Search Results - richard+pietras

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2012-601 Development of a New Approach to Kill Human Non-Small Cell Lung Cancer Stem Cells

Novel Small Molecules that Target Cancer Stem Cells for the Treatment of CancerBACKGROUNDLung cancer is the leading cause of cancer related death in the United States. In 2012, it is estimated that approximately 230,000 patients will be newly diagnosed, and since more than 160,000 individuals will succumb to this disease, there exists an urgent need...

Published: 7/19/2023 | Inventor(s): Michael Jung, Richard Pietras, Diana Marquez Garban, Gang Deng

Keywords(s): Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology > Oncology (Small Molecules)

Combination Therapy Approach Using Novel Biguanides For Cancer Treatment

SummaryResearchers in the UCLA Departments of Molecular and Medical Pharmacology, Chemistry and Biochemistry, Surgery, and Medicine have developed novel metformin analogues which, when combined with immune checkpoint inhibitors, enhance the therapeutic benefit of these inhibitors in treating triple-negative breast cancer and other malignancies.BackgroundImmune...

Published: 7/19/2023 | Inventor(s): Michael Jung, Jennifer Murphy, Richard Pietras, Begonya Comin-Anduix, Diana Marquez Garban

Keywords(s): Drug Delivery, Genetic Disease, Immunotherapy, Life Science Research Tools, Medical Devices and Materials, Oncology, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Medical Devices, Platforms > Drug Delivery, Therapeutics, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Metformin Derivatives for Treatment of Triple-Negative Breast Cancer and Other Malignancies

Case 2012-733BACKGROUNDBreast cancer is the most common type of cancer that occurs in women in the US and ranks as the second leading cause of cancer death after lung cancer. Of the 230,480 invasive breast cancer cases diagnosed in the US in 2011, approximately 15-20% were "triple negative breast cancer" (TNBC), a subtype of breast cancer...

Published: 7/19/2023 | Inventor(s): Michael Jung, Richard Pietras, Diana Marquez Garban, Gang Deng

Keywords(s):

Category(s): Therapeutics, Therapeutics > Oncology > Oncology (Small Molecules)

Second-Generation Estrogen Receptor Down-Regulators for Medical Therapy

Case 2015-166UCLA researchers in the School of Medicine have developed a series of novel estrogen receptor antagonists for breast cancer therapy.BACKGROUNDBreast cancer is the most common malignancy in women in North America. Each year, more than 210,000 new cases of breast cancer are diagnosed in the US. About 70% of breast cancers depend on estrogen...

Published: 7/19/2023 | Inventor(s): Richard Pietras, Michael Jung

Keywords(s): Endocrinology, Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology, Therapeutics > Oncology > Oncology (Small Molecules)