Search Results - carla+koehler

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2018-022 SMALL MOLECULE MODULATORS THAT MEDIATE PINK1 AND PARKIN TRAFFICKING IN MITOCHONDRIA

UCLA researchers have developed two novel small molecule probes, MB-10 and DECA, that attenuate PINK1 and Parkin trafficking in mitochondrial in human cells that provide a new approach to elucidate the mechanisms of mitophagy.BACKGROUND:Mitophagy is an important pathway that selectively degrades dysfunctional mitochondria to keep the cell healthy. Neurodegenerative...

Published: 7/19/2023 | Inventor(s): Carla Koehler

Keywords(s): Life Science Research Tools, Other Reagents

Category(s): Life Science Research Tools > Other Reagents

2009-533 A MOLECULAR PATHWAY FOR IMPORTING RNA INTO MITOCHONDRIA

Case No. 2009-533SUMMARYResearchers at UCLA’s Jonsson Comprehensive Cancer Center, the Department of Chemistry and Biochemistry, and the Department of Pathology and Laboratory Medicine have uncovered a role for an essential cell protein, polynucleotide phosphorylase (PNPASE) in shuttling RNA into the mitochondria, the energy-producing “power...

Published: 7/19/2023 | Inventor(s): Michael Teitell, Carla Koehler, Geng Wang

Keywords(s): Genetic Disease, Oncology, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology

2009-221 Small Molecule Modulators of Mitochondrial Protein Import (MitoBloCK1)

Small Molecule Modulators Of Mitochondrial Protein ImportSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have discovered a set of small molecules that modulate the protein translocation across the mitochondrial membranes, which in turn controls the assembly and function of the mitochondria.BACKGROUNDMitochondria are rod-shaped...

Published: 7/19/2023 | Inventor(s): Carla Koehler, Samuel Hasson

Keywords(s): Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology > Oncology (Small Molecules)