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Targeting Metabolic and Molecular Drivers to Stop Treatment- and Immune-Resistant Pancreatic Ductal Adenocarcinoma (UCLA Case No. 2025-9AD)

UCLA researchers in the Department of Medicine–Hematology/Oncology have developed next-generation metformin analogs that show improved antitumor efficacy and tumor microenvironment remodeling in pancreatic cancer. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer-related death in the U.S. with a 5-year survival...

Published: 5/28/2026 | Inventor(s): Richard Pietras, Michael Jung, Timothy Donahue, Diana Marquez-Garban

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Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology, Therapeutics > Inflammation And Inflammatory Diseases