Search Results - aldons+lusis

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Indole-3-Propionic Acid (IPA) Protects Against Heart Failure with Preserved Ejection Fraction (HFpEF) (UCLA Case No. 2022-142)

UCLA researchers in the Department of Medicine, Division of Cardiology have identified the protective effects of gut-heart crosstalk mediated by 3-propionic acid (IPA) in the progression of heart failure with preserved ejection fraction (HFpEF). IPA supplementation could rescue the IPA deficiency associated heart defects, protect against heart malfunction,...

Published: 2/26/2026 | Inventor(s): Aldons Lusis, Yang Cao

Keywords(s):

Category(s): Therapeutics > Cardiovascular, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Metabolism And Endocrinology

Coagulation Factor XI (FXI) Functional Roles and Regulation for Treatment of Heart Failure (UCLA Case No. 2022-141)

UCLA researchers from the Department of Medicine have discovered a novel therapeutic target to treat heart failure with preserved ejection fraction (HFpEF), which afflicts approximately half of all patients with heart failure. BACKGROUND: Heart failure is one of the leading causes of death and disease with over 500,000 cases diagnosed each year in...

Published: 2/26/2026 | Inventor(s): Aldons Lusis, Yang Cao

Keywords(s):

Category(s): Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology

2016-876 DEVELOPMENT OF A METHOD FOR ENDOCRINE NETWORK DISCOVERY UNCOVERS PEPTIDE THERAPEUTIC TARGETS

Development Of A Method For Endocrine Network Discovery Uncovers Peptide Therapeutic TargetsSUMMARYUCLA researchers in the Division of Cardiology at the Geffen School of Medicine have developed a bioinformatics methodology to identify and functionally annotate novel endocrine pathways.BACKGROUNDBeginning with the discovery of insulin, endocrine tissue...

Published: 2/14/2025 | Inventor(s): Aldons Lusis, Marcus Seldin

Keywords(s): Life Science Research Tools, Software

Category(s): Life Science Research Tools, Software & Algorithms > Programs

2014-730 AGPAT5 as a Molecular Mediator of Insulin Resistance

AGPAT5 as a Molecular Mediator of Insulin ResistanceSUMMARYUCLA researchers in the Departments of Medicine and Cardiology have identified a novel gene and pathway in the regulation of insulin sensitivity and discovered an inhibitor of this gene useful for treating AGPAT5-related diseases.BACKGROUNDInsulin resistance (IR), a condition in which the body’s...

Published: 7/17/2025 | Inventor(s): Aldons Lusis, Brian Parks, Richard Lee

Keywords(s): Cardiovascular, Diagnostic Markers & Platforms, Metabolic Diseases, Therapeutics & Vaccines

Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology