Search Results - therapeutics

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Broad-Band Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Neuropsychiatric Disorders (Case No. 2025-99J)

Summary: Researchers in UCLA's Semel Institute and Department of Psychiatry have developed an innovative approach to treating depression by optimizing repetitive Transcranial Magnetic Stimulation (rTMS), improving its effectiveness for the treatment of Major Depressive Disorder (MDD) and possibly diseases of the mind and brain. Background: Depression...

Published: 10/16/2025 | Inventor(s): Andrew Leuchter, Juliana Corlier, Thomas Valles

Keywords(s): Bioelectromagnetics, Brain, Deep Brain Stimulation, Electrical Brain Stimulation, energy-efficient, frequency modulation, Magnetic Field, Medical Device, medication efficacy, neural information, neural network, neural networks, neural signals, neural stimulation, neurobehavioral impairment, Neurocognitive, neurological disorders, Neuromodulation, Neuron, neurons, neuroscience, Neurostimulation, pulsed load modulation, therapy, treatment efficacy

Category(s): Medical Devices, Medical Devices > Neural Stimulation, Life Science Research Tools, Therapeutics > CNS and Neurology, Therapeutics

Balloon Catheter for Thermal Ablation Protection (Case No. 2024-210)

Summary UCLA researchers have developed a novel planar balloon catheter that reliably separates and protects organs during thermal ablation procedures. By creating a sheet-like thermal barrier, the device mitigates unintended injury to nearby healthy tissues—particularly the stomach and bowel—thereby enabling safer and more effective treatment...

Published: 9/26/2025 | Inventor(s): David Lu

Keywords(s): catheter, Catheterization, Swan-Ganz catheter

Category(s): Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Oncology, Therapeutics > Renal, Therapeutics

Self-Amplifying RNA Form of a Constitutively-Active Sting Protein for Enhancing T-Cell Response to Antigen-Presenting Cells (UCLA Case No. 2020-771)

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for delivering RNA to induce an immune response to cancer cells. BACKGROUND: Cancer therapy continues to remain a challenge despite improvements in detection and clinically available therapies. Recently, improvements to this field have been mainly in the...

Published: 10/22/2025 | Inventor(s): William Gelbart

Keywords(s): Adenoviridae

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Diagnostic Markers > Targets And Assays

Self-Powered Electrical Stimulation Magnetoelastic Bandage for Accelerated Wound Healing (Case No. 2025-99N)

Reference: UCLA Case No. 2025-99N Please reach out to our office for more information.

Published: 10/10/2025 | Inventor(s): Jun Chen, Kanishk Rai, Song Li, Il Woo Ock, Haochen Nan

Keywords(s):

Category(s): Therapeutics, Therapeutics > Aesthetic Medicine, Materials, Materials > Functional Materials, Materials > Membranes, Electrical, Electrical > Flexible Electronics

Bioelectric Neuromodulation Methods for Hematopoiesis Regulation During Chemotherapy (Case No. 2020-382)

Summary: UCLA researchers in the Department of Bioengineering have developed an electrical neuromodulation method to accelerate recovery from deleterious chemotherapy side effects to improve patient outcome. Background: Chemotherapy works by targeting and killing fast-growing cancer cells using anti-cancer drugs. However, because these drugs lack...

Published: 10/21/2025 | Inventor(s): Wentai Liu

Keywords(s): algorithmic cancer detection, Bladder Cancer, blood cancers, Brain cancer, Breast Cancer, Cancer, cancer antigen, cancer detection, Cancer Immunotherapy, cancer inhibition, cancer metabolism, Cancer stem cells, cancer target, castration resistant prostate cancer, Chemotherapy, head and neck cancer, lympathic cancers, lymphatic cancer, Mesenchymal Stem Cell Derived Cancer Cells, Neuromodulation, non-small cell lung cancer, Orthotopic cancer models, Pancreatic cancer, prostate cancer, small cell cancer, small cell lung cancer, small cell prostate cancer

Category(s): Medical Devices, Medical Devices > Neural Stimulation, Chemical, Electrical, Therapeutics, Therapeutics > Oncology

Methods and Systems for Low-Cost Medical Image Annotation Using Non-experts (Case No. 2025-108)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an AI-based interface designed to enable individuals without specialized training to identify arthritis in medical imaging. Background: The use of artificial intelligence (AI) for medical imaging analysis holds great promise for the future of healthcare....

Published: 11/6/2025 | Inventor(s): Xiang Chen, Youngseung Jeon, Christopher Hwang

Keywords(s): 3D tissue imaging, AI-guided diagnostics, AI-guided medical imaging, AI-guided medical intervention, arthritis, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, Artificial Neural Network, bioimaging, Computer-Aided Diagnosis, computer-aided radiology, Diagnostic Markers & Platforms, Diagnostic Test, diagnostics, generative artificial intelligence, Image Analysis, Image Resolution, Imaging, infrared thermal imaging, Machine Learning, machine learning modeling, machine perception, Magnetic Resonance Imaging Medical Physics, Magnetic Resonance Imaging Pathology, Medical artificial intelligence (AI), Medical diagnostics, Medical Imaging, Microscopy And Imaging, non-invasive imaging, osteoarthritis, radial MRI, radiologic imaging, Radiology, Radiology / Radiomitigation, radiosurgery

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > Musculoskeletal Disease, Therapeutics > Radiology

Mechanical Cutaneous Nerve Stimulation for Reducing Epileptic Seizures and Perceived Pain (Case No. 2016-686-3)

Summary: UCLA researchers have developed a novel, non-invasive pain management device that uses mechanical vibrations to activate cutaneous sensory fibers, reducing epileptic seizures, masking pain perception and alleviating associated symptoms. Background: Unexpected death due to epilepsy is a pressing concern, with an estimated incidence of 1.2...

Published: 7/29/2025 | Inventor(s): Ronald Harper, Eberhardt Sauerland, Christopher Degiorgio

Keywords(s): low-power device, Medical Device, Medical Devices and Materials, minimally invasive device, Neuropathology, Neurostimulation, non-invasive, Pain Treatment, sample-to-answer devices, Semiconductor Device, Smart medical device, Stroke, Transcutaneous Electrical Nerve Stimulation, Vibration monitoring, Vibration sensing, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Neural Stimulation, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > CNS and Neurology

A Ventilated Artificial Human Lung Exposure System to Analyze and Test Human Exposures to Inhaled Substances (Case No. 2023-306)

Summary: UCLA researchers in the Department of Medicine and Environmental Health Sciences have developed a ventilated human lung system for laboratory testing of inhaled substances. Background: Measuring the toxicology of inhaled air, aerosols and other substances is challenging due to the complexity of human studies and limitations in existing...

Published: 7/28/2025 | Inventor(s): Michael Roth, Airi Harui, Yifang Zhu, Haoxuan Chen

Keywords(s): aerosol, Angiogenesis Acute Lung Injury, bioaerosol, cardiopulmonary illness, Cellular Respiration, consumer goods and products, Lung, Lung Pulmonology, non-small cell lung cancer, Preclinical model development, Preclinical surgical innovation, pulmonary arterial pressure (PAP), pulmonary failure, Pulmonary fibrosis, Respiratory & Pulmonary, respiratory failure, right atrial to pulmonary canula, Simulation & Modeling, simulation model, small cell lung cancer

Category(s): Platforms, Platforms > Drug Delivery, Life Science Research Tools, Life Science Research Tools > Research Methods, Therapeutics, Therapeutics > Respiratory And Pulmonary, Mechanical, Mechanical > Sensors

Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing (Case No. 2025-128)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a novel, high-sensitivity chemiluminescence vertical flow assay for rapid cardiac diagnostics, addressing current challenges in both modern and underserved healthcare settings. Background: Point-of-care (POC) testing is performed...

Published: 10/17/2025 | Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo, Merve Eryilmaz

Keywords(s):

Category(s): Chemical, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Electrical > Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Therapeutics, Therapeutics > Cardiovascular

Material for Enhanced Photoprotection (Case No. 2025-050)

Summary: UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel material for enhanced photoprotection in sunscreens. Background: Exposure to ultraviolet (UV) radiation from the sun contributes to premature skin aging, sunburn, and increased risk of skin cancer. Traditional UV filters such as zinc oxide and titanium...

Published: 8/21/2025 | Inventor(s): Paul Weiss, Ajoa Addae, Yogendra Mishra

Keywords(s): antimicrobial, antiviral, caprylic/capric triglyceride, cosmetic ingredients, dispersion stability, emulsions, flame transport synthesis, Material for Enhanced Photoprotection, Nanocrystal, nanocrystalline metals, nanodispersion, Photodetector, photostability, photostability materials, photothermal materials, skin protection, sunscreen, sunscreen formulation, tocopheryl acetate, UV absorption

Category(s): Materials, Materials > Functional Materials, Therapeutics, Therapeutics > Dermatology

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