Search Results - robert+damoiseaux

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A Programming Language to Execute Biological Experiments (Command Line Biology/Biowrapper) (Case No. 2024-049)

Intro Sentence: UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a programming language to automate biological experiments. Background: Manual labor is a common bottleneck in biological sciences, with automation technology still being unobtainable and impractical for most scientists in biomedical research....

Published: 4/4/2024 | Inventor(s): Robert Damoiseaux, Michael Mellody, Ronan Bennett, Alejandro Huerta, Rutu Shah

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, artificial-intelligent materials, Automation, generative artificial intelligence, Machine Learning, machine learning modeling, Medical artificial intelligence (AI), Programmable Logic Device

Category(s): Software & Algorithms, Software & Algorithms > Data Analytics, Software & Algorithms > Programs, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Research Methods

Antibody-Drug Conjugates Targeting Stem Cell-Derived Cancer Cells and Tumor Stroma (UCLA Case No. 2020-790)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a versatile antibody-drug conjugate platform utilizing a novel monoclonal antibody that is highly specific at targeting cancer cells and rapidly internalized by those cells for an effective anti-tumor response. BACKGROUND: For decades, an absolute majority of...

Published: 2/13/2024 | Inventor(s): Robert Damoiseaux, Hans Ulmert, Hans David Ulmert, Norbert Peekhaus, Liqun Mao, Claire Storey

Keywords(s): Antibody, diagnostic radionuclides, Imaging, Life Science Research Tools, Medical Imaging, Mesenchymal Stem Cell Derived Cancer Cells, Oncology, PET, therapeutic radionuclides, Tumor microenvironment, Tumor Stroma

Category(s): Medical Devices > Medical Imaging > PET

2022-177: DRUG COMBINATION TO INHIBIT BOTH MPRO AND PLPRO PROTEASES OF SARS-COV-2

SUMMARY: UCLA researchers in the Department of Neurology have developed a novel small-molecule protease inhibitor cocktail to robustly suppress COVID-19 infection. INTRODUCTION: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Despite the development of vaccines, COVID-19 was the third-leading cause of death in the U.S. in 2021,...

Published: 9/5/2023 | Inventor(s): Varghese John, Robert Damoiseaux, Melody (Man Hing) Li

Keywords(s):

Category(s): Therapeutics, Therapeutics > Infectious Diseases, Therapeutics > Infectious Diseases > COVID

2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS

Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo, Maani Archang, Robert Damoiseaux, Doyeon Koo

Keywords(s): Antibody, B Cell, Bioassay, Cell Counting/Imaging, Cellular Differentiation, Cytometry, Flow Cytometry, Fluorescence, Hybridoma Technology, Secretory Component, T Cell, Targets And Assays

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

2019-255 DISCOVERY OF NOVEL ANTI-INFECTIVES FOR GRAM NEGATIVE PATHOGENS

UCLA researchers in the California NanoSystems Institute have discovered novel and potent therapeutic agents against Burkholderia bacteria, E. Coli and pseudomonas bacterial infections through cell-based phenotypic screening that are more effective than existing treatments. BACKGROUND: Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) cause...

Published: 7/19/2023 | Inventor(s): Jeffery Miller, Robert Damoiseaux

Keywords(s): Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics > Infectious Diseases

2020-806 SMALL MOLECULE DRUGS FOR CORONAVIRUS INFECTIONS

UCLA researchers in the Department of Molecular and Medical Pharmacology have discovered a group of small molecule compounds that are active against live SARS-CoV-2 at therapeutically relevant concentrations.BACKGROUND: COVID-19 is a global pandemic caused by a newly discovered coronavirus, severe acute respiratory syndrome-related coronavirus (SARS-CoV-2)....

Published: 9/12/2023 | Inventor(s): Vaithilingaraja Arumugaswami, Robert Damoiseaux

Keywords(s): Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics > Infectious Diseases

2015-811 MI-181: A Potent Small Synthetic Microtubule-Targeting AntiCancer Agent

MI-181: A Potent Small Synthetic Microtubule-Targeting Anticancer AgentSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry and Department of Molecular & Medical Pharmacology have discovered compound MI-181 and successfully synthesized its derivatives and analogs, which have the potential for use in cancer therapy by arresting...

Published: 7/19/2023 | Inventor(s): Robert Damoiseaux, Jorge Torres, Todd Yeates, Dan Mcnamara, Silvia Senese

Keywords(s): Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)