2011-723 Transgenic Mice for Endothelial Cell Research (Ve-Cadherin Cre-Recombinase - Rosa26r-LacZ)

Summary

UCLA researchers have developed a dual transgenic animal that enables genetic tracing of endothelial cells and their derivatives.

Background

Disturbances in endothelial gene expression contribute to vascular morphogenesis and tumor growth. Over the past century, the mouse has emerged as the premier mammalian model system for genetic research. Its genetic and physiological similarities to humans, as well as the ease with which its genome can be manipulated, make it especially attractive as models for human disease. Thus, mouse models that enable genetic tracing of endothelial cells would be of great use to vascular biologists.

Innovation

UCLA researchers have developed a dual transgenic animal that enables genetic tracing of endothelial cells and their derivatives. Specifically, endothelial cells are labeled with LacZ, and VE-Cadherin, an endothelial-specific promoter, drives Cre-recombinase.

Applications

Use as a model system to investigate endothelial gene expression in the context of either physiological or pathological conditions

Advantages

Endothelial-specific gene recombination ensures that only endothelial cells are labeled with LacZ

State Of Development

The mouse model has been developed, validated, and communicated to the scientific community.

Patent Information:
For More Information:
Tara Davidoff
Industry Research and Material Transfer Officer
Tara.davidoff@tdg.ucla.edu
Inventors: