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Impaired Nucleotide Catabolism Renders Cancer Cells Sensitive to PNP Inhibition

UCLA researchers in the Department of Molecular and Medical Pharmacology have uncovered novel biomarkers to predict cancer sensitivity to PNP inhibitors. BACKGROUND: A common hallmark of cancer is the alteration of cellular metabolism. To sustain growth and proliferation, cancer cells must produce sufficient and balanced pools of deoxyribonucleotide...

Published: 7/19/2023 | Inventor(s): Caius Radu, Evan Abt, Thuc Le

Keywords(s): Oncology (Small Molecules, Peptides and Antibodies)

Category(s): Therapeutics > Oncology > Oncology (Small Molecules)