Search Results - peptide+base

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2015-612 PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS VIA RING OPENING REACTIONS

INTRO SENTENCE: UCLA researchers in the Department of Bioengineering have developed a simple approach to modify polypeptides and proteins.BACKGROUND: Functionalized polypeptides and proteins are useful as drug delivery vehicles, bioconjugates and novel ligands. However, synthesis of complex polypeptides with defined post-polymerization modifications...

Published: 7/19/2023 | Inventor(s): Timothy Deming, Eric Gharakhanian

Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Drug Delivery, Peptide Base

Category(s): Chemical > Synthesis, Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Chemical > Industrial & Bulk Chemicals

2007-468 BBP AS A COMPLEXED CARRIER FOR BONE GROWTH FACTORS

BBP as a Complexed Carrier for Bone Growth FactorsSUMMARYUCLA researchers have identified a BMP binding peptide that binds to bone growth factors to increase their residence time at the site of implantation for treatment of bone defects.BACKGROUNDBone morphogenetic proteins (BMPs) are a group of growth factors that are able to induce the formation of...

Published: 7/19/2023 | Inventor(s): Samuel Murray, Elsa Murray, Jeffrey Wang, Keyvan Behnam

Keywords(s): Drug Delivery, Musculoskeletal Disease, Peptide Base, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Therapeutics, Therapeutics > Musculoskeletal Disease

2018-157 Approach for Efficient Protein Incorporation into Recombinant Vaults

Approach For Efficient Protein Incorporation Into Recombinant VaultsSUMMARYUCLA researchers in the departments of Medicine, Microbiology, Immunology & Molecular Genetics, and Bioengineering have developed a novel method for loading protein payloads into vault nanoparticle carriers.BACKGROUNDVaults are naturally occurring nanoparticles that are widely...

Published: 7/19/2023 | Inventor(s): Otto Yang, Z. Hong Zhou, Jan Mrazek, Ke Ding

Keywords(s): Drug Delivery, Nanoparticles, Peptide Base

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nanoparticles, Platforms > Drug Delivery > Peptide Base

Chemoselective Side-Chain Modifications Of Methionine-Containing Elastin-Like Polypeptides

SummaryUCLA researchers in the Department of Bioengineering and Department of Chemistry & Biochemistry have developed a novel method for the introduction of various functional groups onto recombinant elastin-like polypeptides (ELPs), creating new compositions of ELPs that may be used for medical therapeutic or diagnostic applications.BackgroundRecombinant...

Published: 7/19/2023 | Inventor(s): Timothy Deming, Sebastien Le-Commandoux, Elizabeth Garanger

Keywords(s): Drug Delivery, Peptide Base

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base

2017-459 Noncrushable Pill Formulations

Noncrushable/Nonabusable Pill FormulationsSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have developed novel abuse-deterrent opioid formulations from elastomers that resist crushing at room temperature and upon heating or cooling. The formulation also contains a dual-enzyme responsive system whereby sequential digestion by...

Published: 7/19/2023 | Inventor(s): Heather Maynard, Samantha Paluck, Natalie Boehnke

Keywords(s): Drug Delivery, Peptide Base, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Therapeutics

2017-446 Dual-Enzyme Responsive Peptides

Dual-Enzyme Responsive PeptidesSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have developed a dual-enzyme responsive peptide system that requires sequential digestion by two separate enzymes for cleavage at the C-terminal position of lysine.BACKGROUNDDue to their high selectivity and specificity, enzyme responsive systems...

Published: 7/19/2023 | Inventor(s): Heather Maynard, Natalie Boehnke

Keywords(s): Drug Delivery, Peptide Base

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base

2009-463 BMP BINDING PROTEINS AND PROSTHETIC SURFACES

BMP Binding Proteins and Prosthetic SurfacesSUMMARYUCLA researchers have developed a method to attach and enhance the activity of bone growth factors to prostheses through BMP binding proteins to increase the integration of prostheses and bone.BACKGROUNDIncreasing the integration of prostheses (dental implants, prosthetic hip “sockets”,...

Published: 7/19/2023 | Inventor(s): Samuel Murray, Elsa Murray, Jeffrey Wang, Keyvan Behnam

Keywords(s): Drug Delivery, Musculoskeletal Disease, Peptide Base, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Therapeutics, Therapeutics > Musculoskeletal Disease

Use Of Non-Ionic Copolypeptide Hydrogels For Cell Suspension And Cell And Molecule Delivery

SummaryUCLA researchers in the Departments of Bioengineering, Chemistry and Biochemistry, and Neurobiology have developed novel copolypeptide hydrogel formulations for the delivery of cells and molecules to locations throughout the body, including the central nervous system.BackgroundCentral nervous system (CNS) disorders, commonly caused by trauma,...

Published: 7/19/2023 | Inventor(s): Timothy Deming, Michael Sofroniew, Shanshan Zhang

Keywords(s): Cns, Drug Delivery, Medical Devices and Materials, Peptide Base

Category(s): Medical Devices, Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Therapeutics > CNS and Neurology