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2022-140 Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue Using Deep Learning
SUMMARY: UCLA researchers in the Departments of Bioengineering and Electrical and Computer Engineering have developed a deep learning-based algorithm that can detect and quantify the breast cancer marker human epidermal growth factor receptor 2 (HER2) in microscopic images without the need for time-consuming immunohistochemical staining (IHC). BACKGROUND:...
Published: 4/9/2024
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Inventor(s):
Aydogan Ozcan
,
Yair Rivenson
,
Bijie Bai
,
Hongda Wang
Keywords(s):
Artifical Intelligence (Machine Learning, Data Mining)
,
Biomarker
,
Bladder Cancer
,
Breast Cancer
,
Cancer
,
Cancer Immunotherapy
,
Computer Aided Learning
,
Diagnostic Markers & Platforms
,
Diagnostic Test
,
Fluorescence
,
Fluorescent Labelling
,
HER2/Neu
,
Histology
,
Immune System
,
Immunohistochemistry
,
Life Science Research Tools
,
Machine Learning
,
Optics
,
Research Methods
,
Unsupervised Learning
Category(s):
Life Science Research Tools
,
Life Science Research Tools >
Research Methods
,
Diagnostic Markers
,
Diagnostic Markers > Immunology
,
Medical Devices > Medical Imaging
,
Medical Devices > Medical Imaging > Fluorescence
,
Software & Algorithms > Artificial Intelligence & Machine Learning
,
Optics & Photonics
Optimized Lentiviral Vector for Stem Cell Gene Therapy of Hemoglobinopathies
UCLA Case No. 2017-460 Summary UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. Background Sickle...
Published: 1/23/2024
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Inventor(s):
Donald Kohn
,
Roger Hollis
,
Richard Morgan
Keywords(s):
Drug Delivery
,
Gene Editing Systems
,
Gene Therapy
,
Genetic Disease
,
Life Science Research Tools
,
Plasmids / Vectors
,
Research Methods
,
Therapeutics & Vaccines
,
Viral Delivery Systems
Category(s):
Life Science Research Tools > Plasmids/Vectors
,
Life Science Research Tools
,
Life Science Research Tools >
Research Methods
,
Platforms > Drug Delivery
,
Therapeutics
,
Platforms > Drug Delivery > Viral Delivery Systems
,
Therapeutics > Gene Therapy And Editing
2020-182 MITOCHONDRIAL DNA PROSTATE CANCER MARKER AND RELATED SYSTEMS AND METHODS
Researchers in UCLA Department of Human Genetics have developed a novel method of using the mitochondrial genome of prostate cancer patients to predict which tumours are likely to become lethal.BACKGROUND:Prostate cancer remains the most prevalent non-skin cancer in men. Most studies of the prostate cancer genome focused on mutations in the nuclear...
Published: 7/19/2023
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Inventor(s):
Paul Boutros
,
Robert Bristow
Keywords(s):
Artifical Intelligence (Machine Learning, Data Mining)
,
Bioinformatics
,
Diagnostic Markers & Platforms
,
Diagnostic Platform Technologies (E.G. Microfluidics)
,
Life Science Research Tools
,
Oncology
,
Research Methods
,
Software
,
Software & Algorithms
Category(s):
Life Science Research Tools >
Research Methods
,
Platforms > Diagnostic Platform Technologies
,
Therapeutics > Oncology
,
Software & Algorithms > Bioinformatics
,
Software & Algorithms > Artificial Intelligence & Machine Learning
,
Software & Algorithms > Programs
2019-649 COMPREHENSIVE IDENTIFICATION OF INTERACTING PROTEIN TARGETS USING MRNA DISPLAY OF UNIFORM LIBRARIES
UCLA researchers in the Department of Pharmacology have developed a novel human exon library for mRNA display detection of protein-protein interactions. BACKGROUND:Proteins control all biological functions within a cell. The majority of proteins require interaction with other proteins as partners, to achieve their proper function in cellular machineries....
Published: 7/19/2023
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Inventor(s):
Ren Sun
Keywords(s):
Life Science Research Tools
,
Other
,
Research Methods
,
Targets And Assays
Category(s):
Life Science Research Tools >
Research Methods
,
Diagnostic Markers > Targets And Assays
2019-480: DNA Methylation Based Estimator of Telomere Length
UCLA researchers in the Department of Human Genetics and Biostatistics have developed a tool that utilizes DNA methylation biomarkers to estimate telomere length. The technology has great potential to monitor and evaluate interventions applied to age-related conditions.BACKGROUND: Telomeres are repetitive nucleotide sequences at the end of chromosomes...
Published: 7/19/2023
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Inventor(s):
Stefan Horvath
Keywords(s):
Aging
,
Diagnostic Markers & Platforms
,
Diagnostic Platform Technologies (E.G. Microfluidics)
,
Life Science Research Tools
,
Research Methods
Category(s):
Life Science Research Tools >
Research Methods
,
Diagnostic Markers > Aging
,
Platforms > Diagnostic Platform Technologies
Cancer Detection and Treatment Using Atomic Force Microscopy (AFM)
UC Case No. 2006-707SUMMARY:UCLA Researchers in the Department of Chemistry and Biochemistry have applied atomic force microscopy (AFM) to accurately detect tumor cells based on their nanomechanical properties.BACKGROUND:Currently tumor cells are detected by histomorphological analysis using stains and antibodies to highlight morphological changes and...
Published: 7/19/2023
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Inventor(s):
James Gimzewski
,
Jian Yu Rao
,
Yusheng Jin
,
Sarah Cross
Keywords(s):
Diagnostic Markers & Platforms
,
Diagnostic Platform Technologies (E.G. Microfluidics)
,
Life Science Research Tools
,
Medical Imaging
,
Microscopy And Imaging
,
Oncology
,
Research Methods
,
Targets And Assays
Category(s):
Life Science Research Tools > Microscopy And Imaging
,
Life Science Research Tools >
Research Methods
,
Platforms > Diagnostic Platform Technologies
,
Therapeutics > Oncology > Oncology (Small Molecules)
2019-046 A METHOD FOR MEASUREMENT OF CURCUMIN AND RELATED COMPOUNDS IN BIOLOGICAL SAMPLES
INTRDUCTION:UCLA scientists from the Department of Psychiatry and Biobehavioral Sciences, in collaboration with colleagues from California State University, Channel Islands and Shenzhen University, have developed a sensitive analytical method for measuring curcumin and related compounds in complex biological samples.BACKGROUND:Curcumin is a compound...
Published: 9/14/2023
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Inventor(s):
Keywords(s):
Life Science Research Tools
,
Research Methods
Category(s):
Life Science Research Tools >
Research Methods
2018-920 INTRA-PROCEDURE IMAGE-BASED FLOW QUANTIFICATION (FOR TREATMENT EVALUATION)
INTRODUCTION:UCLA researchers in the Department of Radiology have developed a new method for analyzing portal vein blood blow at transjugular intrahepatic portosystemic shunt (TIPS) creation.BACKGROUND:TIPS creation is a common interventional method for the treatment of portal hypertension. However, post-procedure complications can arise, which often...
Published: 7/19/2023
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Inventor(s):
Keywords(s):
Diagnostic Markers & Platforms
,
Gastroenterology & Digestive Disease
,
Life Science Research Tools
,
Research Methods
Category(s):
Life Science Research Tools >
Research Methods
,
Therapeutics > Gastroenterology
2018-734 MITOCHONDRIAL DNA DELETION MUTATION ASSAY
INTRODUCTION:UCLA researchers in the Department of Geriatric Medicine have developed a novel method for the concurrent quantification of mitochondrial DNA content and mutation frequency in both single cells and tissue homogenates.BACKGROUND:The human mitochondrial DNA (mtDNA) genome consists of about 37 genes, all of which are essential for mitochondrial...
Published: 7/19/2023
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Inventor(s):
Jonathan Wanagat
,
Allen Herbst
Keywords(s):
Aging
,
Diagnostic Markers & Platforms
,
Life Science Research Tools
,
Research Methods
Category(s):
Life Science Research Tools >
Research Methods
,
Diagnostic Markers > Aging
2018-167 A NEW APPROACH TO HIGH THROUGHPUT DRUG DISCOVERY IN GPCRS USING MICROED
INTRODUCTION:UCLA researchers in the Department of Physiology have proposed a new and powerful method for unbiased structure based high throughput drug discovery for G-protein coupled receptors (GPCRs) using microcrystal electron diffraction (MicroED). BACKGROUND:X-ray crystallography is one of the techniques for determining protein structures at atomic...
Published: 7/19/2023
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Inventor(s):
Tamir Gonen
Keywords(s):
Life Science Research Tools
,
Research Methods
,
Targets And Assays
Category(s):
Life Science Research Tools >
Research Methods
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