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Compounds that Disaggregate Alzheimer's Disease-Associated Fibrils of Tau Protein (UCLA Case No. 2022-145, 2025-329)

UCLA researchers in the Department of Biological Chemistry, Chemistry and Biochemistry developed a new tau-inhibiting seven residue peptide and conjugated it to magnetic nanoparticles for the treatment of Alzheimer’s disease. These compounds disaggregate pathogenic tau amyloid fibrils at atomic resolution, restore normal neuronal function, and...

Published: 11/19/2025 | Inventor(s): David Eisenberg, Ke Hou

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Category(s): Therapeutics > CNS and Neurology