Search Results - timothy+o%27sullivan

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Oleate-Mediated Enhancement of Human Natural Killer Cell Function (UCLA Case No. 2024-180)

UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have discovered a novel approach to boost natural killer cell function through fatty acid supplementation. BACKGROUND: Natural killer (NK) cells are part of the body’s defense system that hunts down and kills cells that are infected by viruses or have become...

Published: 11/15/2024 | Inventor(s): Timothy O'Sullivan

Keywords(s): fatty acids, immune defense, immune disorders, Immunology, natural killer cells, nk cells

Category(s): Therapeutics > Immunology And Immunotherapy

2022-178: CRISPR-MEDIATED DELETION OF FLI1 IN NK CELLS

SUMMARY: UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel method to increase the immune response of natural killer cells by ablating the transcriptional regulator Fli1 via CRISPR. BACKGROUND: Natural killer (NK) cells are innate immune cells that combat viral infections and serve as the...

Published: 9/5/2023 | Inventor(s): Timothy O'Sullivan

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing, Therapeutics > Oncology > Oncology Immunotherapy

2021-056 CRISPR RIBONUCLEOPROTEIN COMPLEX GENOME EDITING OF HUMAN INNATE IMMUNE CELLS

Researchers in the Department of Microbiology, Immunology, and Molecular Genetics at UCLA have developed an optimized strategy for non-viral CRISPR-Cas9 ribonucleoprotein gene editing of primary innate immune cells. BACKGROUND:CRISPR (clustered, regularly interspaced, short palindromic repeats) genome engineering has become a powerful tool to investigate...

Published: 9/7/2023 | Inventor(s): Timothy O'Sullivan, Luke Riggan, Andrew Hildreth

Keywords(s): CRISPR, Gene Editing Systems

Category(s): Therapeutics > Gene Therapy And Editing