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Methods to Improve Chimeric Antigen Receptor (CAR)-T Cell Efficacy Through Rational Sequence and Structural Modifications (UCLA Case No. 2020-497)

UCLA researchers in the Department of Microbiology, Immunology & Molecular Genetics have developed novel engineering methodologies for CAR molecules that overcome the tonic signaling process that leads to T cell exhaustion and poor therapy efficacy. Background: Immunotherapy has become a highly effective method to combat cancer that enhances a...

Published: 9/30/2024 | Inventor(s): Yvonne Chen

Keywords(s): Cancer Immunotherapy

Category(s): Therapeutics > Oncology > Oncology Immunotherapy

Liquid Metal Printing Technique via Optical Maskless Lithography (Case No. 2024-031)

Summary: Researchers in the UCLA Department of Materials Science and Engineering have developed a facile, rapid method to print soft, wearable electronics. Background: Soft electrical circuits have garnered significant interest in a broad range of emerging technologies, including wearable electronics, brain-machine interfaces, and soft robotics....

Published: 10/15/2024 | Inventor(s): Ximin He, Dong Wu

Keywords(s): Coating, Coatings, Adhesives, & Inks, Electronics & Semiconductors, Fabrication Technologies, gallium-based liquid metals, General Device Coatings, Liquid metal particles, liquid metals, Metals, Microelectronics Semiconductor Device Fabrication, Polymer, Polymers, scalable fabrication, Semiconductor Device Fabrication, soft electrical circuits, soft electronics, wearable electronics, wearable sensors

Category(s): Chemical, Chemical > Polymers, Chemical > Coatings, Adhesives & Inks, Electrical, Electrical > Electronics & Semiconductors, Electrical > Sensors, Electrical > Instrumentation, Electrical > Flexible Electronics, Materials, Materials > Fabrication Technologies, Materials > Composite Materials, Materials > Metals

Discovering Permanent Fluidic Magnets for Liquid Bioelectronics (Case No. 2024-083)

Summary: UCLA researchers from the Department of Bioengineering have developed a permanent fluidic magnet that maintains stable colloids for application in a variety of fields, including physiological monitoring and bioelectronics. Background: Colloid suspensions are comprised of dispersed small solid particles in fluids. The stability of a colloid...

Published: 10/23/2024 | Inventor(s): Jun Chen

Keywords(s):

Category(s): Materials, Materials > Functional Materials, Materials > Membranes, Electrical, Electrical > Mems, Materials > Nanotechnology, Platforms, Platforms > Drug Delivery

Engineered T Cells Capable of Simultaneous Tumor Targeting and Alteration of Tumor Microenvironment Through Vasculature Normalization (UCLA Case No. 2023-264)

UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have built a series of chimeric antigen receptor (CAR)-T cells that target different antigens and secrete different anti-angiogenic proteins. Additionally, researchers also constructed bispecific CARs that respond to tumor antigen and pro-angiogenic molecules. BACKGROUND:...

Published: 6/27/2024 | Inventor(s): Yvonne Chen

Keywords(s): Cancer, Cancer Immunotherapy, CAR-T cell therapy, immunosuppression, Immunosuppressive Drug, Immunotherapy, solid tumors, Tumor microenvironment, tumor vasculature, VEGF

Category(s): Therapeutics > Oncology

Object-Detecting Deep Learning for Multi-Event Electrochemical Data (Case No. 2024-088)

Summary: UCLA researchers in the Department of Chemistry and Biochemistry developed a custom-designed deep learning architecture for object detection and mechanisms classification to streamline the experimental design of cyclic voltammograms. Background: Cyclic voltammetry, a widely used electrochemical test, serves as a crucial tool in understanding...

Published: 8/23/2024 | Inventor(s): Chong Liu, Quanquan Gu, Benjamin Hoar, Weitong Zhang, Yuanzhou Chen

Keywords(s): 2D ultrasound imaging, Artifical Intelligence (Machine Learning, Data Mining), artificial electromagnetic materials, bioelectronics, Biomaterial, electrochemical sensors, Electronics & Semiconductors, Lithium Battery, Lithium-Ion Battery, Machine Learning, Materials, Medical Devices and Materials, Medical diagnostics, Pharmaceutical Drug, Pharmaceutical testing, Rechargeable Battery, zzenergy storage

Category(s): Electrical > Electronics & Semiconductors, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Storage, Energy & Environment > Water Monitoring & Treatment, Software & Algorithms > Image Processing, Software & Algorithms > Artificial Intelligence & Machine Learning, Electrical > Signal Processing

Speaking Without Vocal Folds Using Machine-Learning-Assisted Wearable Sensing-Actuation Systems (Case No. 2024-087)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel, machine learning-assisted wearable loudspeaker to capture and translate muscle movement into audible speech. Background: Dysphonia, or the impairment of voice production, is commonly caused by disorders of the vocal folds or postoperative recovery of laryngeal...

Published: 10/4/2024 | Inventor(s): Jun Chen

Keywords(s):

Category(s): Electrical, Electrical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems

A Wearable On-Eyelid Sensor Network for Vestibular-Ocular Reflex Assessment (Case No. 2023-166)

Summary: UCLA researchers in the Department of Bioengineering have developed an ultra-thin, self-powered, waterproof, biocompatible, and sensitive on-eyelid sensor network for wireless eye movement detection, enhancing vestibular diagnostics. Background: The human balance system relies on the interaction of the vestibular system with the visual and...

Published: 4/19/2024 | Inventor(s): Jun Chen, Jing Xu

Keywords(s): diseases of the eye, eye motion, eye movement disorders, eye tracking, gaze fixation, magnetoelastic effect, magnetoelastic sensor, on-eyelid sensor, peripheral vestibular disorders, vestibular pathology assessment, Vestibular-Ocular Reflex (VOR)

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics, Electrical, Electrical > Signal Processing, Electrical > Sensors

Field-Effect Transistor Biosensors Integrated With Porous Media (Case No. 2023-093)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering in collaboration with the University of Chicago have developed a new diagnostic biosensor by combining field-effect transistors with porous media. Background: Point-of-care (POC) and self-testing tools rely on the real-time monitoring of biomarkers in bodily fluids....

Published: 4/1/2024 | Inventor(s): Aydogan Ozcan, Hyou-Arm Joung, Hyun-June Jang, Junhong Chen

Keywords(s): Biomarker, biomarkers, Biomaterial, Biosensor, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Electrical, Electrical Engineering, electrically-mediated sensing, electrochemical sensors, enzyme functionalization, Medical diagnostics, multiplexed analysis, Point Of Care, point-of-care, porous media, sample matrix effects, transistors

Category(s): Electrical, Electrical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms, Platforms > Diagnostic Platform Technologies

Novel Anti-mesothelin CAR for Use in Engineered Cell Therapies (UCLA Case No. 2023-281)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a nanobody-based CAR T cell platform with increased stability and cross-immunogenicity between human and mouse antigens. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered T cells to target and clear cancer cells....

Published: 6/28/2024 | Inventor(s): Yvonne Chen

Keywords(s): Cancer, CAR-T cell platform, CAR-T cell therapy, cell engineering, Immunotherapy, Mesothelin, nanobody, Nanoparticle

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Synaptic Circuits Made From Transistors and Memory Capacitors (UCLA Case No. 2023-092)

Summary: UCLA researchers from the Department of Mechanical and Aerospace Engineering have developed a novel circuit architecture that emulates neural synapses for concurrent parallel computing. Background: Almost all modern computer chips consist of computing and learning processes that are implemented sequentially. To improve computing power,...

Published: 11/15/2024 | Inventor(s): Yong Chen, Zixuan Rong

Keywords(s): Application-Specific Integrated Circuit, Artifical Intelligence (Machine Learning, Data Mining), artificial electromagnetic materials, Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, Artificial Neural Network Artificial Neuron, artificial-intelligent materials, autonomous control, computational efficiency, edge computing, Electronics & Semiconductors, Energy Efficiency, energy management, Integrated Circuit, Medical artificial intelligence (AI), Neuromorphic circuits, parallel processing, parallel signal processing, processor design, Semiconductor, semiconductor chip foundries, Semiconductor Device, Semiconductors, synaptic resistor (synstor)

Category(s): Electrical, Electrical > Electronics & Semiconductors, Electrical > Signal Processing, Materials, Materials > Semiconducting Materials, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning

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