Search Results - elaine+hsiao

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Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic Diet (UCLA Case No. 2025-006)

UCLA researchers from the Department of Integrative Biology & Physiology have identified specific components of ketogenic diets that alter the microbiome and improve seizure resistance, providing valuable data to optimize diet treatments for refractory epilepsy. BACKGROUND: Refractory epilepsy, a disease characterized by uncontrolled seizures,...

Published: 9/19/2024 | Inventor(s): Elaine Hsiao

Keywords(s): diet, dietary fiber, Epilepsy, gut, gut-brain axis, ketogenic diet, microbiome, pediatrics, seizure

Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology

2019-341: Microbiome-Based Regulation of Cognitive Behavior

UCLA researchers in the Department of Integrative Biology & Physiology have discovered select bacterial factors that can be targeted to promote hippocampal functions and cognitive behaviors. BACKGROUND: Cognitive impairment, characterized by deficient attention, causal reasoning, and learning and memory, is a pressing public health concern, afflicting...

Published: 7/19/2023 | Inventor(s): Elaine Hsiao

Keywords(s): Cns, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology

2019-519 MICROBIOME-BASED MODULATION OF SENSORY NEURONAL ACTIVITY

UCLA researchers in the Department of Integrative Biology and Physiology have begun to elucidate the molecular pathways for communication between the gut microbiota and the brain, serving as potential therapeutic targets for the treatment of various neurological diseases.BACKGROUND: The gut microbiota is recognized as an important regulator of brain...

Published: 7/16/2024 | Inventor(s): Elaine Hsiao

Keywords(s): Diagnostic Markers & Platforms, Gastroenterology & Digestive Disease

Category(s): Therapeutics > Gastroenterology

2019-520 MATERNAL GUT MICROBIOTA REGULATION OF NEURODEVELOPMENT AND ADULT SENSORY BEHAVIOR

UCLA Researchers in the Department of Integrative Biology and Physiology have determined the necessary role for maternal gut microbes in neurodevelopment and that select microbes may prevent abnormal neurodevelopmental phenotypes.BACKGROUND: The gastrointestinal tract and brain are intimately linked, and in the past decade there have been increasing...

Published: 2/16/2024 | Inventor(s): Elaine Hsiao, Helen Vuong

Keywords(s): Diagnostic Markers & Platforms, Gastroenterology & Digestive Disease

Category(s): Therapeutics > Gastroenterology

2019-531 MICROBIOME-BASED INTERVENTION FOR INTRAUTERINE GROWTH RESTRICTION

SummaryUCLA researchers in the Department of Integrative Biology and Physiology have identified one of the underlying causes of intrauterine growth restriction, which may be treated with microbiome-based therapeutics.BackgroundIntrauterine growth restriction (IUGR), defined as failure to maintain expected utero growth potential due to genetic or environmental...

Published: 7/19/2023 | Inventor(s): Elaine Hsiao

Keywords(s): Therapeutics & Vaccines

Category(s): Therapeutics

2019-004 METHODS TO REGULATE COLONIZATION OF SELECT BACTERIA OF THE MICROBIOME / MICROBE-BASED MODULATION OF LIPID AND STEROID METABOLISM

SummaryUCLA researchers in the Department of Integrative Biology and Physiology have identified a novel function of serotonin in regulating colonization of select bacterial species in the gut microbiome, and have identified specific bacteria that may modulate host intestinal lipid and steroid metabolism.BackgroundSerotonin, or 5-hydroxytryptamine (5-HT)...

Published: 7/19/2023 | Inventor(s): Elaine Hsiao

Keywords(s): Gastroenterology & Digestive Disease, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Gastroenterology