2021-360 PERSONALIZED CONTROL OF HEMODYNAMICS (PCH) IN HIGH-RISK SURGERY PATIENTS

SUMMARY:

UCLA researchers have developed a personalized and automated control system of a patient’s hemodynamics during surgery.

BACKGROUND:

Hemodynamics is the study of blood flow, measuring a variety of inter-connected metrics including oxygenation, cardiac efficiency and output. It provides critical metrics that informs and enables physicians to gauge patient health prior to, during, and after surgical operations. Hemodynamic management is crucial for physicians administering anesthetics, as poor management can cause detrimental outcomes and post-operative injuries such as acute kidney injury (AKI). In the current state of the field, hemodynamic management fails to quickly adjust and accommodate to the personalized needs of patients during surgery. Therefore, there is a need for a personalized and targeted hemodynamic management system for patients that undergo surgery in the operating room.

INNOVATION:

UCLA researchers have developed a system for personalized control of hemodynamics (PCH) for precision management of blood pressure during high-risk surgeries. The system allows physicians to tailor anesthetic management of patients based on their unique physiology and biochemistry response profiles. Management of patients’ blood pressure and hemodynamic characteristics is a critical aspect of precision monitoring that overcomes previous barriers in operating room procedures.  The proposed PCH system could enable automated hemodynamic adjustments within a narrow and appropriate range that is personalized for each patient. Furthermore, this novel PCH system provides an invaluable tool for perioperative management to ensure improved patient outcome.   

POTENTIAL APPLICATIONS:

  • High-risk surgical monitoring
  • AI-assisted anesthesia monitoring
  • Intraoperative blood pressure management
  • Blood pressure control

ADVANTAGES:

  • Patient-specific operative management
  • Improved surgical outcomes for high-risk procedures (e.g. cardiac)
  • Decreased patient morbidity
  • Reduction in number of post-operative AKI’s and comorbidities
  • Reduction in economic burden to hospitals and individuals suffering from postoperative injuries
  • Improvement in hospital operative reputation

DEVELOPMENT TO DATE:

First successful demonstration by control of blood pressure to a desired mean arterial pressure prospective in animal test.

DEMONSTRATION VIDEO:

Personalized Control of Hemodynamics - (2021-360)

Patent Information:
For More Information:
Joel Kehle
Business Development Officer
joel.kehle@tdg.ucla.edu
Inventors:
Chih-Ming Ho
Soban Umar
Jure Marijic
Daniel Garcia
Jinyoung Brian Jeong
Michael Zargari