Summary
UCLA researchers in the Department of Medicine have developed a novel graphene oxide (GO) based material with significantly enhanced antibacterial effects with maximized surface display of carbon radicals.
Background
Adhesion of bacteria to surfaces of human tissue, biomaterials and medical devices significantly increases the risk of infection in patients. Graphene oxide (GO) materials have demonstrated antibacterial properties across a spectrum of bacteria. However, the most proximal structure activity relationships that lead to antibacterial effects in GO are still elusive. Moreover, most of the reported GO materials exhibit antibacterial effects of only modest severity. A deeper understanding of the specific functional groups that explain the antibacterial effects of GO is crucial for developing an improved GO formulation to enhance the antibacterial effects for clinically important material surfaces.
Innovation
UCLA researchers in the Department of Medicine have developed a novel GO based material with significantly enhanced antibacterial effects. They identified carbon radicals (•C) as the key functionality to GO-induced antibacterial effects. To maximize the surface display of carbon radicals, hydrated GO (hGO) is coated on silicone or glass surfaces with a special method that allows direct contact of carbon radicals with bacterial surfaces. The bacterial killing efficiency exhibited by hGO is of a 10-fold increase over pristine GO. Moreover, the immobilization of the functionalized hGO on glass or silicone surfaces allowed the material to repel antibiotic-resistant bacteria by direct physicochemical interaction and damage to bacterial membranes, which was not seen under traditional resistance mechanisms.
Applications
▶ Medical device coating
▶ Antibacterial additives to biomaterials
▶ Biosensors surface coating
▶ Wound treatment
▶ Water filtration
Advantages
▶ Increased antibacterial efficacy
▶ Effective against antibiotic-resistant bacteria
▶ Efficient surface coating
State Of Development
▶ Proof of principle experiments demonstrated with repelling of antibiotic resistant E. coli by hGO coated glass and silicone catheter surfaces