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Physical Separation of Ultrashort Single-Stranded Cell-Free DNA in Biofluids Using Differential Filtration and Next-Generation Sequencing Pipeline to Detect Methylation Status of Ultrashort Single-Stranded Cell-Free DNA (UCLA 2023-077, 2023-082)
UCLA researchers in the Department of Dentistry have established novel extraction and bioinformatics pipeline of ultrashort single-stranded cell-free DNA for the use in liquid biopsy diagnostics. BACKGROUND: Liquid biopsy is a critical diagnostic tool for various human diseases. The rapid market growth of liquid biopsy is primarily driven by novel...
Published: 9/11/2025
|
Inventor(s):
David Wong
,
Jordan Cheng
Keywords(s):
Cancer
,
cell-free DNA
,
circulating DNA
,
Diagnostic Markers & Platforms
,
DNA methylation
,
liquid biopsy
,
next generation sequencing (NGS)
Category(s):
Software & Algorithms > Bioinformatics
,
Life Science Research Tools > Research Methods
,
Platforms > Diagnostic Platform Technologies
Analysis of Ultrashort Single-Stranded Cell-Free DNA in Patient Saliva for Disease Detection (UCLA Cases 2022-292, 2022-043)
UCLA researchers have developed a novel next-generation sequencing (NGS) pipeline designed specifically to detect ultrashort single-stranded cell-free DNA (uscfDNA), providing significant advancements in sensitivity, clinical utility, and genomic research applications. Background: Cell-free DNA (cfDNA) fragments circulate in body fluids and have become...
Published: 9/11/2025
|
Inventor(s):
David Wong
,
Jordan Cheng
Keywords(s):
Category(s):
Life Science Research Tools > Research Methods
,
Platforms > Diagnostic Platform Technologies
2015-671 Underground Shafts for Hydrogen Storage
SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...
Published: 7/17/2025
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Inventor(s):
Adrienne Lavine
,
Hossein Kavehpour
,
Dante Simonetti
,
Richard Wirz
,
Chen Chen
,
Gabriela Bran
,
Gopinath Warrier
,
Hamarz Aryafar
,
Jonathon Kennedy
,
Joshua Jordan
,
Keith Lovegrove
Keywords(s):
Energy & Water
Category(s):
Energy & Environment > Energy Generation > Solar
,
Energy & Environment > Energy Storage