Search Results - song+li

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Synthetic Viscoelastic Activating Cells (SynVACs) for T cell engineering (UCLA Case No. 2023-190)

UCLA researchers in the Department of Bioengineering have developed a novel microfluidic device that produces synthetic viscoelastic cells for efficacious therapeutic T cell activation. BACKGROUND: T cell-based therapies, such as the chimeric antigen receptor (CAR) T cell therapy, represents a significant advancement in cancer treatment, particularly...

Published: 3/6/2024 | Inventor(s): Zeyang Liu, Song Li, Lili Yang, Yan-Ruide Li

Keywords(s): CAR-T cell therapy, Synthetic antigen presenting cells (SynVACs), T Cell, T cell based therapy, T-cell activation, T-cell engineering, t-cells

Category(s): Therapeutics > Oncology

Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)

UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....

Published: 2/26/2024 | Inventor(s): Mohammad Hasani-Sadrabadi, Song Li, Manish Butte

Keywords(s): aAPCs, Aging, artificial presenting cells, cytokines, elderly, immunosenescence, microparticles, platform technology, SARS-CoV-2, T memory stem cells, TMSCs, Vaccines

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Oncology

2021-003 A Chemical Cocktail Driving Expansion of Myogenic Stem Cells

SUMMARY: UCLA researchers in the Department of Bioengineering have developed a novel chemical cocktail for enhancing myogenic stem cell expansion both in vitro and in situ that could lead to more affordable and faster development of stem cell-based therapies and chemical delivery technologies for muscle regeneration. BACKGROUND: Skeletal muscle tissue...

Published: 8/25/2023 | Inventor(s): Song Li

Keywords(s):

Category(s): Therapeutics, Therapeutics > Musculoskeletal Disease

Immunoactive Microparticles and Uses Thereof (UCLA Case No. 2020-200)

SUMMARY: UCLA Researchers from the division of Immunology in the David Geffen School of Medicine have developed an improved method of stimulating anti-tumor T-cells for use in cancer immunotherapy. BACKGROUND: Cancer immunotherapy, a therapeutic strategy whereby a patient’s own immune system is reequipped to attack cancer cells, promises more...

Published: 4/9/2024 | Inventor(s): Manish Butte, Mohammad Hasani-Sadrabadi, Fatemeh Sadat Majedi, Song Li

Keywords(s):

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Materials > Nanotechnology

Novel Vaginal Drug Delivery Device (UCLA Case No. 2020-444)

Summary: UCLA researchers in the Departments of Biomedical Engineering and Medicine have developed vaginal drug delivery devices for the administration of contraceptives and antibiotics. Background: Globally, 1.9 billion women of reproductive age (15-49 years) use contraceptives. An additional 190 million women would use phrophylactics/contraceptives...

Published: 2/29/2024 | Inventor(s): Leena Nathan, Song Li, Tamara Grisales, Mohammad Hasani-Sadrabadi

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Platforms > Drug Delivery > Other Polymers

2021-052 BOOST CARDIAC REPROGRAMMING BY MODULATING IMMUNE CELLS AND MICROENVIRONMENT

SUMMARYResearchers from the Department of Bioengineering at UCLA have identified key players in in both preventing and boosting cardiac reprogramming. This innovation can be used for in vivo human cardiac reprogramming to provide a novel approach for cardiac regeneration in the clinic and other fields of regenerative medicine. BACKGROUNDIschemic heart...

Published: 9/5/2023 | Inventor(s): Song Li

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics, Therapeutics > Cardiovascular

2020-421 EXTRACELLULAR VESICLES DERIVED FROM INDUCED PLURIPOTENT STEM CELLS FOR IMMUNOMODULATION

UCLA researchers in the Department of Bioengineering have developed a method to boost extracellular vesicles' (EVs) production and potency, potentially allowing large-scale clinical-grade EV manufacture for immunomodulatory therapeutics. BACKGROUNDExtracellular vesicles (EVs) are one of the most important mediators of cell-to-cell communication. EVs...

Published: 7/19/2023 | Inventor(s): Jana Zarubova, Mohammad Hasani-Sadrabadi, Song Li

Keywords(s): Immunology, Therapeutics & Vaccines, Transplant Rejection

Category(s): Life Science Research Tools > Research Methods, Therapeutics > Agtech And Animal Health, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2020-451 AMIOTIC MEMBRANE FOR MYOCARDIAL REPAIR

UCLA researchers in the Department of Bioengineering have developed a novel injectable human amniotic membrane matrix for the treatment of heart failure.BACKGROUND: Myocardial infarction (MI) associated heart failure is the leading cause of death in the United States. In 2015, heart failure affected about 40 million people worldwide. Around 2% of adults...

Published: 7/19/2023 | Inventor(s): Song Li, Randall Lee

Keywords(s): Cardiovascular, Therapeutics & Vaccines

Category(s): Therapeutics > Cardiovascular

2019-898 NEURAL CREST STEM CELL THERAPIES FOR DENERVATION ATROPHY

UCLA researchers in the Department of Bioengineering have developed an innovative cell-based therapy addressing the recovery from denervation atrophy by intramuscularly delivering neural crest stem cells in various constructs.BACKGROUND:Muscular denervation atrophy of various etiologies can result in weakness or loss of functional independence, as well...

Published: 7/19/2023 | Inventor(s): Song Li, Yuan-Yu Hsueh

Keywords(s): Musculoskeletal Disease, Therapeutics & Vaccines

Category(s): Therapeutics > Musculoskeletal Disease