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Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)

Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...

Published: 2/26/2024 | Inventor(s): Owen Witte, Zhiyuan Mao, Jami Witte, Pavlo Nesterenko, John Lee

Keywords(s): Cancer, cancer antigen, Peptide, peptides, prostate cancer, protein, t-cells

Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

2020-152 Method to Clone Human T Cell Receptors (TCRs) from Single Lymphocytes Based on Functional Profiling

SUMMARY: UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel method to clone human T cell receptors from single lymphocytes. BACKGROUND: Immunotherapy is a growing therapy type for the treatment of disease, especially cancer, by activating or repressing the immune system. One major type...

Published: 7/19/2023 | Inventor(s): Owen Witte, Jami Witte, Pavlo Nesterenko

Keywords(s):

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing

2021-174: TCR ALPHA/BETA SEQUENCES REACTIVE WITH HLA-A*02:01 RESTRCITED EPITOPES WITHIN NSP12 PROTEIN OF SARS-COV-2 VIRUS

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel way to use the sequencing information from T cell mediated immune responses to profile TCR alpha/beta sequences against SARS-CoV-2 virus. This invention has potential to help develop therapeutics or characterize and produce a long-term...

Published: 9/5/2023 | Inventor(s): Owen Witte, Pavlo Nesterenko, Jami Witte

Keywords(s):

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Vaccines, Therapeutics > Immunology And Immunotherapy

2020-884 METHOD TO SEQUENCE MRNA IN SINGLE CELLS IN PARALLEL WITH QUANTIFICATION OF INTRACELLULAR PHENOTYPE

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel methodology that enables droplet-based, single-cell sequencing of RNA in parallel with quantification of intracellular phenotype. They performed intracellular staining with subsequent selection of T Cells expressing certain cytokine or transcription...

Published: 8/29/2023 | Inventor(s): Owen Witte, Pavlo Nesterenko, Jami Witte

Keywords(s): Nucleic Acid Platform Systems, Therapeutics & Vaccines

Category(s): Therapeutics > Oncology

Novel Non-Immunogenic Positron Emission Tomography Gene Reporter (UCLA Case No. 2007-474)

Novel Non-Immunogenic Positron Emission Tomography Gene ReporterTech ID: 30321 / UC Case 2007-474-0SUMMARYUCLA researchers in the Department of Pharmacology and Department of Microbiology, Immunology, & Molecular Genetics have developed a novel positron emission tomography reporter gene to preferentially trap radiolabeled deoxycytidine analogs.BACKGROUNDPositron...

Published: 2/14/2024 | Inventor(s): Owen Witte, Caius Radu, Evan Nair-Gill

Keywords(s): Cell Counting/Imaging, Life Science Research Tools, Medical Imaging, PET, Research Methods

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Counting And Imaging, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > PET

Non-Immunogenic Positron Emission Tomography Gene Reporter Systems (UCLA Case No. 2006-709)

Non-Immunogenic Positron Emission Tomography Gene Reporter SystemsTech ID: 30320 / UC Case 2006-709-0SUMMARYUCLA researchers in the Department of Pharmacology and Department of Microbiology, Immunology, & Molecular Genetics have developed a novel dual gene positron emission tomography reporter system for the enhanced labeling of cells in vitro and...

Published: 2/14/2024 | Inventor(s): Owen Witte, Caius Radu

Keywords(s): Cell Counting/Imaging, Life Science Research Tools, Medical Imaging, PET, Research Methods

2015-288 TRP: Derivation of a Human Neuroendocrine Prostate Cancer Cell Line with Defined Oncogenic Drivers

Derivation Of A Human Neuroendocrine Prostate Cancer Cell Line With Defined Oncogenic DriversSUMMARYResearchers at UCLA have developed a malignant neuroendocrine prostate cancer cell line that was derived from benign human prostate tissue and transformed with the oncogenes MYCN and myristoylated AKT1.BACKGROUNDHuman cell lines are an important component...

Published: 7/19/2023 | Inventor(s): Owen Witte, John Lee

Keywords(s):

Category(s): Life Science Research Tools, Life Science Research Tools > Cell Lines

2019-008 COMPOSITION OF NY-ESO-1-SPECIFIC T CELL RECEPTORS RESTRICTED ON MULTIPLE MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES

Researchers at the UCLA Department of Microbiology, Immunology, and Molecular Genetics have isolated T cell receptors (TCRs) specific for NY-ESO-1 epitopes presented by four MHC molecules, and developed novel approaches to extend TCR gene therapies targeting NY-ESO-1 using these TCRs.BACKGROUNDThe αβ T cell receptor (TCR) determines the unique...

Published: 7/19/2023 | Inventor(s): Owen Witte, Jami Witte, Michael Bethune, Antoni Ribas, Lili Yang, Jonathan Cebon, Katherine Woods, Ashley Knights

Keywords(s): Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

2018-571 SURFACEOME PROFILING OF ADVANCED PROSTATE CANCER TO IDENTIFY TARGET ANTIGENS FOR IMMUNE-BASED THERAPY

Surfaceome Profiling Of Advanced Prostate Cancer To Identify Target Antigens For Immune-Based TherapySUMMARYDr. Witte and colleagues at UCLA have developed a novel approach to identify surface biomarkers and targetable antigens in prostate cancer by combining multiple omics analyses across different cell lines.BACKGROUNDProstate cancer is the most common...

Published: 3/19/2024 | Inventor(s): Owen Witte, John Lee, Nathanael Bangayan

Keywords(s): Life Science Research Tools, Research Methods

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods

2011-043 HUMAN-DERIVED REPORTER GENE FOR POSITRON EMISSION TOMOGRAPHY IMAGING

Human-Derived Reporter Gene for Positron Emission Tomography ImagingSUMMARYUCLA researchers from the Department of Microbiology, Immunology, & Molecular Genetics have developed a novel reporter gene for positron emission tomography imaging of transplanted cells.BACKGROUNDPositron Emission Tomography (PET) Imaging is a useful imaging modality that...

Published: 7/19/2023 | Inventor(s): Owen Witte, Melissa Mccracken, Evan Nair-Gill

Keywords(s): Animal Imaging, Life Science Research Tools, Medical Imaging, PET

Category(s): Life Science Research Tools, Life Science Research Tools > Animal Imaging, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > PET