Search Results - david+shackelford

3 Results

Sort By:

The Use of Voltage Sensitive Mitochondrial Uncouplers as Selective Anti-Cancer Drugs (UCLA Case No. 2022-327)

UCLA researchers from the Department of Medicine have identified an anti-cancer drug that targets mitochondrial membrane potential to selectively kill tumor cells, showing efficacy for traditionally treatment-resistant lung cancers. BACKGROUND: Non-small cell lung cancer (NSCLC) is a devastating disease that will claim the lives of approximately 125,000...

Published: 2/17/2026 | Inventor(s): David Shackelford

Keywords(s):

Category(s): Therapeutics > Respiratory And Pulmonary, Therapeutics > Oncology

Improving Responses to mTOR Inhibitors (UCLA Case No. 2025-205)

Contact UCLA Technology Development Group to learn more.

Published: 9/18/2025 | Inventor(s): Milica Momcilovic, David Shackelford

Keywords(s):

Category(s): Therapeutics > Respiratory And Pulmonary, Therapeutics > Oncology

Positron Emission Tomography Guided Delivery of Mitochondrial Complex I Inhibitors (UCLA Case No. 2020-163)

UCLA researchers in the David Geffen School of Medicine Division of Pulmonary and Critical Care Medicine have developed a novel use of the positron emission tomography (PET) tracer [18F]FBnTP to guide the delivery of mitochondrial complex I inhibitors for the treatment of lung cancers.BACKGROUND: The mitochondria are essential regulators of cellular...

Published: 7/17/2025 | Inventor(s): David Shackelford, Seyed Saman Sadeghi Hosseini, Milica Momcilovic

Keywords(s): Diagnostic Markers & Platforms, Imaging, Medical Imaging, PET, Respiratory & Pulmonary

Category(s): Medical Devices > Medical Imaging > PET, Therapeutics > Oncology, Therapeutics > Respiratory And Pulmonary