystal, liquid crystal nanofibers, mesogens, Organ Transplant, organogenesis, scaffolds, self-assemble, Stem Cells / Regenerative Medicine, Tissue Engineering

Category(s): Chemical, Chemical > Polymers, Materials, Materials > Functional Materials, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Medical Devices, Medical Devices > Surgical Tools, Therapeutics, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2023-021 A Ferrobotic Swarm Technology for Accessible, Adaptable, and Automated Testing

Summary: UCLA Researchers in the Department of Electrical and Computer Engineering have developed an automated, algorithm-driven nucleic acid amplification test (NAAT) method that is easy to manufacture, distribute, and yields accurate results with reduced demand of testing reagents. Background: Major epidemics over the last two decades have emerged...

Published: 8/8/2023 | Inventor(s): Dino Di Carlo, Sam Emaminejad, Haisong Lin, Wenzhuo Yu, Kiarash AmirMozafariSabet

Keywords(s): Algorithm, algorithm-based testing, automated testing, Automation, Cell Counting/Imaging, COVID-19, Ferrofluid, ferrorobotics, high throughput testing, Nanotechnology, nucleic acid amplification test (NAAT), Nucleic Acid Platform Systems, Nucleic Acids, polymerase chain reaction (PCR), pooling, Software & Algorithms, viral testing

Category(s): Software & Algorithms, Life Science Research Tools, Life Science Research Tools > Research Methods, Electrical > Electronics & Semiconductors, Diagnostic Markers, Life Science Research Tools > Cell Counting And Imaging, Platforms > Diagnostic Platform Technologies

2022-214 Machine-Learning-Based Automatic Analysis of Electrochemical Characterizations

SUMMARY: UCLA researchers in the Department of Chemistry and Biochemistry have developed a machine-learning based algorithm that identifies reaction mechanisms from cyclic voltammetry data and offers accurate interpretations of complex electrochemical data. BACKGROUND: Electrochemistry is a readily accessible and valuable tool for researchers to...

Published: 7/19/2023 | Inventor(s): Chong Liu, Quanquan Gu, Benjamin Hoar, Weitong Zhang

Keywords(s): Algorithm, Instrumentation & Analysis, Life Science Research Tools, Machine Learning, Software & Algorithms

Category(s): Life Science Research Tools > Research Methods, Electrical > Instrumentation, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Programs

2022-174 Diffractive All-Optical Computing for Quantitative Phase Imaging

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an all-optical quantitative phase imaging (QPI) method that could replace traditionally burdensome and power-inefficient computational image processing networks and improve current limitations in biological imaging. Background: The application of...

Published: 2/16/2024 | Inventor(s): Aydogan Ozcan, Deniz Mengu

Keywords(s): Diffraction Tomography, Digital Holography, Digital immunohistology, Electron Holography, Fluorescence Microscope, Histology, Holography, Immunohistochemistry, Immunology, Lighting and Illumination, on-chip microscopy, Optics, Photonics, quantitative phase imaging (QPI)

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Microscopy And Imaging, Electrical, Electrical > Sensors, Electrical > Signal Processing, Electrical > Imaging, Medical Devices > Medical Imaging, Optics & Photonics, Optics & Photonics > Microscopy, Optics & Photonics > Holography

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