Nanoparticulate Mineralized Collagen Glycosaminoglycan Scaffold with an Anti-Resorption Factor (UCLA Cases 2018-585, 2021-364)

SUMMARY

Researchers in the Division of Plastic and Reconstructive Surgery at the UCLA David Geffen School of Medicine and the Institute of Genomic Biology at the University of Illinois Urbana Champaign (UIUC) have developed novel methods to incorporate anti-resorption factor into nanoparticulate mineralized collagen glycosaminoglycan scaffold to maximize bone regeneration.

BACKGROUND

Skeletal regenerative medicine addresses the current limitations for treating large osseous defects secondary to congenital, traumatic, and post-oncologic conditions. The current state of the art for bone replacement is either autologous bone grafting, or bone tissue engineering. Autologous bone grafting is limited by the donor site morbidity and the limited availability of autologous bone, which have resulted in the development of various alloplastic implants and usage of recombinant growth factors. However, complicated wounds such as radiated tissues or composite tissue deficiencies are likely to experience alloplastic implant failure from extrusion, infection, and other complications caused by growth factors use. Thus, there is an urgent need for a universal solution to clinically minimize or eliminate the reliance on artificial implants and growth factors.

INNOVATION

Researchers at UCLA and UIUC have previously discovered a mineralized collagen glycosaminoglycan material that is able to induce robust osteogenesis without growth factor stimulation or addition of stem cells. A novel method is proposed to incorporate an anti-resorption factor to this scaffold in order to augment bone regeneration by a temporary blockade of osteoclast activation.

APPLICATIONS

Bone regeneration

ADVANTAGES

This novel method is based on a biomaterial and an inhibitory factor rather than a growth factor.

STATE OF DEVELOPMENT

Have completed proof of concept experiments.

KEYWORDS: osteogenesis, bone regeneration, bone repair, bone healing

RELATED MATERIALS

• Ren, X., Bischoff, D., Weisgerber, D.W., Lewis, M.S., Tu, V., Yamaguchi, D.T., Miller, T.A., Harley, B.A. and Lee, J.C., Osteogenesis on nanoparticulate mineralized collagen scaffolds via autogenous activation of the canonical BMP receptor signaling pathway, Biomaterials, 2015.
• Maxhimer, J.B., Bradley, J.P. and Lee, J.C., Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine, Genes & diseases, 2015.
• Lee, J.C., Pereira, C.T., Ren, X., Huang, W., Bischoff, D., Weisgerber, D.W., Yamaguchi, D.T., Harley, B.A. and Miller, T.A., Optimizing collagen scaffolds for bone engineering: effects of cross-linking and mineral content on structural contraction and osteogenesis, The Journal of craniofacial surgery, 2015.
• Ren, X., Tu, V., Bischoff, D., Weisgerber, D.W., Lewis, M.S., Yamaguchi, D.T., Miller, T.A., Harley, B.A. and Lee, J.C., Nanoparticulate mineralized collagen scaffolds induce in vivo bone regeneration independent of progenitor cell loading or exogenous growth factor stimulation, Biomaterials, 2016.
• Ren, X., Weisgerber, D.W., Bischoff, D., Lewis, M.S., Reid, R.R., He, T.C., Yamaguchi, D.T., Miller, T.A., Harley, B.A. and Lee, J.C., Nanoparticulate Mineralized Collagen Scaffolds and BMP-9 Induce a Long-Term Bone Cartilage Construct in Human Mesenchymal Stem Cells, Advanced healthcare materials, 2016.
• Lee, J.C. and Volpicelli, E.J., Bioinspired collagen scaffolds in cranial bone regeneration: From bedside to bench, Advanced healthcare materials, 2017.
• Lee, J.C., Zhou, Q., Ren, X., Bischoff, D., Weisgerber, D., Yamaguchi, D., Miller, T.A. and Harley, B.A., Differential Osteogenic Signaling Pathways in Human Mesenchymal Stem Cells on Collagen Glycosaminoglycan Scaffolds, Plastic and Reconstructive Surgery Global Open, 2017.