INTRODUCTION:
UCLA researchers in the Departments of Bioengineering and Dentistry have developed a patch-based drug delivery system for dental applications.
BACKGROUND:
Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth, and it is estimated that 50% of the U.S. population suffers from some type of periodontal disease. However, most available treatment options have limited efficacy due to poor patient compliance and short treatment time. Therefore, there is a strong need for a new treatment platform that facilitates patient compliance and extended drug release.
INNOVATION:
UCLA researchers have developed a minimally invasive microneedle patch-based drug delivery system for the treatment of periodontal diseases. The patch allows the extended release of molecules such as antibiotics, anti-inflammatory compounds, growth factors, and/or cytokines to help reduce the tissue inflammation and promote bone regeneration. In addition, unlike many other delivery systems, there is no need for further sealing via membrane, adhesive, or suture.
POTENTIAL APPLICATIONS:
• Periodontal disease treatment
ADVANTAGES:
• Minimally invasive
• Tunable design
• Extended drug release (days)
• No need for sealing
• Low cost
• Scalable
DEVELOPMENT-TO-DATE:
This invention has been developed and tested ex vivo.