Search Results - immunology

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Oleate-Mediated Enhancement of Human Natural Killer Cell Function (UCLA Case No. 2024-180)

UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have discovered a novel approach to boost natural killer cell function through fatty acid supplementation. BACKGROUND: Natural killer (NK) cells are part of the body’s defense system that hunts down and kills cells that are infected by viruses or have become...

Published: 11/15/2024 | Inventor(s): Timothy O'Sullivan

Keywords(s): fatty acids, immune defense, immune disorders, Immunology, natural killer cells, nk cells

Category(s): Therapeutics > Immunology And Immunotherapy

2022-174 Diffractive All-Optical Computing for Quantitative Phase Imaging

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an all-optical quantitative phase imaging (QPI) method that could replace traditionally burdensome and power-inefficient computational image processing networks and improve current limitations in biological imaging. Background: The application of...

Published: 11/15/2024 | Inventor(s): Aydogan Ozcan, Deniz Mengu

Keywords(s): Diffraction Tomography, Digital Holography, Digital immunohistology, Electron Holography, Fluorescence Microscope, Histology, Holography, Immunohistochemistry, Immunology, Lighting and Illumination, on-chip microscopy, Optics, Photonics, quantitative phase imaging (QPI)

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Microscopy And Imaging, Electrical, Electrical > Sensors, Electrical > Signal Processing, Electrical > Imaging, Medical Devices > Medical Imaging, Optics & Photonics, Optics & Photonics > Microscopy, Optics & Photonics > Holography

2022-084 HUMAN LEUKOCYTE ANTIGEN HAPLOTYPE ANALYSIS TOOLKIT (HLA-HAT)

SUMMARY: UCLA researchers in the department of Medicine, Hematology and Oncology have developed software which facilitates the clinically relevant investigation of genetic antigen heterogeneity within human leukocytes BACKGROUND: Human leukocyte antigen system is a critical component of the immune system. A major part of this is a series of genes...

Published: 9/19/2024 | Inventor(s): Katie Campbell

Keywords(s): Algorithm, Allele, Autoimmune Disease, Bioinformatics, Biotechnology, CD3 (Immunology) Human Leukocyte Antigen, Functional Genomics, Genetic Algorithm, Genetic Testing, Immunology, Inflammation, Instrumentation & Analysis, Sequencing, Software, Software & Algorithms

Category(s): Life Science Research Tools, Software & Algorithms, Software & Algorithms > Bioinformatics

2020-421 EXTRACELLULAR VESICLES DERIVED FROM INDUCED PLURIPOTENT STEM CELLS FOR IMMUNOMODULATION

UCLA researchers in the Department of Bioengineering have developed a method to boost extracellular vesicles' (EVs) production and potency, potentially allowing large-scale clinical-grade EV manufacture for immunomodulatory therapeutics. BACKGROUNDExtracellular vesicles (EVs) are one of the most important mediators of cell-to-cell communication. EVs...

Published: 7/19/2023 | Inventor(s): Jana Zarubova, Mohammad Hasani-Sadrabadi, Song Li

Keywords(s): Immunology, Therapeutics & Vaccines, Transplant Rejection

Category(s): Life Science Research Tools > Research Methods, Therapeutics > Agtech And Animal Health, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2019-726 AUGMENTATING T-CELL ACTIVATION BY OSCILLATORY FORCES AND ENGINEERED ANTIGEN-PRESENTING CELLS

UCLA researchers in the Department of Pediatrics have developed a suite of novel spherical aAPCs of varying sizes and densities, that can be coupled with an oscillatory stimulus to promote efficient T cell activation: offering the possibility to aptly engineer T cells for a variety of clinical and experimental needs. BACKGROUND:T cells circulate throughout...

Published: 9/5/2023 | Inventor(s): Manish Butte, Fatemeh Sadat Majedi

Keywords(s): Immunology, Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy

Category(s): Life Science Research Tools > Antibodies, Life Science Research Tools > Research Methods, Diagnostic Markers > Immunology, Therapeutics > Oncology > Oncology Immunotherapy

2019-880 ZIKA VIRUS-BASED ONCOLYTIC THERAPY FOR BRAIN CANCER

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a novel zika virus-based oncolytic therapy to treat brain cancer.BACKGROUND: Glioma is a type of brain tumor that accounts for 80% of all primary malignant brain tumors. Standard therapy for high-grade glioma requires a combination of surgical resection, radiation...

Published: 9/12/2023 | Inventor(s): Vaithilingaraja Arumugaswami, David Nathanson

Keywords(s): Cns, Drug Delivery, Gene Editing Systems, Gene Therapy, Immunology, Immunotherapy, Oncology, Oncology Immunotherapy, Plasmids / Vectors, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Diagnostic Markers > Immunology, Therapeutics > CNS and Neurology, Therapeutics > Vaccines, Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing, Therapeutics > Oncology > Oncology Immunotherapy

Computational Cytometer Based on Magnetically-Modulated Coherent Imaging and Deep Learning

UC Case No. 2019-950 SUMMARY: UCLA researchers in the Department of Electrical & Computer Engineering have designed and built a computational cytometer capable of detecting rare cells at low concentration in whole blood samples. This technique and instrumentation can be used for cancer metastasis detection, immune response characterization and...

Published: 2/16/2024 | Inventor(s): Aydogan Ozcan, Aniruddha Ray, Yibo Zhang, Dino Di Carlo

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Immunology, Life Science Research Tools, Oncology, Software

Category(s): Life Science Research Tools > Lab Equipment, Diagnostic Markers > Immunology, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology > Oncology (Small Molecules), Software & Algorithms > Programs

Identification of a Factor that Promotes Human HSC Self-Renewal

Case 2016-990The Mikkola group at UCLA has discovered a novel regulator of hematopoietic stem cell self-renewal. The overexpression of this regulator increases the yield of ex vivo stem cell expansion and could thereby improve the efficiency of stem cell therapies. BACKGROUNDBlood cells are responsible for the maintenance and immune protection of nearly...

Published: 7/19/2023 | Inventor(s): Hanna Mikkola, Vincenzo Calvanese, Andrew Nguyen

Keywords(s): Diagnostic Markers & Platforms, Gene Editing Systems, Gene Therapy, Immunology, Immunotherapy, Life Science Research Tools, Oncology, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Immunology, Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing

2016-882 HIGH THROUGHPUT DIGITAL CELL QUANTIFICATION OF IMMUNE CELL SUBSETS VIA EPIGENETIC MARKERS

High Throughput Digital Cell Quantification Of Immune Cell Subsets Via Epigenetic MarkersSUMMARYUCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel high-throughput method for the quantification of immune cell subtype.BACKGROUNDQuantification of leukocytes (white blood cells) among peripheral blood...

Published: 7/19/2023 | Inventor(s): Dennis Montoya, Matteo Pellegrini

Keywords(s): Autoimmune, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Immunology

Category(s): Diagnostic Markers, Diagnostic Markers > Immunology, Platforms > Diagnostic Platform Technologies, Therapeutics > Autoimmune

GM-CSF and IL-4 Therapy for In Situ Expansion of Dendritic Cells and Enhancement of Vaccine-Based Immunity

Case 1998-556INNOVATIONDendritic cells (DC) are a group of professional antigen presenting cells (APC) that provide a central stimulus for the generation of cell-mediated responses against foreign antigens. Dendritic cells are ubiquitously distributed throughout the body, where they pick up antigens, process them, and migrate to T-cell enriched areas...

Published: 7/19/2023 | Inventor(s): Michael Roth, Sylvia Kiertscher, Robert Figlin, Barbara Gitlitz

Keywords(s): Immunology, Oncology Immunotherapy, Therapeutics & Vaccines

Category(s): Diagnostic Markers > Immunology, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy

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