Biotransformation of Per- and Poly-Fluorinated Substances by Fungi (Case No. 2020-458)

Summary:

UCLA researchers in the Department of Civil and Environmental Engineering have developed a method to biodegrade a common perfluoroalkyl manufacturing precursor using various fungal strains.

Background:

Per- and polyfluoroalkyl substances (PFAS) are ubiquitously utilized in a variety of consumer, industrial, and military products. Sometimes referred to as “forever chemicals,” they don’t break down in the human body and can accumulate over time.  Evidence suggests that there are potential adverse health impacts from exposure to PFAS. These materials are resistant to most conventional chemical and microbial clean-up approaches, which creates a need for an effective remediation technology.

Innovation:

UCLA researchers in the Department of Civil and Environmental Engineering have isolated and analyzed several fungi able to biotransform common PFSA, fluorotelomer alcohol (6:2 FTOH), into less toxic metabolites with lower overall yields of undesired PFCAs. The cultures are capable of significantly reducing PFCA production in a matter of weeks. Importantly, this study is the first effort to investigate the effects of nutrients on fungal transformation of 6:2 FTOH and to elucidate the role of various enzymes which will enable waste treatments that lead to little to no PFCA accumulation.

Ted Talk:

Bioremediation: How biology heals the earth naturally

Potential Applications:

  • Remediation of soil contaminated with PFAS
  • Chemical processing
  • Environmental pollutant control

Advantages:

  • Highly efficient transformation
  • Limited to no accumulation of PFCAs
  • Mild and controllable reaction conditions
  • Degradation of 6:2 FTOH within weeks
  • Investigation of the role of nutrients on fungal metabolite production

Related Materials:

Development Status:

Demonstrated on 8 fungi varieties both cultured in the laboratory and isolated from contaminated environments

Patent Information:
For More Information:
Ed Beres
Business Development Officer
edward.beres@tdg.ucla.edu
Inventors:
Shaily Mahendra