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2022-178: CRISPR-MEDIATED DELETION OF FLI1 IN NK CELLS
SUMMARY: UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel method to increase the immune response of natural killer cells by ablating the transcriptional regulator Fli1 via CRISPR. BACKGROUND: Natural killer (NK) cells are innate immune cells that combat viral infections and serve as the...
Published: 9/5/2023
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Inventor(s):
Timothy O'Sullivan
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Gene Therapy And Editing
,
Therapeutics > Oncology > Oncology Immunotherapy
2021-056 CRISPR RIBONUCLEOPROTEIN COMPLEX GENOME EDITING OF HUMAN INNATE IMMUNE CELLS
Researchers in the Department of Microbiology, Immunology, and Molecular Genetics at UCLA have developed an optimized strategy for non-viral CRISPR-Cas9 ribonucleoprotein gene editing of primary innate immune cells. BACKGROUND:CRISPR (clustered, regularly interspaced, short palindromic repeats) genome engineering has become a powerful tool to investigate...
Published: 9/7/2023
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Inventor(s):
Timothy O'Sullivan
,
Luke Riggan
,
Andrew Hildreth
Keywords(s):
CRISPR
,
Gene Editing Systems
Category(s):
Therapeutics > Gene Therapy And Editing