Search Results - therapeutics

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Compound Drug Delivery System (Case No. 2024-015)

Summary: Researchers in UCLA’s Department of Orthopaedic Surgery have developed novel multi-drug delivery system that is compatible with standard syringe-based administration routes. Background: Drug compounding is the process of combining two or more medications to meet the needs of individual patients. Surgeons may mix different anesthetics...

Published: 9/11/2024 | Inventor(s): Fabrizio Billi, Mauricio Silva, Aaron Kavanaugh

Keywords(s):

Category(s): Therapeutics, Platforms, Platforms > Drug Delivery, Medical Devices

Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)

Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...

Published: 9/11/2024 | Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman

Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy

Surgical Mesh Permanent Implant (Case No. 2023-109)

Summary: UCLA Researchers in the Department of Chemistry and Biochemistry have developed a bacterial nanocellulose (BNC) that exhibits promising biocompatibility and mechanical properties that can be used as a long-term treatment for medical conditions requiring surgical mesh devices. Background: Surgical mesh devices are medical devices used to...

Published: 10/7/2024 | Inventor(s): Paul Weiss, Melina Mastrodimos, Maryam Badv

Keywords(s): Biologic Medical Product, Biomedical Engineering, biomedical implantation, Implant (Medicine), Medical Device, Medical Devices and Materials, Orthopedics and Prosthetics (O & P), Prosthesis, Prosthetics, Smart medical device, Surgical Instrument, surgical mesh, Surgical Tools, wearable medical device

Category(s): Medical Devices, Medical Devices > Surgical Tools, Materials, Materials > Functional Materials, Therapeutics, Therapeutics > Gastroenterology, Therapeutics > Urology, Therapeutics > Transplant

Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)

Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...

Published: 8/15/2024 | Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton

Keywords(s):

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment

Zeolite Imidazole Framework-8 (Zif-8)-Based Osteoinductive and Inflammation-Inhibitory Coating for Dental Implants (Case No. 2023-141)

Summary: UCLA researchers from the School of Dentistry have developed zeolitic imidazolate framework-8 (ZIF-8) nanoparticles-based implant coating system for the controlled release of therapeutics. Background: One of the most significant advancements in clinical dentistry over the past four decades is the development of osteointegrated dental implants....

Published: 9/9/2024 | Inventor(s): Alireza Moshaverinia, Weihao Yuan

Keywords(s):

Category(s): Therapeutics, Therapeutics > Dental, Medical Devices, Medical Devices > Coatings, Medical Devices > Surgical Tools, Materials

Portable, Lanyard Attachable Pill Popper Gadget (Case No. 2022-238)

Summary: UCLA researchers from the Department of Orthopedic Surgery have developed a portable gadget for handling medical packaging in the healthcare space. Background: Healthcare workers operate in a dynamic environment where they use a variety of medical supplies including gauze pads, pills, and face masks. Disposable supplies can be packaged...

Published: 10/16/2024 | Inventor(s): Veronica Pellegrino

Keywords(s):

Category(s): Medical Devices, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > Medication, Materials, Materials > Functional Materials

Inhibitory Chimeric Antigen Receptors That Reduce Car-T Cell “On-Target, Off-Tumor” Toxicity (UCLA Case No. 2022-186)

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics, and the Department of Molecular and Medical Pharmacology have recently developed a novel approach which improves the kinetics and specificity of CAR T-cell therapy. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered...

Published: 5/16/2024 | Inventor(s): Owen Witte

Keywords(s): blood cancers, CAR-T cell therapy

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics

Use of Dupilumab for Disseminated Fungal Infection (UCLA Case No. 2019-706)

BACKGROUND: Dupilumab, an immunomodulatory drug that blocks IL-4 signaling, is most commonly used to treat moderate-to-severe atopic dermatitis (a form of eczema) and asthma in both adults and adolescents. While fungal infections, such as coccidioidomycosis, can be potentially treated with immunomodulatory drugs, Dupilumab does not currently have...

Published: 5/14/2024 | Inventor(s): Manish Butte, Maria Garcia-Lloret

Keywords(s): Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Infectious Diseases

Preparation of Hexahydrocannabinol (HHC) (Case No. 2023-172)

Summary: UCLA researchers in the Department of Chemistry & Biochemistry have developed a novel method to produce hexahydrocannabinols, which are derivatives of THC, the psychoactive component of cannabis. Background: As the cannabis industry evolves with changing legal and societal opinions, derivatives of the psychoactive components of marijuana,...

Published: 5/30/2024 | Inventor(s): Neil Garg, Daniel Nasrallah

Keywords(s): cannabinoid, cannabis, catalytic hydrogenation, delta 8, delta 9, diastereomer, enantioenriched, enantiospecific, hexahydrocannabinol, hexahydrocannabinols (HHC), hydrogen atom transfer, hydrogenation, marijuana, Nutraceuticals, Recreational cannabis products, tetrahydrocannabinol, THC

Category(s): Chemical, Chemical > Synthesis, Chemical > Emulsions, Therapeutics, Therapeutics > Oncology

A Wearable On-Eyelid Sensor Network for Vestibular-Ocular Reflex Assessment (Case No. 2023-166)

Summary: UCLA researchers in the Department of Bioengineering have developed an ultra-thin, self-powered, waterproof, biocompatible, and sensitive on-eyelid sensor network for wireless eye movement detection, enhancing vestibular diagnostics. Background: The human balance system relies on the interaction of the vestibular system with the visual and...

Published: 4/19/2024 | Inventor(s): Jun Chen, Jing Xu

Keywords(s): diseases of the eye, eye motion, eye movement disorders, eye tracking, gaze fixation, magnetoelastic effect, magnetoelastic sensor, on-eyelid sensor, peripheral vestibular disorders, vestibular pathology assessment, Vestibular-Ocular Reflex (VOR)

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics, Electrical, Electrical > Signal Processing, Electrical > Sensors

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