INTRO SENTENCE:
UCLA researchers have developed a novel bone cement material for the treatment of osteoporotic fractures and degenerative joint disorders.
BACKGROUND:
Bone cement is a critical component of various types of orthopedic surgery that is used as spacers and for fixation of implants. Bone cement can be loaded with antibiotics to help with the treatment of infections and can act as a shock absorber to ensure transfer of load from the implant to the bone. The composition of bone cement is a crucial element to the success of the transplantation due to the risk of “cement disease”, which is characterized by the formation of necrotic and fibrous tissue. “Cement disease” can be caused by cytotoxic materials that promote cell death, ultimately causing failure of the prostheses. In addition to considering the cytotoxicity of bone cement, another important element of bone cement is how it can stimulate the osteogenic response. Incompatible materials can suppress osteoblasts, inhibiting bone growth, therefore stunting recovery. In consideration of these factors, development of non-cytotoxic, biocompatible bone cement is a necessary step to improve orthopedic surgical outcomes.
INNOVATION:
UCLA researchers have developed a novel bone cement material that is non-cytotoxic and osteoconductive, which improves compatibility of this substance with the body. The component added has been established to be safe as a health supplement.
POTENTIAL APPLICATIONS:
• Fixation of orthopedic implants
• Bone cement spacers
• Stabilizing dental implants
ADVANTAGES:
• Non-cytotoxic, reducing formation of fibrosis and necrotic tissue
• Osteoconductive to promote osteoblast function