SUMMARY: UCLA Researchers in the Departments of Bioengineering and Pediatrics have developed a tool for efficient toxicology tests of electronic cigarette products. BACKGROUND: The use of electronic cigarettes (e-cigarettes) has been increasing since 2011, especially amongst American youths. Pediatricians and other healthcare providers are increasingly concerned that these products (and the way that they are aggressively marketed) pose a tremendous danger to children’s health. In 2020, 3.6 million adolescents and young adults reported regular use of e-cigarette and vaping devices, but the true effects of these new and emerging tobacco products (and all the chemicals they contain) are not known. Among high school users, almost 40% are using e-cigarettes more than 20 days a month, and more than 8 out of 10 report use of flavored products. E-cigarettes often contain ingredients such as propylene glycol and glycerol, mixed with concentrated flavors and, optionally, a variable percentage of nicotine. Some of the compounds found in the solution and aerosols generated by e-cigarettes are known to be toxic, carcinogenic, and/or to cause respiratory and cardiac diseases. There are more than 15,000 unique flavors on the market, and the chemical compositions are highly variable, yet current testing tools can only test one aerosol at a time. Therefore, there is an increasing need to develop new research tools that enable efficient, systematic, and combinatorial toxicology testing strategies for e-cigarette and vaping products that can help to guide regulatory efforts in support of public health initiatives focused on this critical area of children’s health. INNOVATION: UCLA Researchers in the Departments of Bioengineering and Pediatrics have developed a new tool for testing e-cigarette aerosols more efficiently. The device, called CloudEAD (Even Aerosol Distribution), can simultaneously test up to 6 unique aerosols with no cross-contamination therefore increasing the testing efficiency by six-fold. The device can be produced by 3D printing, and the cost is roughly $100, making it more affordable and cost-effective than currently available devices on the market. This invention therefore addresses the increasing need for high throughput solutions to test and inform the regulation of the rapidly expanding landscape of e-cigarette products. POTENTIAL APPLICATIONS: ● Tests and screening of e-cigarettes and other noncombustible tobacco products ADVANTAGES: ● high throughput, testing up to 6 unique aerosols at the same time ● more cost-effective and less time consuming DEVELOPMENT-TO-DATE: A prototype has been developed and validated.