Intro Sentence:
UCLA researchers from the Department of Surgery have developed a novel knotless suturing technique that functions similarly to a surgical-grade zip tie, offering a potentially transformative approach to wound closure.
Background:
Suturing remains a critical component of surgical wound closure across nearly all procedures, from open to minimally invasive techniques. Traditional suturing requires tying secure knots—an often technically demanding and time-consuming task, especially in confined or difficult-to-access surgical fields. This can lead to complications including knot failure, uneven tension, or increased suture bulk, which may impair healing or provoke immune responses.
While alternatives such as barbed sutures eliminate the need for knots, they typically require continuous placement and may not be suitable for all tissue types or procedures. High-tension closures may require additional reinforcement, adding procedural steps and complexity. Furthermore, even when new suturing technologies are available, adoption can be limited by clinician inertia and a preference for familiar techniques. There remains an unmet need for a versatile, knot-free suture that simplifies closure, improves consistency, and integrates easily into existing surgical workflows.
Innovation:
To address these challenges, UCLA researchers have developed a self-locking, knotless suture system—referred to as the "zip suture"—that enables single-point, adjustable tension closure using a zip-tie-like mechanism. The design incorporates:
- A serrated or beaded filament attached to a surgical needle
- An integrated low-profile locking component on the opposite end
- Adjustable tensioning by pulling the filament through the locking unit, preventing backsliding without the need for knot tying
This system is compatible with existing suture materials and tools, allowing for seamless integration into standard practice. Its simplicity may reduce operative time, enhance reproducibility across operator experience levels, and enable broader use in diverse surgical contexts. Variants of the design may be tailored for specific applications, including vascular and high-pressure tissue repairs, through lock geometry and material adjustments.
Potential Applications:
- General surgery wound closure
- Minimally invasive procedures
- Robotic-assisted surgery
- Plastic and reconstructive surgery
Advantages:
- Knot-free design
- Interrupted suture placement
- Self-locking
- Adjustable tension
- Compatible with a wide range of standard suture materials
- Adaptable to multiple lock designs
- Usable by trainees and experienced surgeons alike
Development-To-Date:
First description of complete invention (oral or written) 11/17/2023
Reference:
UCLA Case No. 2024-129
Lead Inventor:
Bryan Burt