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2015-612 PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS VIA RING OPENING REACTIONS
INTRO SENTENCE: UCLA researchers in the Department of Bioengineering have developed a simple approach to modify polypeptides and proteins.BACKGROUND: Functionalized polypeptides and proteins are useful as drug delivery vehicles, bioconjugates and novel ligands. However, synthesis of complex polypeptides with defined post-polymerization modifications...
Published: 7/19/2023
|
Inventor(s):
Timothy Deming
,
Eric Gharakhanian
Keywords(s):
Chemical Manufacturing & Industrial/Bulk Chemicals
,
Drug Delivery
,
Peptide Base
Category(s):
Chemical > Synthesis
,
Platforms > Drug Delivery
,
Platforms > Drug Delivery > Peptide Base
,
Chemical > Industrial & Bulk Chemicals
2016-579 PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES
Preparation Of Functional Homocysteine Residues In Polypeptides And PeptidesSUMMARYUCLA researchers in the Department of Bioengineering and Department of Chemistry & Biochemistry have developed a novel method for efficient, chemoselective transformation of methionines in peptides and polypeptides into stable, functional homocysteine derivatives....
Published: 7/19/2023
|
Inventor(s):
Timothy Deming
,
Eric Gharakhanian
Keywords(s):
Category(s):
Platforms > Drug Delivery
,
Platforms > Drug Delivery > Peptide Base