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Antibody-Drug Conjugates Targeting Stem Cell-Derived Cancer Cells and Tumor Stroma (UCLA Case No. 2020-790)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a versatile antibody-drug conjugate platform utilizing a novel monoclonal antibody that is highly specific at targeting cancer cells and rapidly internalized by those cells for an effective anti-tumor response. BACKGROUND: For decades, an absolute majority of...

Published: 2/13/2024 | Inventor(s): Robert Damoiseaux, Hans Ulmert, Hans David Ulmert, Norbert Peekhaus, Liqun Mao, Claire Storey

Keywords(s): Antibody, diagnostic radionuclides, Imaging, Life Science Research Tools, Medical Imaging, Mesenchymal Stem Cell Derived Cancer Cells, Oncology, PET, therapeutic radionuclides, Tumor microenvironment, Tumor Stroma

Category(s): Medical Devices > Medical Imaging > PET

Intelligent, Adaptive, and Multimodal Data-Driven Epileptogenic Zone Identification and Cognitive Function Mapping Platform (UCLA Case No. 2023-214)

Summary: UCLA researchers in the Departments of Neurology and Electrical and Computer Engineering have developed a data-driven, deep learning-powered software platform to localize epileptogenic tissues in the brain and cognitively map nearby regions. Background: According to the World Health Organization, 50 million people around the world suffer...

Published: 1/24/2024 | Inventor(s): Vwani Roychowdhury, Hiroki Nariai, Richard Staba, Yipeng Zhang

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, Artificial Neural Network, Biomonitoring, Brain Mapping, Condition monitoring, Deep Learning, Digital Health, Digital Pathology, Electroencephalography (EEG), Epilepsy, Hospital Systems And Devices, Medical Device, Medical Devices and Materials, Monitoring (Medicine), Monitoring And Recording Systems, MRI, PET, remote monitoring, Software, Software & Algorithms

Category(s): Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Artificial Intelligence & Machine Learning, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems

2021-144 BIOMARKERS OF DRUG TARGET ENGAGEMENT IN CANCER

UCLA researchers in the Department of Molecular and Medical Pharmacology have identified kinase inhibitors that block glucose consumption and for which [18F]FDG PET can be used as a biomarker, potentially aiding in the early assessment of therapeutic regimen and faster clinical trials.BACKGROUND: Pharmacodynamic biomarkers of drug efficacy...

Published: 9/5/2023 | Inventor(s): Peter Clark, Chiara Ghezzi

Keywords(s): Diagnostic Markers & Platforms, PET

Category(s): Life Science Research Tools > Screening Libraries, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Medical Devices > Medical Imaging > PET, Therapeutics > Oncology

2020-163 POSITRON EMISSION TOMOGRAPHY GUIDED DELIVERY OF MITOCHONDRIAL COMPLEX I INHIBITORS

UCLA researchers in the David Geffen School of Medicine Division of Pulmonary and Critical Care Medicine have developed a novel use of the positron emission tomography (PET) tracer [18F]FBnTP to guide the delivery of mitochondrial complex I inhibitors for the treatment of lung cancers.BACKGROUND: The mitochondria are essential regulators of cellular...

Published: 7/19/2023 | Inventor(s): David Shackelford, Saman Sadeghi, Milica Momcilovic

Keywords(s): Diagnostic Markers & Platforms, Imaging, Medical Imaging, PET, Respiratory & Pulmonary

Category(s): Medical Devices > Medical Imaging > PET, Therapeutics > Oncology, Therapeutics > Respiratory And Pulmonary

2019-231: Radiotracer for Synaptic Imaging

UCLA researchers in the Department of Neurology have synthesized a novel radiotracer that selectively identifies functional synapses for monitoring of synaptic loss in Alzheimer’s patients. BACKGROUND: Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that cannot be prevented, cured or slowed. It affects more than 17...

Published: 7/19/2023 | Inventor(s): Varghese John, Mohammad Parvez Alam, Asa Hatami, Daniel Silverman, Saman Sadeghi

Keywords(s): Cns, Diagnostic Markers & Platforms, Medical Imaging, PET

Category(s): Medical Devices > Medical Imaging > PET

Development and Applications of Multi-modality Engineered Antibody Fragments as New

INTRO SENTENCE:UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a method that allows the dual labeling of antibodies with an optical dye and an 18F radionuclide for multi-modality imaging.BACKGROUND:Multi-modality antibody-based imaging represents an important advance in the medical field, since it can combine...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Animal Imaging, Fluorescence, Life Science Research Tools, Medical Imaging, PET

Category(s): Life Science Research Tools > Animal Imaging, Life Science Research Tools, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > PET, Medical Devices > Medical Imaging > Fluorescence

A Method For Enhancement Of Medical Images

UC Case No. 2019-007SUMMARYUCLA researchers in the Department of Electrical and Computer Engineering have developed an algorithm for hallucination-free resolution enhanced brain MRI images with better quality and superior computational time compared to the current state of the art.BACKGROUNDMedical imaging is a widely used diagnostic tool, yet faces...

Published: 7/19/2023 | Inventor(s): Bahram Jalali, Sifeng He

Keywords(s): CT, Image Processing, Medical Imaging, MRI, PET, Software & Algorithms, X-Ray

Category(s): Software & Algorithms > Image Processing, Software & Algorithms, Medical Devices > Medical Imaging, Software & Algorithms > Data Analytics, Medical Devices > Medical Imaging > CT, Medical Devices > Medical Imaging > MRI, Medical Devices > Medical Imaging > PET, Medical Devices > Medical Imaging > X-Ray

2017-450 MICROSCALE DEVICE AND METHOD FOR PURIFICATION OF RADIOPHARMACEUTICALS

Microscale Device and Method for Purification of RadiopharmaceuticalsTech ID: 30310 / UC Case 2017-450-0SUMMARYUCLA researchers from the Departments of Molecular & Medical Pharmacology and Bioengineering have developed a novel method for the purification of radiopharmaceuticals for the on-demand production of positron emission tomography (PET) tracers.BACKGROUNDPositron...

Published: 7/19/2023 | Inventor(s): R. Michael Van Dam, Seunghyun Noel Ha, Jason Jones, Jimmy Ly, Stephen Liu, Shilin Cheung

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Medical Imaging, PET

Category(s): Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Diagnostic Platform Technologies, Medical Devices > Medical Imaging > PET

2017-380 DEVICE AND METHOD FOR MICROSCALE CHEMICAL REACTIONS

Device and Method for Microscale Chemical ReactionsTech ID: 30291 / UC Case 2017-380-0SUMMARYUCLA researchers in the Departments of Bioengineering and Molecular and Medical Pharmacology have developed a passive microfluidic reactor chip with a simplified design that is less costly than existing microfluidic chips.BACKGROUNDAlthough positron emission...

Published: 7/19/2023 | Inventor(s): R. Michael Van Dam, Jia Wang

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Medical Imaging, PET

Category(s): Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Diagnostic Platform Technologies, Medical Devices > Medical Imaging > PET

2017-185 METHOD FOR CONCENTRATION AND FORMULATION OF RADIOPHARMACEUTICALS

Method For Concentration And Formulation Of RadiopharmaceuticalsTech ID: 30269 / UC Case 2017-185-0SUMMARYResearchers at the UCLA Department of Medical and Molecular Pharmacology have developed a compact microfluidic device that is able to achieve rapid concentration and/or reformulation of PET tracers after HPLC purification.BACKGROUNDPositron emission...

Published: 7/19/2023 | Inventor(s): R. Michael Van Dam, Philip Hongsean Chao

Keywords(s): Life Science Research Tools, Medical Imaging, Microfluidics And Mem's, PET

Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > PET

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