Anti-PSA IgG
SUMMARY
Researchers at UCLA have developed chimeric IgG specific for prostate-specific antigen (PSA) in human and mouse cells.
BACKGROUND
Prostate-specific antigen (PSA) is a substance made by cells in the prostate gland. Physicians use high PSA levels (above 4 nanograms per milliliter) as a blood biomarker for prostate cancer. Given this, a PSA antibody with high specificity to human PSA would benefit clinical diagnosis of prostate cancer.
INNOVATION
Researchers at UCLA have developed a chimeric IgG specific antibody for the PSA in human and mouse cells. The variable regions of this antibody are those of the murine monoclonal antibody AR47.47. This novel antibody was expressed in murine myeloma cell lines, and is therefore cost efficient and easy to produce. It is properly assembled and secreted and binds PSA antigen
APPLICATIONS
- Detect levels of PSA in prostate cancer patients
- Detect levels of PSA in experimental procedures performed in research laboratories
ADVANTAGES
Specific to PSA
Developed in murine myeloma cell lines:
- Cost-efficient
- Easy to produce large quantities of antibody
STATE OF DEVELOPMENT
Antibody has been developed and validated.