Search Results - tumor

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Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Antitumor Immunity (UCLA Case No. 2020-858)
UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...
Published: 3/6/2024   |   Inventor(s): Cun-Yu Wang, Jia Lingfei
Keywords(s): Cancer stem cells, Epigenetics, Immunooncology, Oncology Immunotherapy, Tumor
Category(s): Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Gene Therapy And Editing
Antitumor activity of NKTR-214 alone or in combination with anti-PD-1 therapy in tumors resistant to anti-PD-1 (UCLA Case No. 2019-254)
UCLA researchers have discovered a therapy for anti-PD-1 resistant tumors in colon carcinoma patients. A small molecule therapeutic alone or in combination with immune-checkpoint blockade (ICB) therapy exhibits tumor remission even in sublines with mutated signalling pathways that have rendered them ICB resistant. BACKGROUND: Immunotherapy, the...
Published: 2/15/2024   |   Inventor(s): Antoni Ribas
Keywords(s): Colon carcinoma, Immune checkpoint blockade, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), PD-1, PD-L1, Resistant tumors, Signaling pathways, Small molecule therapeutics, Tumor
Category(s): Life Science Research Tools, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)
Novel Method to Group Pixels for Medical Imaging (UCLA Case No. 2022-290)
Summary: UCLA researchers in the Department of Radiological Sciences have developed a new computational pipeline for identifying lesions in MRI data. Background: Prostate cancer is one of the most common cancer types with 12.6% of men diagnosed within their lifetime. Prostate cancer ranks as the 2nd leading cause of cancer-related deaths in the...
Published: 7/31/2023   |   Inventor(s): Ashley Yeager
Keywords(s): AI algorithms, Algorithm, algorithmic cancer detection, Cancer, cancer detection, DICOM, multiparametric MRI (mpMRI), prostate cancer, Radiology, Software & Algorithms, Tumor, Tumor Marker
Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Digital Health
2023-009: Repurposing Native Cytokine Receptor Signaling for Adoptive T Cell Therapy of Cancer
SUMMARY: UCLA researchers in the Department of Radiation Oncology at the School of Medicine have identified a cytokine receptor endowing adoptively transferred T cells with new functions that enhance the potency of adoptively transferred T cells for the treatment of solid tumors, namely by restoring their functionality in the absence of conditioning...
Published: 7/19/2023   |   Inventor(s): Anusha Kalbasi
Keywords(s): Cancer, Immunotherapy, Tumor
Category(s): Life Science Research Tools, Therapeutics
2021-344 Biopsy-Free In Vivo Virtual Histology of Skin Using Deep Learning
Summary: UCLA researchers in the Departments of Electrical and Computer Engineering & Bioengineering have developed a non-invasive, biopsy-free technique for in vivo virtual histology of skin cancer using deep learning. Background: Tissue biopsies have often been used to diagnose skin cancers in patients. These procedures are generally cumbersome...
Published: 7/19/2023   |   Inventor(s): Aydogan Ozcan, Jingxi Li, Yair Rivenson, Xiaoran Zhang, Philip Scumpia, Jason Garfinkel, Gennady Rubinstein
Keywords(s): Artificial Intelligence, Biopsy, Cancer, Confocal Microscopy, Diagnostic Test, Histology, Image Resolution, Invasiveness Of Surgical Procedures, Melanoma, Optics, Skin, Software, Tissue (Biology), Tumor
Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Electrical > Imaging, Medical Devices > Medical Imaging, Optics & Photonics