Search Results - therapeutics

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Bioelectric Neuromodulation Methods for Hematopoiesis Regulation During Chemotherapy (Case No. 2020-382)

Summary: UCLA researchers in the Department of Bioengineering have developed an electrical neuromodulation method to accelerate recovery from deleterious chemotherapy side effects to improve patient outcome. Background: Chemotherapy works by targeting and killing fast-growing cancer cells using anti-cancer drugs. However, because these drugs lack...

Published: 8/21/2025 | Inventor(s): Wentai Liu

Keywords(s): algorithmic cancer detection, Bladder Cancer, blood cancers, Brain cancer, Breast Cancer, Cancer, cancer antigen, cancer detection, Cancer Immunotherapy, cancer inhibition, cancer metabolism, Cancer stem cells, cancer target, castration resistant prostate cancer, Chemotherapy, head and neck cancer, lympathic cancers, lymphatic cancer, Mesenchymal Stem Cell Derived Cancer Cells, Neuromodulation, non-small cell lung cancer, Orthotopic cancer models, Pancreatic cancer, prostate cancer, small cell cancer, small cell lung cancer, small cell prostate cancer

Category(s): Medical Devices, Medical Devices > Neural Stimulation, Chemical, Electrical, Therapeutics, Therapeutics > Oncology

Methods and Systems for Low-Cost Medical Image Annotation Using Non-experts (Case No. 2025-108)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an AI-based interface designed to enable individuals without specialized training to identify arthritis in medical imaging. Background: The use of artificial intelligence (AI) for medical imaging analysis holds great promise for the future of healthcare....

Published: 7/23/2025 | Inventor(s): Xiang Chen, Youngseung Jeon, Christopher Hwang

Keywords(s): 3D tissue imaging, AI-guided diagnostics, AI-guided medical imaging, AI-guided medical intervention, arthritis, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, Artificial Neural Network, bioimaging, Computer-Aided Diagnosis, computer-aided radiology, Diagnostic Markers & Platforms, Diagnostic Test, diagnostics, generative artificial intelligence, Image Analysis, Image Resolution, Imaging, infrared thermal imaging, Machine Learning, machine learning modeling, machine perception, Magnetic Resonance Imaging Medical Physics, Magnetic Resonance Imaging Pathology, Medical artificial intelligence (AI), Medical diagnostics, Medical Imaging, Microscopy And Imaging, non-invasive imaging, osteoarthritis, radial MRI, radiologic imaging, Radiology, Radiology / Radiomitigation, radiosurgery

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > Musculoskeletal Disease, Therapeutics > Radiology

Mechanical Cutaneous Nerve Stimulation for Reducing Epileptic Seizures and Perceived Pain (Case No. 2016-686-3)

Summary: UCLA researchers have developed a novel, non-invasive pain management device that uses mechanical vibrations to activate cutaneous sensory fibers, reducing epileptic seizures, masking pain perception and alleviating associated symptoms. Background: Unexpected death due to epilepsy is a pressing concern, with an estimated incidence of 1.2...

Published: 7/29/2025 | Inventor(s): Ronald Harper, Eberhardt Sauerland, Christopher Degiorgio

Keywords(s): low-power device, Medical Device, Medical Devices and Materials, minimally invasive device, Neuropathology, Neurostimulation, non-invasive, Pain Treatment, sample-to-answer devices, Semiconductor Device, Smart medical device, Stroke, Transcutaneous Electrical Nerve Stimulation, Vibration monitoring, Vibration sensing, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Neural Stimulation, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > CNS and Neurology

A Ventilated Artificial Human Lung Exposure System to Analyze and Test Human Exposures to Inhaled Substances (Case No. 2023-306)

Summary: UCLA researchers in the Department of Medicine and Environmental Health Sciences have developed a ventilated human lung system for laboratory testing of inhaled substances. Background: Measuring the toxicology of inhaled air, aerosols and other substances is challenging due to the complexity of human studies and limitations in existing...

Published: 7/28/2025 | Inventor(s): Michael Roth, Airi Harui, Yifang Zhu, Haoxuan Chen

Keywords(s): aerosol, Angiogenesis Acute Lung Injury, bioaerosol, cardiopulmonary illness, Cellular Respiration, consumer goods and products, Lung, Lung Pulmonology, non-small cell lung cancer, Preclinical model development, Preclinical surgical innovation, pulmonary arterial pressure (PAP), pulmonary failure, Pulmonary fibrosis, Respiratory & Pulmonary, respiratory failure, right atrial to pulmonary canula, Simulation & Modeling, simulation model, small cell lung cancer

Category(s): Platforms, Platforms > Drug Delivery, Life Science Research Tools, Life Science Research Tools > Research Methods, Therapeutics, Therapeutics > Respiratory And Pulmonary, Mechanical, Mechanical > Sensors

Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing (Case No. 2025-128)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a novel, high-sensitivity chemiluminescence vertical flow assay for rapid cardiac diagnostics, addressing current challenges in both modern and underserved healthcare settings. Background: Point-of-care (POC) testing is performed...

Published: 6/13/2025 | Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo, Merve Eryilmaz

Keywords(s):

Category(s): Chemical, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Electrical > Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Therapeutics, Therapeutics > Cardiovascular

Material for Enhanced Photoprotection (Case No. 2025-050)

Summary: UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel material for enhanced photoprotection in sunscreens. Background: Exposure to ultraviolet (UV) radiation from the sun contributes to premature skin aging, sunburn, and increased risk of skin cancer. Traditional UV filters such as zinc oxide and titanium...

Published: 8/21/2025 | Inventor(s): Paul Weiss, Ajoa Addae, Yogendra Mishra

Keywords(s): antimicrobial, antiviral, caprylic/capric triglyceride, cosmetic ingredients, dispersion stability, emulsions, flame transport synthesis, Material for Enhanced Photoprotection, Nanocrystal, nanocrystalline metals, nanodispersion, Photodetector, photostability, photostability materials, photothermal materials, skin protection, sunscreen, sunscreen formulation, tocopheryl acetate, UV absorption

Category(s): Materials, Materials > Functional Materials, Therapeutics, Therapeutics > Dermatology

Compound Drug Delivery System (Case No. 2024-015)

Summary: Researchers in UCLA’s Department of Orthopaedic Surgery have developed novel multi-drug delivery system that is compatible with standard syringe-based administration routes. Background: Drug compounding is the process of combining two or more medications to meet the needs of individual patients. Surgeons may mix different anesthetics...

Published: 8/21/2025 | Inventor(s): Fabrizio Billi, Mauricio Silva, Aaron Kavanaugh

Keywords(s):

Category(s): Therapeutics, Platforms, Platforms > Drug Delivery, Medical Devices

Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)

Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...

Published: 3/3/2025 | Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman

Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy

Surgical Mesh Permanent Implant (Case No. 2023-109)

Summary: UCLA Researchers in the Department of Chemistry and Biochemistry have developed a bacterial nanocellulose (BNC) that exhibits promising biocompatibility and mechanical properties that can be used as a long-term treatment for medical conditions requiring surgical mesh devices. Background: Surgical mesh devices are medical devices used to...

Published: 2/14/2025 | Inventor(s): Paul Weiss, Melina Mastrodimos, Maryam Badv

Keywords(s): Biologic Medical Product, Biomedical Engineering, biomedical implantation, Implant (Medicine), Medical Device, Medical Devices and Materials, Orthopedics and Prosthetics (O & P), Prosthesis, Prosthetics, Smart medical device, Surgical Instrument, surgical mesh, Surgical Tools, wearable medical device

Category(s): Medical Devices, Medical Devices > Surgical Tools, Materials, Materials > Functional Materials, Therapeutics, Therapeutics > Gastroenterology, Therapeutics > Urology, Therapeutics > Transplant

Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)

Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...

Published: 7/17/2025 | Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton

Keywords(s):

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment

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