Search Results - richard+pietras

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Targeting Metabolic and Molecular Drivers to Stop Treatment- and Immune-Resistant Pancreatic Ductal Adenocarcinoma (UCLA Case No. 2025-9AD)

UCLA researchers in the Department of Medicine–Hematology/Oncology have developed next-generation metformin analogs that show improved antitumor efficacy and tumor microenvironment remodeling in pancreatic cancer. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer-related death in the U.S. with a 5-year survival...

Published: 5/28/2026 | Inventor(s): Richard Pietras, Michael Jung, Timothy Donahue, Diana Marquez-Garban

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Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology, Therapeutics > Inflammation And Inflammatory Diseases

Metformin Derivatives for Treatment of Triple-Negative Breast Cancer and Other Malignancies

Case 2012-733BACKGROUNDBreast cancer is the most common type of cancer that occurs in women in the US and ranks as the second leading cause of cancer death after lung cancer. Of the 230,480 invasive breast cancer cases diagnosed in the US in 2011, approximately 15-20% were "triple negative breast cancer" (TNBC), a subtype of breast cancer...

Published: 7/17/2025 | Inventor(s): Michael Jung, Richard Pietras, Diana Marquez-Garban, Gang Deng

Keywords(s):

Category(s): Therapeutics, Therapeutics > Oncology > Oncology (Small Molecules)

Second-Generation Estrogen Receptor Down-Regulators for Medical Therapy

Case 2015-166UCLA researchers in the School of Medicine have developed a series of novel estrogen receptor antagonists for breast cancer therapy.BACKGROUNDBreast cancer is the most common malignancy in women in North America. Each year, more than 210,000 new cases of breast cancer are diagnosed in the US. About 70% of breast cancers depend on estrogen...

Published: 7/17/2025 | Inventor(s): Richard Pietras, Michael Jung

Keywords(s): Endocrinology, Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology, Therapeutics > Oncology > Oncology (Small Molecules)