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A Ventilated Artificial Human Lung Exposure System to Analyze and Test Human Exposures to Inhaled Substances (Case No. 2023-306)
Summary: UCLA researchers in the Department of Medicine and Environmental Health Sciences have developed a ventilated human lung system for laboratory testing of inhaled substances. Background: Measuring the toxicology of inhaled air, aerosols and other substances is challenging due to the complexity of human studies and limitations in existing...
Published: 3/27/2025
|
Inventor(s):
Michael Roth
,
Airi Harui
,
Yifang Zhu
,
Haoxuan Chen
Keywords(s):
aerosol
,
Angiogenesis Acute Lung Injury
,
bioaerosol
,
cardiopulmonary illness
,
Cellular Respiration
,
consumer goods and products
,
Lung
,
Lung Pulmonology
,
non-small cell lung cancer
,
Preclinical model development
,
Preclinical surgical innovation
,
pulmonary arterial pressure (PAP)
,
pulmonary failure
,
Pulmonary fibrosis
,
Respiratory & Pulmonary
,
respiratory failure
,
right atrial to pulmonary canula
,
Simulation & Modeling
,
simulation model
,
small cell lung cancer
Category(s):
Platforms
,
Platforms > Drug Delivery
,
Life Science Research Tools
,
Life Science Research Tools > Research Methods
,
Therapeutics
,
Therapeutics > Respiratory And Pulmonary
,
Mechanical
,
Mechanical > Sensors
Single-Chain Bispecific Chimeric Antigen Receptor Targeting BCMA and CS1 for the Treatment of Multiple Myeloma (UCLA Case No. 2018-680)
UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a single-chain bispecific chimeric antigen receptor targeting BCMA and CS1 for treating multiple myeloma. BACKGROUND: Multiple myeloma (MM) is a cancer of the plasma cells that accounts for over 30,000 new diagnoses each year, according to the American Cancer...
Published: 2/19/2025
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Inventor(s):
Yvonne Chen
,
Eugenia Zah
Keywords(s):
Hematology
,
Immunotherapy
,
Life Science Research Tools
,
Therapeutics & Vaccines
Category(s):
Life Science Research Tools
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Hematology
Methods to Improve Chimeric Antigen Receptor (CAR)-T Cell Efficacy Through Rational Sequence and Structural Modifications (UCLA Case No. 2020-497)
UCLA researchers in the Department of Microbiology, Immunology & Molecular Genetics have developed novel engineering methodologies for CAR molecules that overcome the tonic signaling process that leads to T cell exhaustion and poor therapy efficacy. Background: Immunotherapy has become a highly effective method to combat cancer that enhances a...
Published: 2/14/2025
|
Inventor(s):
Yvonne Chen
Keywords(s):
Cancer Immunotherapy
Category(s):
Therapeutics > Oncology > Oncology Immunotherapy
Liquid Metal Printing Technique via Optical Maskless Lithography (Case No. 2024-031)
Summary: Researchers in the UCLA Department of Materials Science and Engineering have developed a facile, rapid method to print soft, wearable electronics. Background: Soft electrical circuits have garnered significant interest in a broad range of emerging technologies, including wearable electronics, brain-machine interfaces, and soft robotics....
Published: 3/6/2025
|
Inventor(s):
Ximin He
,
Dong Wu
Keywords(s):
Coating
,
Coatings, Adhesives, & Inks
,
Electronics & Semiconductors
,
Fabrication Technologies
,
gallium-based liquid metals
,
General Device Coatings
,
Liquid metal particles
,
liquid metals
,
Metals
,
Microelectronics Semiconductor Device Fabrication
,
Polymer
,
Polymers
,
scalable fabrication
,
Semiconductor Device Fabrication
,
soft electrical circuits
,
soft electronics
,
wearable electronics
,
wearable sensors
Category(s):
Chemical
,
Chemical > Polymers
,
Chemical > Coatings, Adhesives & Inks
,
Electrical
,
Electrical > Electronics & Semiconductors
,
Electrical > Sensors
,
Electrical > Instrumentation
,
Electrical > Flexible Electronics
,
Materials
,
Materials > Fabrication Technologies
,
Materials > Composite Materials
,
Materials > Metals
Discovering Permanent Fluidic Magnets for Liquid Bioelectronics (Case No. 2024-083)
Summary: UCLA researchers from the Department of Bioengineering have developed a permanent fluidic magnet that maintains stable colloids for application in a variety of fields, including physiological monitoring and bioelectronics. Background: Colloid suspensions are comprised of dispersed small solid particles in fluids. The stability of a colloid...
Published: 3/20/2025
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Inventor(s):
Jun Chen
Keywords(s):
Category(s):
Materials
,
Materials > Functional Materials
,
Materials > Membranes
,
Electrical
,
Electrical > Mems
,
Materials > Nanotechnology
,
Platforms
,
Platforms > Drug Delivery
Engineered T Cells Capable of Simultaneous Tumor Targeting and Alteration of Tumor Microenvironment Through Vasculature Normalization (UCLA Case No. 2023-264)
UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have built a series of chimeric antigen receptor (CAR)-T cells that target different antigens and secrete different anti-angiogenic proteins. Additionally, researchers also constructed bispecific CARs that respond to tumor antigen and pro-angiogenic molecules. BACKGROUND:...
Published: 2/14/2025
|
Inventor(s):
Yvonne Chen
Keywords(s):
Cancer
,
Cancer Immunotherapy
,
CAR-T cell therapy
,
immunosuppression
,
Immunosuppressive Drug
,
Immunotherapy
,
solid tumors
,
Tumor microenvironment
,
tumor vasculature
,
VEGF
Category(s):
Therapeutics > Oncology
Object-Detecting Deep Learning for Multi-Event Electrochemical Data (Case No. 2024-088)
Summary: UCLA researchers in the Department of Chemistry and Biochemistry developed a custom-designed deep learning architecture for object detection and mechanisms classification to streamline the experimental design of cyclic voltammograms. Background: Cyclic voltammetry, a widely used electrochemical test, serves as a crucial tool in understanding...
Published: 2/14/2025
|
Inventor(s):
Chong Liu
,
Quanquan Gu
,
Benjamin Hoar
,
Weitong Zhang
,
Yuanzhou Chen
Keywords(s):
2D ultrasound imaging
,
Artifical Intelligence (Machine Learning, Data Mining)
,
artificial electromagnetic materials
,
bioelectronics
,
Biomaterial
,
electrochemical sensors
,
Electronics & Semiconductors
,
Lithium Battery
,
Lithium-Ion Battery
,
Machine Learning
,
Materials
,
Medical Devices and Materials
,
Medical diagnostics
,
Pharmaceutical Drug
,
Pharmaceutical testing
,
Rechargeable Battery
,
zzenergy storage
Category(s):
Electrical > Electronics & Semiconductors
,
Energy & Environment > Energy Efficiency
,
Energy & Environment > Energy Storage
,
Energy & Environment > Water Monitoring & Treatment
,
Software & Algorithms > Image Processing
,
Software & Algorithms > Artificial Intelligence & Machine Learning
,
Electrical > Signal Processing
Speaking Without Vocal Folds Using Machine-Learning-Assisted Wearable Sensing-Actuation Systems (Case No. 2024-087)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel, machine learning-assisted wearable loudspeaker to capture and translate muscle movement into audible speech. Background: Dysphonia, or the impairment of voice production, is commonly caused by disorders of the vocal folds or postoperative recovery of laryngeal...
Published: 2/14/2025
|
Inventor(s):
Jun Chen
Keywords(s):
Category(s):
Electrical
,
Electrical > Sensors
,
Medical Devices
,
Medical Devices > Monitoring And Recording Systems
A Wearable On-Eyelid Sensor Network for Vestibular-Ocular Reflex Assessment (Case No. 2023-166)
Summary: UCLA researchers in the Department of Bioengineering have developed an ultra-thin, self-powered, waterproof, biocompatible, and sensitive on-eyelid sensor network for wireless eye movement detection, enhancing vestibular diagnostics. Background: The human balance system relies on the interaction of the vestibular system with the visual and...
Published: 2/14/2025
|
Inventor(s):
Jun Chen
,
Jing Xu
Keywords(s):
diseases of the eye
,
eye motion
,
eye movement disorders
,
eye tracking
,
gaze fixation
,
magnetoelastic effect
,
magnetoelastic sensor
,
on-eyelid sensor
,
peripheral vestibular disorders
,
vestibular pathology assessment
,
Vestibular-Ocular Reflex (VOR)
Category(s):
Medical Devices
,
Medical Devices > Monitoring And Recording Systems
,
Therapeutics
,
Electrical
,
Electrical > Signal Processing
,
Electrical > Sensors
Field-Effect Transistor Biosensors Integrated With Porous Media (Case No. 2023-093)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering in collaboration with the University of Chicago have developed a new diagnostic biosensor by combining field-effect transistors with porous media. Background: Point-of-care (POC) and self-testing tools rely on the real-time monitoring of biomarkers in bodily fluids....
Published: 2/14/2025
|
Inventor(s):
Aydogan Ozcan
,
Hyouarm Joung
,
Hyun-June Jang
,
Junhong Chen
Keywords(s):
Biomarker
,
biomarkers
,
Biomaterial
,
Biosensor
,
Computer-Aided Diagnosis
,
Diagnostic Markers & Platforms
,
Diagnostic Platform Technologies (E.G. Microfluidics)
,
Diagnostic Test
,
Electrical
,
Electrical Engineering
,
electrically-mediated sensing
,
electrochemical sensors
,
enzyme functionalization
,
field-effect transistors (FETs)
,
Medical diagnostics
,
multiplexed analysis
,
Point Of Care
,
point-of-care
,
porous media
,
sample matrix effects
,
transistors
Category(s):
Electrical
,
Electrical > Sensors
,
Medical Devices
,
Medical Devices > Monitoring And Recording Systems
,
Diagnostic Markers
,
Diagnostic Markers > Targets And Assays
,
Platforms
,
Platforms > Diagnostic Platform Technologies
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