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2020-854 DUAL SELF-REGULATED DELIVERY OF INSULIN AND GLUCAGON BY A HYBRID PATCH

UCLA researchers have developed a novel hybrid microneedle patch that can deliver insulin and glucagon in a glucose-dependent manner. BACKGROUND: Type I diabetes (T1D) is an autoimmune disease in which pancreatic -cells are destroyed and there is a deficiency is insulin secretion. Type 2 diabetes (T2D) is a metabolic disorder resulting from insulin...

Published: 7/19/2023 | Inventor(s): Zhen Gu

Keywords(s): Drug Delivery, Medical Devices and Materials, Metabolic Diseases, Other Polymers, Polymers, Therapeutics & Vaccines

Category(s): Medical Devices, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Other Polymers, Therapeutics > Metabolism And Endocrinology

2013-741 Bioengineered Thymic Aggregates for Implantation

Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...

Published: 7/19/2023 | Inventor(s): Gay Crooks, Amelie Montel Hagen, Brile Chung

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy

Photocurable Poly(ethylene Glycol) as a Bioink for the Inkjet 3D Pharming of Hydrophobic Drugs

UC Case No. 2018-197SUMMARY: UCLA researchers in the Department of Bioengineering have developed a novel inkjet 3D pharming technique that is fast, customizable, and compatible with hydrophobic drugs. BACKGROUND: 3D pharming is an innovative technique that combines 3D printing and 2D material deposition to create personalized drug tablets that...

Published: 7/19/2023 | Inventor(s): Benjamin Wu, Chase Linsley

Keywords(s): Drug Delivery, Other Polymers, PEG

Category(s): Platforms > Drug Delivery > Other Polymers, Platforms > Drug Delivery > PEG

2019-238 MIXTURES OF SYNTHETIC COPOLYPEPTIDE HYDROGELS

UCLA researchers in the Department of Bioengineering have developed a novel polypeptide-based hydrogel mixture that offers a large degree of biocompatibility and biodegradability while also offering the ability to tune mechanical properties. Specifically, these compositions allow for high hydrogel stiffness at low polymer concentrations, while retaining...

Published: 7/19/2023 | Inventor(s): Timothy Deming

Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Drug Delivery, Other Polymers

Category(s): Platforms > Drug Delivery > Other Polymers, Chemical > Industrial & Bulk Chemicals

2019-468 PERIODONTAL MICROPATCH AND USES THEREOF

INTRODUCTION:UCLA researchers in the Departments of Bioengineering and Dentistry have developed a patch-based drug delivery system for dental applications.BACKGROUND:Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth, and it is estimated that 50% of the U.S. population suffers from some type of periodontal disease....

Published: 7/19/2023 | Inventor(s):

Keywords(s): Dental, Drug Delivery, Inflammatory Diseases, Medical Devices and Materials, Other Polymers

Category(s): Platforms > Drug Delivery > Other Polymers

2015-798 NONCRUSHABLE PILL FORMULATIONS

SUMMARY: UCLA Researchers in the Department of Chemistry have developed a drug formulation for opioids capable of deterring drug abuse. BACKGROUND: It is estimated that more than 115 Americans a day, died to opioid overdose in 2016. The currently projected estimate is that this number will increase to over 150 Americans a day fatally overdosing on opioids....

Published: 7/19/2023 | Inventor(s): Heather Maynard, Erhan Bat

Keywords(s): Drug Delivery, Nanoparticles, Other Polymers

Category(s): Platforms > Drug Delivery > Other Polymers, Platforms > Drug Delivery > Nanoparticles

Silicon Nanovolcanos for Gene Delivery with High Efficiency and Cell Viability

INTRO SENTENCE: UCLA researchers in the department of Chemistry and Biochemistry have developed a novel technique of intracellular cargo delivery using nanovolcanos with high efficiency and cell viability.BACKGROUND: Intracellular cargo delivery facilitates cellular reprogramming and development of next generation gene and cellular therapies....

Published: 7/19/2023 | Inventor(s): Paul Weiss, Hsian-Rong Tseng, Qing Yang, Xiaobin Xu, Shuang Hou, Steven Jonas

Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Drug Delivery, Gene Therapy, Other Polymers

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Other Polymers, Chemical > Industrial & Bulk Chemicals, Therapeutics > Gene Therapy And Editing

2014-554 TREHALOSE HYDROGELS FOR STABILIZATION AND DELIVERY OF PROTEINS

Trehalose Hydrogels For Stabilization And Delivery Of ProteinsCase No. 2014-554-0SUMMARYUCLA researchers in the Department of Chemistry and Biochemistry have developed a novel trehalose hydrogel to help stabilize proteins for drug delivery.BACKGROUNDProteins are at the core of biologic drugs and are used to treat a range of disease states including...

Published: 7/19/2023 | Inventor(s): Heather Maynard

Keywords(s): Drug Delivery, Medical Devices and Materials, Other Polymers, Therapeutics & Vaccines

Category(s): Medical Devices, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Other Polymers

2012-340 A Novel Basic Fibroblast Growth Factor Conjugate for Broad Therapeutic Application

A Novel Basic Fibroblast Growth Factor Conjugate for Broad Therapeutic ApplicationSUMMARYUCLA scientists have developed a novel polymer conjugate of basic fibroblast growth factor (bFGF) for use in commercial and possibly clinical applications. This is the first bFGF conjugate to enhance bioactivity and stability under environmental stressors. BACKGROUNDBasic...

Published: 7/19/2023 | Inventor(s): Heather Maynard, Thi Nguyen

Keywords(s): Catalysts, Dermatology, Other Polymers, Therapeutics & Vaccines

Category(s): Chemical > Synthesis, Therapeutics, Therapeutics > Dermatology, Platforms > Drug Delivery > Other Polymers

2016-946 Synthesis of Graphene Nanoribbons from Monomeric Molecular Precursors Bearing Reactive Alkyne Units

Synthesis Of Graphene Nanoribbons From Monomeric Molecular Precursors Bearing Reactive Alkyne UnitsSUMMARYResearchers in the Department of Chemistry and Biochemistry have developed a novel graphene nanoribbon synthesis, which have numerous applications in electronic devices.BACKGROUNDGraphene nanoribbons (GNRs), narrow strips of graphene <10 nm in...

Published: 7/19/2023 | Inventor(s): Yves Rubin

Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Electronics & Semiconductors, Nanoparticles, Other Polymers

Category(s): Electrical > Electronics & Semiconductors, Platforms > Drug Delivery > Nanoparticles, Chemical > Industrial & Bulk Chemicals, Platforms > Drug Delivery > Other Polymers

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