Search Results - david+eisenberg

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2019-772: A Single Chain Antibody That Binds Tau Oligomers and Inhibits Seeding by Pathological Extracts From Alzheimer’s Disease

SUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have developed a method for efficiently producing tau oligomers and a single-chain antibody against oligomeric tau protein with potential for theranostic utility in the treatment of Alzheimer’s and other tauopathies.BACKGROUND:Alzheimer’s disease (AD) is the most prevalent...

Published: 9/5/2023 | Inventor(s): David Eisenberg

Keywords(s): Amyloid, Antibodies, Central Nervous System, Genetic Disease, Life Science Research Tools, Neurodegeneration Alzheimer's Disease Predictive Testing, Tau Protein

Category(s): Life Science Research Tools > Antibodies, Therapeutics > CNS and Neurology

2019-701 PEPTIDE-BASED INHIBITORS THAT BLOCK AGGREGATION, SEEDING AND CROSS-SEEDING OF AMYLOID BETA AND TAU

UCLA researchers in the Department of Chemistry and Biochemistry have developed novel therapeutics for Alzhiemer’s Disease and other tauoapathies. BACKGROUND:Alzhiemer’s Disease (AD) is a severe neurodegenerative disease characterized by deterioration of the brain cells and loss of multiple cognitive functions. Although AD is the most...

Published: 7/19/2023 | Inventor(s): David Eisenberg, Paul Seidler

Keywords(s): Cns, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology

2004-087 Antimicrobial Peptide for the Treatment of Skin Diseases

Antimicrobial Peptide for the Treatment of Skin DiseasesSUMMARYGranulysin peptides are small antimicrobial agents with potent activity against bacteria and inflammation. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient suffering from a microbial infection.

Published: 7/19/2023 | Inventor(s): David Eisenberg, Robert Modlin, Jenny Kim, Daniel Anderson, Richard Gallo

Keywords(s): Dermatology, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Dermatology

2018-348 NOVEL TAU AGGREGATION INHIBITOR PEPTIDE

Novel Tau Aggregation Inhibitor PeptideSUMMARYUCLA researchers from the Department of Chemistry and Biochemistry have developed a novel approach to inhibit the aggregation of tau proteins in the brain, which is linked to over 20 dementias including Alzheimer’s Disease and Chronic Traumatic Encephalopathy.BACKGROUNDAggregation of tau protein is...

Published: 7/19/2023 | Inventor(s): David Eisenberg, Paul Seidler

Keywords(s): Cns, Gene Editing Systems, Gene Therapy, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing

2016-694 INHIBITION OF THE AGGREGATION OF TRANSTHYRETIN BY SPECIFIC BINDING OF PEPTIDES TO AGGREGATION-DRIVING SEGMENTS

Inhibition of the Aggregation of Transthyretin by Specific Binding of Peptides to Aggregation-Driving SegmentsSUMMARYUCLA researchers from the Department of Chemistry and Biochemistry have developed a novel process to inhibit amyloid aggregation of Transthyretin, which is associated with three debilitating disorders including senile systemic amyloidosis...

Published: 9/5/2023 | Inventor(s): David Eisenberg, Lorena Saelices Gomez

Keywords(s): Cardiovascular, Cns, Genetic Disease, Hematology, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Hematology, Therapeutics > CNS and Neurology