Search Results - other+reagents

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2020-371 WNT-B-CATENIN SIGNALING PATHWAY INHIBITORS

UCLA researchers from the Department of Pediatrics have uncovered a novel inhibitor to the Wnt/β-catenin signaling pathway.BACKGROUND:Airways in the throat play a vital role in host defense to protect mammals from airborne pathogens. This protective effect is accomplished by a specialized type of epithelium, the mucocillary epithelium, that comes...

Published: 7/19/2023 | Inventor(s): Brigitte Gomperts

Keywords(s): Infectious Diseases, Life Science Research Tools, Other Reagents, Therapeutics & Vaccines

Category(s): Life Science Research Tools > Other Reagents, Therapeutics > Infectious Diseases

2018-022 SMALL MOLECULE MODULATORS THAT MEDIATE PINK1 AND PARKIN TRAFFICKING IN MITOCHONDRIA

UCLA researchers have developed two novel small molecule probes, MB-10 and DECA, that attenuate PINK1 and Parkin trafficking in mitochondrial in human cells that provide a new approach to elucidate the mechanisms of mitophagy.BACKGROUND:Mitophagy is an important pathway that selectively degrades dysfunctional mitochondria to keep the cell healthy. Neurodegenerative...

Published: 7/19/2023 | Inventor(s): Carla Koehler

Keywords(s): Life Science Research Tools, Other Reagents

Category(s): Life Science Research Tools > Other Reagents

2020-148 METHODS FOR PRODUCING D-TRYPTOPHAN AND SUBSTITUTE D-TRYPTOPHANS

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel biochemical synthesis process to produce D-Tryptophan at high yield and 98% enantiomeric excess with peptide synthetase IvoA from recombinant yeast.BACKGROUND:D-tryptophans are important building blocks of many peptide-based pharmaceuticals. The common...

Published: 7/19/2023 | Inventor(s): Yi Tang, Yang Hai

Keywords(s): Catalysts, Chemical Manufacturing & Industrial/Bulk Chemicals, Life Science Research Tools, Other Reagents

Category(s): Life Science Research Tools > Other Reagents, Chemical > Synthesis, Chemical > Industrial & Bulk Chemicals

2019-336 CARBORANE-BASED HISTONE DEACETYLASE (HDAC) INHIBITORS

Carborane-Based Histone Deacetylase (HDAC) InhibitorsTech ID: 30179 / UC Case 2019-336-0SUMMARYUCLA researchers from the Department of Chemistry & Biochemistry have developed a new class of Histone Deacetylase (HDAC) inhibitors that can be tuned for isoform specificity and other properties.BACKGROUNDHistone Deacetylase (HDAC) is a ubiquitous enzyme...

Published: 7/19/2023 | Inventor(s): Alexander Spokoyny

Keywords(s): Cns, Life Science Research Tools, Other Reagents, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Other Reagents, Therapeutics, Therapeutics > CNS and Neurology

2018-575 RAPID, SENSITIVE DETECTION OF NUCLEIC ACID SEQUENCES IN ENVIRONMENTAL SAMPLES

Rapid, Sensitive Detection of Nucleic Acid Sequences in Environmental SamplesSUMMARYUCLA Researchers at the California NanoSystems Institute have developed a methodology that permits PCR-based detection of nucleic acid sequences in soil that does not require the isolation of DNA.BACKGROUNDSoil is composed of organic compounds, minerals, gases, liquids...

Published: 9/14/2023 | Inventor(s): Jeffery Miller, Christopher French, Wayne Wong

Keywords(s): Agbio, Life Science Research Tools, Other Reagents

Category(s): Life Science Research Tools, Life Science Research Tools > Other Reagents, Therapeutics > Agtech And Animal Health

2018-451 ELECTROCHEMICAL FLASH FLUORINATION AND RADIOFLUORINATION

Electrochemical Flash Fluorination and RadiofluorinationSUMMARYResearchers led by Saman Sadeghi from the Department of Molecular & Medical Pharmacology at UCLA have developed a new and simple process to make fluorinated organic compounds.BACKGROUNDOrganic compounds functionalized with fluorine atoms have distinguished physical, biological, and chemical...

Published: 7/19/2023 | Inventor(s): Saman Sadeghi

Keywords(s): Life Science Research Tools, Medical Imaging, MRI, Other, Other Reagents, X-Ray

Category(s): Life Science Research Tools, Life Science Research Tools > Other Reagents, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Medical Devices > Medical Imaging > X-Ray

2018-436 GUIDED MAGNETIC NANOSPEARS FOR TARGETED AND HIGH-THROUGHPUT INTRACELLULAR DELIVERY

Guided Magnetic Nanospears For Targeted And High-Throughput Intracellular DeliverySUMMARYUCLA researchers in the Department of Chemistry & Biochemistry and Department of Molecular & Medical Pharmacology have developed novel magnetic nanostructures that can be used to carry and/or deliver biomolecular cargo intracellularly to cells.BACKGROUNDCurrent...

Published: 7/19/2023 | Inventor(s): Steven Jonas, Hsian-Rong Tseng, Shuang Hou, Paul Weiss

Keywords(s): Drug Delivery, Life Science Research Tools, Nanoparticles, Other Reagents

Category(s): Life Science Research Tools, Life Science Research Tools > Other Reagents, Platforms > Drug Delivery, Platforms > Drug Delivery > Nanoparticles

2018-376 CYCLOPENTADIENE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS

Cyclopentadiene Compounds For Use In Bioorthogonal Coupling ReactionsSUMMARYUCLA researchers from the Department of Chemistry and Biochemistry have discovered a class of novel reagents for bioorthogonal reactions. It is stable, dynamically reactive, and readily accessible.BACKGROUNDBioorthogonal reactions link biomolecules to traceable probes that allow...

Published: 7/19/2023 | Inventor(s): Kendall Houk, Jennifer Murphy

Keywords(s): Life Science Research Tools, Other Reagents

Category(s): Life Science Research Tools, Life Science Research Tools > Other Reagents