UCLA researchers in Department of Medicine, Division of Cardiology have identified the protective effects of gut-heart crosstalk mediated by 3-propionic acid (IPA) in the progression of heart failure with preserved ejection fraction (HFpEF). IPA supplementation could rescue the IPA deficiency associated heart defects, protect against heart malfunction, and serve as a treatment for HFpEF.
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Related papers (from the inventors only): Wang YC, Koay YC, Pan C, Zhou Z, Tang W, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y, Lusis AJ. Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction. Circ Res. 2024 Feb 16;134(4):371-389. doi: 10.1161/CIRCRESAHA.123.322381. Epub 2024 Jan 24. PMID: 38264909; PMCID: PMC10923103.
Keywords: 3-propionic acid, IPA, heart failure with preserved ejection fraction, HFpEF, Clostridium sporogenes, nicotinamide, NAD+/NADH, gut microbiota dysbiosis, diastolic dysfunction