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2022-129 Development of Nano-Delivered CXCR4 Antagonist Carrier to Affect Tumor Microenvironment

SUMMARY: UCLA researchers in the David Geffen School of Medicine have developed a nanocarrier platform to deliver drugs that block CXCR4 directly in tumor microenvironments, with an impact on immune cell trafficking and reducing the tumor’s metastatic burden. BACKGROUND: Cancer remains among the leading causes of death worldwide, and its burden...

Published: 2/5/2024 | Inventor(s): Andre Nel

Keywords(s):

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy

2022-017: Single and Multi-Epitope Peptide and mRNA Vaccines to Generate Tolerogenic Effects for Allergic and Autoimmune Disease by Targeting Liver Sinusoidal Endothelial Cells

SUMMARY: UCLA researchers in the School of Medicine and California NanoSystems Institute have developed a novel treatment method utilizing intravenously-delivered nanoparticles loaded with epitopes that interfere with the anaphylaxis response for sustained tolerance to food allergens. BACKGROUND: The U.S. Food and Drug Administration (FDA) defines...

Published: 9/5/2023 | Inventor(s): Andre Nel

Keywords(s):

Category(s): Therapeutics, Therapeutics > Autoimmune, Therapeutics > Vaccines

2022-165 Development of a Silicasome Drug Nanocarrier System to Deliver a Lipid Bilayer-Encapsulated TLR7 Agonist for Cancer Immunotherapy

SUMMARY: UCLA researchers in the Department of Medicine have developed a scalable and injectable drug delivery platform that allows for tumor-specific combinatorial cancer immunotherapy treatment of pancreatic cancer. BACKGROUND: The National Institute of Health reports that pancreatic ductal adenocarcinomas (PDAC) accounts for at least 90% of all...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nanoparticles, Therapeutics > Oncology

2022-085: MULTI-EPITOPE MRNA SARS-COV-2 VACCINE FOR BOOSTING IMMUNITY THROUGH THE ACTIVATION OF CD4 AND CD8 T CELLS AS WELL AS B LYMPHOCYTES

SUMMARY: UCLA Researchers in the Division of Nanomedicine and Microbiology, Immunology and Molecular Genetics have developed a new SARS-CoV-2 vaccine that provides long lasting and robust immunity. BACKGROUND: An effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constitutes a major global health priority. While multiple...

Published: 11/15/2024 | Inventor(s): Andre Nel, Tian Xia, Jeffery Miller

Keywords(s):

Category(s): Therapeutics, Therapeutics > Infectious Diseases, Therapeutics > Vaccines, Therapeutics > Infectious Diseases > COVID

2021-001 COMBINATION CHEMO-IMMUNOTHERAPY FOR PANCREATIC CANCER USING THE IMMUNOGENIC EFFECTS OF AN IRINOTECAN SILICASOME NANOCARRIER PLUS ANTI-PD-1

SUMMARYUCLA researchers in the Department of Medicine have developed a combination therapy for pancreatic cancers using the irinotecan Silicasome nanocarrier and an anti-PD-1 antibody.BACKGROUND: Immune checkpoint inhibitors (ICIs) has shown promising therapeutic effects for the treatment of cancers such as renal and lung cancer. However, there has...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nanoparticles

2021-005 Liver-Targeting Tolerogenic Nanoparticles Encapsulating an Allergen T-Cell Epitope Impacts Eosinophilic Airway Inflammation with Comparable Efficacy as Pharmaceutical Tolerogenic Nanoparticles

UCLA researchers in the David Geffen School of Medicine and CNSI have developed a nanoparticle that induces antigen tolerance for use in treatment of allergy and autoimmune diseases. BACKGROUND: When the body’s immune overreacts against environmental allergens or falsely recognizes the body’s own molecular components as foreign, the results...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s): Autoimmune, Drug Delivery, Materials, Nanoparticles, Nanotechnology

Category(s): Materials > Nanotechnology, Therapeutics > Autoimmune, Therapeutics > Inflammation And Inflammatory Diseases

2020-784 DEVELOPMENT OF A STING DELIVERING NANOPARTICLE FOR IMMUNOTHERAPY OF CANCER METASTASES TO THE LIVER

UCLA researchers in the Department of Nanomedicine have developed antigen presenting cells (APCs) targeting nanoparticles to deliver STING (stimulator of interferon genes) agonists to the liver for metastatic cancer treatment. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and estimated to become the second leading...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s): Drug Delivery, Immunotherapy, Nanoparticles, Oncology, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Nanoparticles, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Materials > Nanotechnology

2017-176 DEVELOPMENT OF SURFACE ENHANCED GRAPHENE OXIDE FOR UBIQUITOUS ANTIBACTERIAL COATINGS

SummaryUCLA researchers in the Department of Medicine have developed a novel graphene oxide (GO) based material with significantly enhanced antibacterial effects with maximized surface display of carbon radicals.BackgroundAdhesion of bacteria to surfaces of human tissue, biomaterials and medical devices significantly increases the risk of infection...

Published: 7/19/2023 | Inventor(s): Andre Nel, Tian Xia, Ruibin Li, Mark Hersam, Nikhita Mansukhani, Linda Guiney

Keywords(s): General Device Coatings, Medical Devices and Materials

Category(s): Medical Devices, Medical Devices > Coatings