Summary:
UCLA researchers in the Department of Bioengineering have developed a novel implantable microtubular pacemaker for reliable and comfortable pacing for patients with arrythmias.
Background:
Cardiac pacemakers are essential devices used to manage abnormal heart rhythms, or arrythmias, by sending electrical pulses to prompt the heart to beat at a regular pace. Traditional pacemakers, however, have several drawbacks. They require invasive surgery to implant and connect wires to the heart, which can sometimes lead to complications like infections, wire dislodgement, and mechanical strain on the heart muscle. Additionally, batteries from these devices may need to be replaced every few years, necessitating further surgical procedures. Therefore, there is a critical need for novel pacemakers to address current complications and concerns, provide better patient comfort and compliance, and maintain or improve pacing.
Innovation:
UCLA researchers have developed a self-assembled implantable microtubular pacemaker that is lightweight and wireless, providing high electrical output and operational stability for intravascular myocardial pacing and mechanical coupling. This microtubular pacemaker is designed to reduce the mechanical burden due to device fixation to the myocardium and pacing lead-related medical complications. This innovative pacemaker utilizes a wireless radiofrequency module embedded in a flexible, thin printed circuit board (PCB) to receive power from an external source. The flexible PCB includes essential electrical components like capacitors and diodes. The electrodes on the PCB are coated with a thin layer of gold, providing stability in the body’s electrolyte environment. The PCB is then encapsulated with a protective layer, contributing to the stability of the microtube. The transmitter coil efficiently transfers power at a frequency of 1.0MHz, which minimizes radiation absorption by the body and enhances the strength of the magnetic field needed for effective power transfer. This pacemaker represents a significant advancement in medical technology, offering a safer, more reliable, and less invasive option for patients who need heart rhythm management.
Potential Applications:
• Cardiac Pacing for Patients with Arrythmias
• Temporary Pacing Post-Cardiac Surgery
• Heart Failure Management
• Research in Cardiac Electrophysiology
• Wearable Health Monitors
• Long-Term Implantable Biosensors
Advantages:
• Wireless Power Transfer reducing need for surgical interventions due to depleted batteries
• Lightweight and flexible design to reduce the mechanical burden and enhance patient comfort
• Reliable pacing
• Customizable manufacturing
Development-To-Date:
Initial conception of the invention was on 8/30/2021. Successful demonstrations of the invention were completed on 8/10/2023.
Related Papers and Patents:
1. Wang S., Cui, Q., et al. A self-assembled implantable microtubular pacemaker for wireless cardiac electrotherapy. Science Advances 2023. https://www.science.org/doi/10.1126/sciadv.adj0540
2. Cui, Q., Abiri, P., Cavallero, S., Tai, Y. C., & Hsiai, T. K. (2022). Abstract P2086: Wirelessly Powered Miniaturized Intravascular Pacemaker Based On Inductive Coupling. Circulation Research, 131(Suppl_1), AP2086-AP2086.
Reference:
UCLA Case No. 2024-059